RM46_RAT
ID RM46_RAT Reviewed; 277 AA.
AC Q5RK00;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=39S ribosomal protein L46, mitochondrial;
DE Short=L46mt;
DE Short=MRP-L46;
DE Flags: Precursor;
GN Name=Mrpl46;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q9H2W6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9H2W6}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL46 family. {ECO:0000305}.
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DR EMBL; BC086407; AAH86407.1; -; mRNA.
DR RefSeq; NP_001013086.1; NM_001013068.1.
DR AlphaFoldDB; Q5RK00; -.
DR SMR; Q5RK00; -.
DR IntAct; Q5RK00; 6.
DR STRING; 10116.ENSRNOP00000061438; -.
DR jPOST; Q5RK00; -.
DR PaxDb; Q5RK00; -.
DR PRIDE; Q5RK00; -.
DR Ensembl; ENSRNOT00000067172; ENSRNOP00000061438; ENSRNOG00000018547.
DR GeneID; 293054; -.
DR KEGG; rno:293054; -.
DR UCSC; RGD:1309123; rat.
DR CTD; 26589; -.
DR RGD; 1309123; Mrpl46.
DR eggNOG; KOG4548; Eukaryota.
DR GeneTree; ENSGT00390000015400; -.
DR HOGENOM; CLU_079736_1_0_1; -.
DR InParanoid; Q5RK00; -.
DR OMA; NNMEAKF; -.
DR OrthoDB; 1527405at2759; -.
DR Reactome; R-RNO-5389840; Mitochondrial translation elongation.
DR Reactome; R-RNO-5419276; Mitochondrial translation termination.
DR PRO; PR:Q5RK00; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000018547; Expressed in heart and 20 other tissues.
DR Genevisible; Q5RK00; RN.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR CDD; cd04661; MRP_L46; 1.
DR InterPro; IPR033650; MRP_L46_NUDIX.
DR InterPro; IPR040008; MRPL46.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR021757; Ribosomal_L46_N.
DR PANTHER; PTHR13124; PTHR13124; 1.
DR Pfam; PF11788; MRP-L46; 1.
DR SUPFAM; SSF55811; SSF55811; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..277
FT /note="39S ribosomal protein L46, mitochondrial"
FT /id="PRO_0000273556"
FT MOD_RES 217
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQI8"
FT MOD_RES 228
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9H2W6"
FT MOD_RES 246
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQI8"
SQ SEQUENCE 277 AA; 31673 MW; 07612893DD4D1083 CRC64;
MAAPIGRTLL GVAKGWRQLD RLWAGSSRGL SLEAAPSSSR SPWRLSGALC LQRPPLITKP
LTPLQEEMAG LLQQVEVERS LYSDHELRAL DEAQRLAKKK ADLYDEEQDQ DVTLAQDLED
MWEQEFLQFR PGARETEADK KNDRTSLHRK LDRNLILLVR EKLGDQDLWM LPQVEWQPGE
TLRGTAERIL ATLSENNMEA KFLGNAPCGH YKFKFPKAIR TESDLGVKVF FFKALLLTGD
FVQTGKKGRH VWASKEELGD YLQPKYLAQV RRFLLDL
