RM45_DROME
ID RM45_DROME Reviewed; 361 AA.
AC Q9VCX3;
DT 04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Probable 39S ribosomal protein L45, mitochondrial;
DE Short=L45mt;
DE Short=MRP-L45;
DE Flags: Precursor;
GN Name=mRpL45; ORFNames=CG6949;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL45 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF56032.1; -; Genomic_DNA.
DR EMBL; AY071013; AAL48635.1; -; mRNA.
DR RefSeq; NP_651072.1; NM_142815.4.
DR AlphaFoldDB; Q9VCX3; -.
DR SMR; Q9VCX3; -.
DR BioGRID; 67623; 3.
DR DIP; DIP-23683N; -.
DR IntAct; Q9VCX3; 6.
DR STRING; 7227.FBpp0083665; -.
DR PaxDb; Q9VCX3; -.
DR PRIDE; Q9VCX3; -.
DR DNASU; 42671; -.
DR EnsemblMetazoa; FBtr0084272; FBpp0083665; FBgn0263863.
DR GeneID; 42671; -.
DR KEGG; dme:Dmel_CG6949; -.
DR CTD; 84311; -.
DR FlyBase; FBgn0263863; mRpL45.
DR VEuPathDB; VectorBase:FBgn0263863; -.
DR eggNOG; KOG4599; Eukaryota.
DR GeneTree; ENSGT00390000012679; -.
DR HOGENOM; CLU_038409_1_1_1; -.
DR InParanoid; Q9VCX3; -.
DR OMA; HTHMAAK; -.
DR OrthoDB; 1121890at2759; -.
DR PhylomeDB; Q9VCX3; -.
DR Reactome; R-DME-5389840; Mitochondrial translation elongation.
DR Reactome; R-DME-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 42671; 0 hits in 1 CRISPR screen.
DR ChiTaRS; mRpL45; fly.
DR GenomeRNAi; 42671; -.
DR PRO; PR:Q9VCX3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0263863; Expressed in adult Malpighian tubule (Drosophila) and 53 other tissues.
DR Genevisible; Q9VCX3; DM.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; TAS:FlyBase.
DR GO; GO:0032543; P:mitochondrial translation; TAS:FlyBase.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR007379; Tim44-like_dom.
DR Pfam; PF04280; Tim44; 1.
DR SMART; SM00978; Tim44; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..361
FT /note="Probable 39S ribosomal protein L45, mitochondrial"
FT /id="PRO_0000030566"
FT REGION 319..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 41611 MW; F0EE800484E4F6D4 CRC64;
MEKLASAKTC LKLLQVMPGV QQAALLPGGG LGVLASPLQN LIQMQQVRHR QTKHWKPEFK
RLRKLKFVKM DLPNLREKQE DITKEEMRSR MKERGVLPPR PWMERPFHIS CTGGIFEAYV
PPEGDGKKSI ISTSGAKQKL EFLEKKSKSL MAVRKIRSYD ENFSSDDFGA EAQDIYIQAH
THMAAKDKYK IREFVSERCY PEMMHNVKDK TIRWKFLQSL EPPRVVHARV TEVITKENQF
AQVTVRFHSQ QMLAIYDRFG RLMHGSEIIT KDVLEYVVFE KHISNEYGKW RLHDKIIPDW
LPAKQPAPIT YRLIEDAEEP PKELSAGDAE VKQVDSVGEQ SKEQLPLATP VESHTKPSLA
I
