ID   RM45_MOUSE              Reviewed;         306 AA.
AC   Q9D0Q7; Q3TZL8; Q8VDW2;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=39S ribosomal protein L45, mitochondrial;
DE            Short=L45mt;
DE            Short=MRP-L45;
DE   Flags: Precursor;
GN   Name=Mrpl45;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC       which comprises a 16S rRNA and about 50 distinct proteins.
CC       {ECO:0000250|UniProtKB:Q9BRJ2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BRJ2}.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mL45 family. {ECO:0000305}.
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DR   EMBL; AK011163; BAB27440.1; -; mRNA.
DR   EMBL; AK081922; BAC38375.1; -; mRNA.
DR   EMBL; AK157771; BAE34190.1; -; mRNA.
DR   EMBL; BC020130; AAH20130.1; -; mRNA.
DR   CCDS; CCDS25318.1; -.
DR   RefSeq; NP_080203.1; NM_025927.4.
DR   AlphaFoldDB; Q9D0Q7; -.
DR   SMR; Q9D0Q7; -.
DR   BioGRID; 211890; 28.
DR   ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR   STRING; 10090.ENSMUSP00000019026; -.
DR   iPTMnet; Q9D0Q7; -.
DR   PhosphoSitePlus; Q9D0Q7; -.
DR   EPD; Q9D0Q7; -.
DR   MaxQB; Q9D0Q7; -.
DR   PaxDb; Q9D0Q7; -.
DR   PeptideAtlas; Q9D0Q7; -.
DR   PRIDE; Q9D0Q7; -.
DR   ProteomicsDB; 300404; -.
DR   Antibodypedia; 73371; 148 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000019026; ENSMUSP00000019026; ENSMUSG00000018882.
DR   GeneID; 67036; -.
DR   KEGG; mmu:67036; -.
DR   UCSC; uc007ldx.2; mouse.
DR   CTD; 84311; -.
DR   MGI; MGI:1914286; Mrpl45.
DR   VEuPathDB; HostDB:ENSMUSG00000018882; -.
DR   eggNOG; KOG4599; Eukaryota.
DR   GeneTree; ENSGT00390000012679; -.
DR   HOGENOM; CLU_038409_0_0_1; -.
DR   InParanoid; Q9D0Q7; -.
DR   OMA; HPIPLYL; -.
DR   OrthoDB; 1121890at2759; -.
DR   PhylomeDB; Q9D0Q7; -.
DR   TreeFam; TF105825; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 67036; 26 hits in 71 CRISPR screens.
DR   ChiTaRS; Mrpl45; mouse.
DR   PRO; PR:Q9D0Q7; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q9D0Q7; protein.
DR   Bgee; ENSMUSG00000018882; Expressed in ileal epithelium and 253 other tissues.
DR   ExpressionAtlas; Q9D0Q7; baseline and differential.
DR   Genevisible; Q9D0Q7; MM.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR007379; Tim44-like_dom.
DR   Pfam; PF04280; Tim44; 1.
DR   SMART; SM00978; Tim44; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..306
FT                   /note="39S ribosomal protein L45, mitochondrial"
FT                   /id="PRO_0000030564"
FT   CONFLICT        130
FT                   /note="A -> T (in Ref. 2; AAH20130)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   306 AA;  35411 MW;  6476F542371FE5DC CRC64;
     MAAPVPRGLS SLYRTLGWWS RQPILVTQST TVVQVKTKSR FRPPTPEPKY KTEKEFLEYA
     RKAGLVIPQE RLERPIHLAC TAGIFDPYVP PEGDARMSSL SKEGLTQRTE RLRKNAASQL
     AIRKIREFDA NFKTKDFPEK AKDIFIEAHL CLNNSDHDRL HTLVTEHCFP DMVWDLKYKT
     VRWGFVESLE PAQVVHVRCS GLVNQSNMYG QVTVRLHTRQ TLAIYDRFGR LMYGQEDVPK
     DVLEYVVFER HLMNPYGSWR MHAKIVPAWA PPKQPILKTL MIPGPQLKPW EEYEETQGEA
     QKPQLA