RM46_MOUSE
ID RM46_MOUSE Reviewed; 283 AA.
AC Q9EQI8;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=39S ribosomal protein L46, mitochondrial;
DE Short=L46mt;
DE Short=MRP-L46;
DE Flags: Precursor;
GN Name=Mrpl46;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11761714; DOI=10.3109/10425170109047561;
RA Carim-Todd L., Sumoy L., Andreu N., Estivill X., Escarceller M.;
RT "Cloning, mapping and expression analysis of C15orf4, a novel human gene
RT with homology to the yeast mitochondrial ribosomal protein Ym130 gene.";
RL DNA Seq. 12:91-96(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-217 AND LYS-246, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q9H2W6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9H2W6}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL46 family. {ECO:0000305}.
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DR EMBL; AF217090; AAG44099.1; -; mRNA.
DR EMBL; BC061094; AAH61094.1; -; mRNA.
DR CCDS; CCDS21373.1; -.
DR RefSeq; NP_075820.1; NM_023331.2.
DR AlphaFoldDB; Q9EQI8; -.
DR SMR; Q9EQI8; -.
DR BioGRID; 212093; 28.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000032841; -.
DR iPTMnet; Q9EQI8; -.
DR PhosphoSitePlus; Q9EQI8; -.
DR EPD; Q9EQI8; -.
DR jPOST; Q9EQI8; -.
DR MaxQB; Q9EQI8; -.
DR PaxDb; Q9EQI8; -.
DR PeptideAtlas; Q9EQI8; -.
DR PRIDE; Q9EQI8; -.
DR ProteomicsDB; 299833; -.
DR Antibodypedia; 58578; 193 antibodies from 27 providers.
DR DNASU; 67308; -.
DR Ensembl; ENSMUST00000032841; ENSMUSP00000032841; ENSMUSG00000030612.
DR GeneID; 67308; -.
DR KEGG; mmu:67308; -.
DR UCSC; uc009hxl.1; mouse.
DR CTD; 26589; -.
DR MGI; MGI:1914558; Mrpl46.
DR VEuPathDB; HostDB:ENSMUSG00000030612; -.
DR eggNOG; KOG4548; Eukaryota.
DR GeneTree; ENSGT00390000015400; -.
DR HOGENOM; CLU_079736_1_0_1; -.
DR InParanoid; Q9EQI8; -.
DR OMA; NNMEAKF; -.
DR OrthoDB; 1527405at2759; -.
DR PhylomeDB; Q9EQI8; -.
DR TreeFam; TF324756; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 67308; 26 hits in 73 CRISPR screens.
DR ChiTaRS; Mrpl46; mouse.
DR PRO; PR:Q9EQI8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9EQI8; protein.
DR Bgee; ENSMUSG00000030612; Expressed in facial nucleus and 260 other tissues.
DR Genevisible; Q9EQI8; MM.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR CDD; cd04661; MRP_L46; 1.
DR InterPro; IPR033650; MRP_L46_NUDIX.
DR InterPro; IPR040008; MRPL46.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR021757; Ribosomal_L46_N.
DR PANTHER; PTHR13124; PTHR13124; 1.
DR Pfam; PF11788; MRP-L46; 1.
DR SUPFAM; SSF55811; SSF55811; 1.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..283
FT /note="39S ribosomal protein L46, mitochondrial"
FT /id="PRO_0000030577"
FT MOD_RES 217
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 228
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2W6"
FT MOD_RES 246
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
SQ SEQUENCE 283 AA; 32132 MW; BF715A364CCE53B9 CRC64;
MAAPVGRTLL GLARGWRQLD RFWAGSSRGL SLEAASSSSR SPWRLSGALC LQRPPLITKA
LTPLQEEMAG LLQQIEVERS LYSDHELRAL DEAQRLAKKK ADLYDEEQEQ GITLAQDLED
MWEQAFLQFR PGARETEADK KNDRTSLHRK LDRNLVLLVR EKLGDQDVWM LPQVEWQPGE
TLRGTAERIL ATLSENNMEA KFLGNAPCGH YKFKFPKAIQ TESDLGVKVF FFKALLLTGD
FVQAGKKSRH VWASKEELGD YLQPKYLAQV RRFLLDSDGL SCL
