RM43_MOUSE
ID RM43_MOUSE Reviewed; 183 AA.
AC Q99N89;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=39S ribosomal protein L43, mitochondrial;
DE Short=L43mt;
DE Short=MRP-L43;
DE AltName: Full=Mitochondrial ribosomal protein bMRP36a;
DE Flags: Precursor;
GN Name=Mrpl43;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [2]
RP TISSUE SPECIFICITY, AND COREGULATION WITH TWNK.
RX PubMed=15509589; DOI=10.1093/hmg/ddh342;
RA Tyynismaa H., Sembongi H., Bokori-Brown M., Granycome C., Ashley N.,
RA Poulton J., Jalanko A., Spelbrink J.N., Holt I.J., Suomalainen A.;
RT "Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA
RT copy number.";
RL Hum. Mol. Genet. 13:3219-3227(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q8N983}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069}.
CC -!- TISSUE SPECIFICITY: Ubiquitous with the highest levels in the liver,
CC heart and kidneys. The skeletal muscle, brain and testis showed lower
CC but detectable expression. Expression is coregulated with TWNK.
CC {ECO:0000269|PubMed:15509589}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL43 family. {ECO:0000305}.
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DR EMBL; AB049657; BAB40862.1; -; mRNA.
DR AlphaFoldDB; Q99N89; -.
DR SMR; Q99N89; -.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000095322; -.
DR PhosphoSitePlus; Q99N89; -.
DR EPD; Q99N89; -.
DR MaxQB; Q99N89; -.
DR PaxDb; Q99N89; -.
DR PeptideAtlas; Q99N89; -.
DR PRIDE; Q99N89; -.
DR ProteomicsDB; 299861; -.
DR MGI; MGI:2137229; Mrpl43.
DR eggNOG; KOG3445; Eukaryota.
DR InParanoid; Q99N89; -.
DR PhylomeDB; Q99N89; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR ChiTaRS; Mrpl43; mouse.
DR PRO; PR:Q99N89; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q99N89; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISO:MGI.
DR InterPro; IPR039927; MRPL43/MRPL51.
DR InterPro; IPR007741; Ribosome/NADH_DH.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR21396; PTHR21396; 1.
DR Pfam; PF05047; L51_S25_CI-B8; 1.
DR SMART; SM00916; L51_S25_CI-B8; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..183
FT /note="39S ribosomal protein L43, mitochondrial"
FT /id="PRO_0000030562"
FT REGION 120..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 183 AA; 20203 MW; ECBB4AE659EC7272 CRC64;
MTGRGTSSRF LTSVLHNGLG RYVQQLQRLS LSLSRDAPSS RGAREFVERE VTDFARRNPG
VVVYVNPRPC AMPRIVAEYL NGAVREENVN SKSVEEIKSL VQKLADQSGL DVIRIRKPFH
TDNPSIQGQW TPSPTNGLPS TGCGPENSGI LLQLRCKHSK EPGALDRERD RIGSSFGFQA
QAE
