RM49_MOUSE
ID RM49_MOUSE Reviewed; 166 AA.
AC Q9CQ40; Q3UC21; Q8C5R0; Q8C7P3;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=39S ribosomal protein L49, mitochondrial;
DE Short=L49mt;
DE Short=MRP-L49;
GN Name=Mrpl49;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Head, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins (By
CC similarity). Interacts with OXA1L (By similarity).
CC {ECO:0000250|UniProtKB:Q13405, ECO:0000250|UniProtKB:Q5EA71}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q13405}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL49 family. {ECO:0000305}.
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DR EMBL; AK007712; BAB25205.1; -; mRNA.
DR EMBL; AK014723; BAB29520.1; -; mRNA.
DR EMBL; AK027949; BAC25678.1; -; mRNA.
DR EMBL; AK049794; BAC33922.1; -; mRNA.
DR EMBL; AK077397; BAC36782.1; -; mRNA.
DR EMBL; AK150572; BAE29667.1; -; mRNA.
DR EMBL; AK150715; BAE29793.1; -; mRNA.
DR EMBL; BC028956; AAH28956.1; -; mRNA.
DR CCDS; CCDS29488.1; -.
DR RefSeq; NP_080522.1; NM_026246.3.
DR AlphaFoldDB; Q9CQ40; -.
DR SMR; Q9CQ40; -.
DR BioGRID; 201802; 34.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000007482; -.
DR PhosphoSitePlus; Q9CQ40; -.
DR EPD; Q9CQ40; -.
DR jPOST; Q9CQ40; -.
DR MaxQB; Q9CQ40; -.
DR PaxDb; Q9CQ40; -.
DR PeptideAtlas; Q9CQ40; -.
DR PRIDE; Q9CQ40; -.
DR ProteomicsDB; 299864; -.
DR Antibodypedia; 29687; 130 antibodies from 23 providers.
DR DNASU; 18120; -.
DR Ensembl; ENSMUST00000007482; ENSMUSP00000007482; ENSMUSG00000007338.
DR GeneID; 18120; -.
DR KEGG; mmu:18120; -.
DR UCSC; uc008ggq.1; mouse.
DR CTD; 740; -.
DR MGI; MGI:108180; Mrpl49.
DR VEuPathDB; HostDB:ENSMUSG00000007338; -.
DR eggNOG; KOG4034; Eukaryota.
DR GeneTree; ENSGT00390000017253; -.
DR HOGENOM; CLU_085757_2_3_1; -.
DR InParanoid; Q9CQ40; -.
DR OMA; NPPEWKY; -.
DR OrthoDB; 1534017at2759; -.
DR PhylomeDB; Q9CQ40; -.
DR TreeFam; TF317750; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 18120; 21 hits in 75 CRISPR screens.
DR PRO; PR:Q9CQ40; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9CQ40; protein.
DR Bgee; ENSMUSG00000007338; Expressed in yolk sac and 250 other tissues.
DR ExpressionAtlas; Q9CQ40; baseline and differential.
DR Genevisible; Q9CQ40; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR007740; Ribosomal_L49/IMG2.
DR PANTHER; PTHR13477; PTHR13477; 1.
DR Pfam; PF05046; Img2; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..166
FT /note="39S ribosomal protein L49, mitochondrial"
FT /id="PRO_0000207666"
FT REGION 54..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 152
FT /note="Y -> N (in Ref. 1; BAC33922)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 19133 MW; CCF652F8403DA229 CRC64;
MAAAVLRAAL QDWRSCLGRS YGRRKLSQTQ GPPDNPGFVE SVDEYQFVER LLPPTKIPEP
PKHKHYPTPS GWQPPRDPLP SLPYFVRRSR MHNIPVYKEI THGNRQMTLI RKVEGDIWAL
QKDVEEFLSP LLGKTPITQV NEVTGTLRIK GYFDEQLKAW LLEKGF
