ID   AB17C_DANRE             Reviewed;         294 AA.
AC   Q7ZVZ7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Alpha/beta hydrolase domain-containing protein 17C {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 17C {ECO:0000250|UniProtKB:Q6PCB6};
DE            EC=3.1.2.22 {ECO:0000250|UniProtKB:Q8VCV1};
GN   Name=abhd17c {ECO:0000250|UniProtKB:Q6PCB6}; ORFNames=zgc:55468;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in
CC       proteins. Has depalmitoylating activity towards nras.
CC       {ECO:0000250|UniProtKB:Q6PCB6}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC         hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC         Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:74151; EC=3.1.2.22;
CC         Evidence={ECO:0000250|UniProtKB:Q6PCB6};
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane
CC       {ECO:0000250|UniProtKB:B5DFK7}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:B5DFK7}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:B5DFK7}. Cell projection, dendritic spine
CC       {ECO:0000250|UniProtKB:B5DFK7}. Postsynaptic density membrane
CC       {ECO:0000250|UniProtKB:B5DFK7}.
CC   -!- PTM: Palmitoylated on cysteine residues located in a cysteine cluster
CC       at the N-terminus which promotes membrane localization.
CC       {ECO:0000250|UniProtKB:Q7M759}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD17 family.
CC       {ECO:0000305}.
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DR   EMBL; BC045350; AAH45350.1; -; mRNA.
DR   RefSeq; NP_956451.1; NM_200157.1.
DR   AlphaFoldDB; Q7ZVZ7; -.
DR   SMR; Q7ZVZ7; -.
DR   STRING; 7955.ENSDARP00000075766; -.
DR   ESTHER; danre-Q7ZVZ7; ABHD17-depalmitoylase.
DR   MEROPS; S09.053; -.
DR   PaxDb; Q7ZVZ7; -.
DR   PRIDE; Q7ZVZ7; -.
DR   Ensembl; ENSDART00000081323; ENSDARP00000075766; ENSDARG00000058452.
DR   Ensembl; ENSDART00000191288; ENSDARP00000144685; ENSDARG00000111161.
DR   GeneID; 393126; -.
DR   KEGG; dre:393126; -.
DR   CTD; 58489; -.
DR   ZFIN; ZDB-GENE-040426-714; abhd17c.
DR   eggNOG; KOG1552; Eukaryota.
DR   GeneTree; ENSGT00940000159424; -.
DR   HOGENOM; CLU_029375_5_4_1; -.
DR   InParanoid; Q7ZVZ7; -.
DR   OMA; GSRLNCN; -.
DR   OrthoDB; 629316at2759; -.
DR   PhylomeDB; Q7ZVZ7; -.
DR   TreeFam; TF314365; -.
DR   Reactome; R-DRE-9648002; RAS processing.
DR   PRO; PR:Q7ZVZ7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000058452; Expressed in cleaving embryo and 26 other tissues.
DR   ExpressionAtlas; Q7ZVZ7; baseline.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR   GO; GO:0002084; P:protein depalmitoylation; IBA:GO_Central.
DR   GO; GO:0099175; P:regulation of postsynapse organization; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022742; Hydrolase_4.
DR   Pfam; PF12146; Hydrolase_4; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Endosome; Hydrolase; Lipoprotein; Membrane;
KW   Palmitate; Postsynaptic cell membrane; Reference proteome; Synapse.
FT   CHAIN           1..294
FT                   /note="Alpha/beta hydrolase domain-containing protein 17C"
FT                   /id="PRO_0000297516"
FT   ACT_SITE        176
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS6"
FT   ACT_SITE        241
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:O75608"
FT   ACT_SITE        270
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:O75608"
SQ   SEQUENCE   294 AA;  32663 MW;  180E2AADFC07E896 CRC64;
     MPEQGPRMNS FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYSVHTDPSG ATSLHLTERA
     DWQYSQRELD AVEVLVTRTS RGNRVGCMFV RCAPASRYTL LFSHGNAVDL GQMCSFYIGL
     GSRINCNVFS YDYSGYGVST GKPSEKNLYA DIEAAWQVLR NKYGVTPENI ILYGQSIGTV
     PTVDLASRYE CAAVILHSPL MSGLRVAFPD TRKTYCFDAF PSIDKVSKVA SPVLVIHGTE
     DEVIDFSHGL AIYERCPRAV EPLWVEGAGH NDIELYAQYL ERLKQFITFE LATS