RM52_HUMAN
ID RM52_HUMAN Reviewed; 123 AA.
AC Q86TS9; A6NMQ8; A8MXK5; A8MYI6; G3XCN9; Q6NVH8;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=39S ribosomal protein L52, mitochondrial;
DE Short=L52mt;
DE Short=MRP-L52;
DE AltName: Full=Mitochondrial large ribosomal subunit protein mL52 {ECO:0000303|PubMed:25278503};
DE Flags: Precursor;
GN Name=MRPL52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT ALA-19.
RC TISSUE=Liver;
RA Xu C.S.;
RT "Liver regeneration after partial hepatectomy.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ALA-19.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=11551941; DOI=10.1074/jbc.m106510200;
RA Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M.,
RA Moseley A., Spremulli L.L.;
RT "The large subunit of the mammalian mitochondrial ribosome. Analysis of the
RT complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:43958-43969(2001).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [8] {ECO:0007744|PDB:3J7Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS) OF 6-123, SUBCELLULAR
RP LOCATION, AND SUBUNIT.
RX PubMed=25278503; DOI=10.1126/science.1258026;
RA Brown A., Amunts A., Bai X.C., Sugimoto Y., Edwards P.C., Murshudov G.,
RA Scheres S.H., Ramakrishnan V.;
RT "Structure of the large ribosomal subunit from human mitochondria.";
RL Science 346:718-722(2014).
RN [9] {ECO:0007744|PDB:5OOL, ECO:0007744|PDB:5OOM}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=28892042; DOI=10.1038/nsmb.3464;
RA Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J.,
RA Amunts A., Ramakrishnan V.;
RT "Structures of the human mitochondrial ribosome in native states of
RT assembly.";
RL Nat. Struct. Mol. Biol. 24:866-869(2017).
CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC LSU) (PubMed:28892042, PubMed:25278503). Mature mammalian 55S
CC mitochondrial ribosomes consist of a small (28S) and a large (39S)
CC subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-
CC rRNA) and 30 different proteins. The 39S large subunit contains a 16S
CC rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-
CC tRNA(Val)), which plays an integral structural role, and 52 different
CC proteins. mL52 connects the central protuberance to the body of the
CC ribosome. {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:28892042}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86TS9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86TS9-2; Sequence=VSP_044560;
CC Name=3;
CC IsoId=Q86TS9-3; Sequence=VSP_045242;
CC Name=4;
CC IsoId=Q86TS9-4; Sequence=VSP_054094, VSP_054095;
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL52 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD66556.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DW429620; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX248749; CAD66556.1; ALT_INIT; mRNA.
DR EMBL; AL135998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW66238.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66240.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66241.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66242.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66244.1; -; Genomic_DNA.
DR EMBL; BC068070; AAH68070.1; -; mRNA.
DR EMBL; BU600884; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS41917.1; -. [Q86TS9-1]
DR CCDS; CCDS41918.1; -. [Q86TS9-2]
DR CCDS; CCDS9575.1; -. [Q86TS9-3]
DR CCDS; CCDS9576.1; -. [Q86TS9-4]
DR RefSeq; NP_848026.1; NM_178336.2. [Q86TS9-1]
DR RefSeq; NP_851313.1; NM_180982.2. [Q86TS9-3]
DR RefSeq; NP_851821.1; NM_181304.2. [Q86TS9-2]
DR RefSeq; NP_851822.1; NM_181305.2. [Q86TS9-2]
DR RefSeq; NP_851823.1; NM_181306.2. [Q86TS9-2]
DR RefSeq; NP_851824.1; NM_181307.2. [Q86TS9-4]
DR RefSeq; XP_005267385.1; XM_005267328.3. [Q86TS9-2]
DR PDB; 3J7Y; EM; 3.40 A; j=6-123.
DR PDB; 5OOL; EM; 3.06 A; j=1-123.
DR PDB; 5OOM; EM; 3.03 A; j=1-123.
DR PDB; 6NU2; EM; 3.90 A; j=24-108.
DR PDB; 6NU3; EM; 4.40 A; j=1-123.
DR PDB; 6ZM5; EM; 2.89 A; j=1-123.
DR PDB; 6ZM6; EM; 2.59 A; j=1-123.
DR PDB; 6ZSA; EM; 4.00 A; j=1-123.
DR PDB; 6ZSB; EM; 4.50 A; j=1-123.
DR PDB; 6ZSC; EM; 3.50 A; j=1-123.
DR PDB; 6ZSD; EM; 3.70 A; j=1-123.
DR PDB; 6ZSE; EM; 5.00 A; j=1-123.
DR PDB; 6ZSG; EM; 4.00 A; j=1-123.
DR PDB; 7A5F; EM; 4.40 A; j3=1-123.
DR PDB; 7A5G; EM; 4.33 A; j3=1-123.
DR PDB; 7O9K; EM; 3.10 A; j=1-123.
DR PDB; 7O9M; EM; 2.50 A; j=1-123.
DR PDB; 7ODR; EM; 2.90 A; j=1-123.
DR PDB; 7ODS; EM; 3.10 A; j=1-123.
DR PDB; 7ODT; EM; 3.10 A; j=1-123.
DR PDB; 7OF0; EM; 2.20 A; j=1-123.
DR PDB; 7OF2; EM; 2.70 A; j=1-123.
DR PDB; 7OF3; EM; 2.70 A; j=1-123.
DR PDB; 7OF4; EM; 2.70 A; j=1-123.
DR PDB; 7OF5; EM; 2.90 A; j=1-123.
DR PDB; 7OF6; EM; 2.60 A; j=1-123.
DR PDB; 7OF7; EM; 2.50 A; j=24-108.
DR PDB; 7OG4; EM; 3.80 A; j=1-123.
DR PDB; 7OI6; EM; 5.70 A; j=1-123.
DR PDB; 7OI7; EM; 3.50 A; j=1-123.
DR PDB; 7OI8; EM; 3.50 A; j=1-123.
DR PDB; 7OI9; EM; 3.30 A; j=1-123.
DR PDB; 7OIA; EM; 3.20 A; j=1-123.
DR PDB; 7OIB; EM; 3.30 A; j=1-123.
DR PDB; 7OIC; EM; 3.10 A; j=1-123.
DR PDB; 7OID; EM; 3.70 A; j=1-123.
DR PDB; 7OIE; EM; 3.50 A; j=1-123.
DR PDB; 7PD3; EM; 3.40 A; j=1-123.
DR PDB; 7QH6; EM; 3.08 A; j=1-123.
DR PDBsum; 3J7Y; -.
DR PDBsum; 5OOL; -.
DR PDBsum; 5OOM; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7O9K; -.
DR PDBsum; 7O9M; -.
DR PDBsum; 7ODR; -.
DR PDBsum; 7ODS; -.
DR PDBsum; 7ODT; -.
DR PDBsum; 7OF0; -.
DR PDBsum; 7OF2; -.
DR PDBsum; 7OF3; -.
DR PDBsum; 7OF4; -.
DR PDBsum; 7OF5; -.
DR PDBsum; 7OF6; -.
DR PDBsum; 7OF7; -.
DR PDBsum; 7OG4; -.
DR PDBsum; 7OI6; -.
DR PDBsum; 7OI7; -.
DR PDBsum; 7OI8; -.
DR PDBsum; 7OI9; -.
DR PDBsum; 7OIA; -.
DR PDBsum; 7OIB; -.
DR PDBsum; 7OIC; -.
DR PDBsum; 7OID; -.
DR PDBsum; 7OIE; -.
DR PDBsum; 7PD3; -.
DR PDBsum; 7QH6; -.
DR AlphaFoldDB; Q86TS9; -.
DR SMR; Q86TS9; -.
DR BioGRID; 125788; 171.
DR ComplexPortal; CPX-5226; 39S mitochondrial large ribosomal subunit.
DR CORUM; Q86TS9; -.
DR IntAct; Q86TS9; 20.
DR MINT; Q86TS9; -.
DR STRING; 9606.ENSP00000347277; -.
DR iPTMnet; Q86TS9; -.
DR PhosphoSitePlus; Q86TS9; -.
DR BioMuta; MRPL52; -.
DR DMDM; 124053357; -.
DR EPD; Q86TS9; -.
DR jPOST; Q86TS9; -.
DR MassIVE; Q86TS9; -.
DR MaxQB; Q86TS9; -.
DR PaxDb; Q86TS9; -.
DR PeptideAtlas; Q86TS9; -.
DR PRIDE; Q86TS9; -.
DR ProteomicsDB; 1555; -.
DR ProteomicsDB; 33809; -.
DR ProteomicsDB; 69730; -. [Q86TS9-1]
DR TopDownProteomics; Q86TS9-1; -. [Q86TS9-1]
DR TopDownProteomics; Q86TS9-3; -. [Q86TS9-3]
DR Antibodypedia; 194; 70 antibodies from 22 providers.
DR DNASU; 122704; -.
DR Ensembl; ENST00000355151.9; ENSP00000347277.5; ENSG00000172590.18. [Q86TS9-1]
DR Ensembl; ENST00000397496.7; ENSP00000380633.3; ENSG00000172590.18. [Q86TS9-3]
DR Ensembl; ENST00000397505.2; ENSP00000380642.2; ENSG00000172590.18. [Q86TS9-4]
DR Ensembl; ENST00000553711.5; ENSP00000451303.1; ENSG00000172590.18. [Q86TS9-2]
DR Ensembl; ENST00000555345.5; ENSP00000451081.1; ENSG00000172590.18. [Q86TS9-2]
DR Ensembl; ENST00000556840.5; ENSP00000451481.1; ENSG00000172590.18. [Q86TS9-2]
DR GeneID; 122704; -.
DR KEGG; hsa:122704; -.
DR MANE-Select; ENST00000397496.7; ENSP00000380633.3; NM_180982.3; NP_851313.1. [Q86TS9-3]
DR UCSC; uc001wgw.4; human. [Q86TS9-1]
DR CTD; 122704; -.
DR GeneCards; MRPL52; -.
DR HGNC; HGNC:16655; MRPL52.
DR HPA; ENSG00000172590; Low tissue specificity.
DR MIM; 611856; gene.
DR neXtProt; NX_Q86TS9; -.
DR OpenTargets; ENSG00000172590; -.
DR PharmGKB; PA30985; -.
DR VEuPathDB; HostDB:ENSG00000172590; -.
DR eggNOG; ENOG502S4I0; Eukaryota.
DR GeneTree; ENSGT00390000005763; -.
DR HOGENOM; CLU_135844_0_0_1; -.
DR InParanoid; Q86TS9; -.
DR OMA; PLGANQK; -.
DR OrthoDB; 1623574at2759; -.
DR PhylomeDB; Q86TS9; -.
DR TreeFam; TF323872; -.
DR PathwayCommons; Q86TS9; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q86TS9; -.
DR SIGNOR; Q86TS9; -.
DR BioGRID-ORCS; 122704; 69 hits in 1091 CRISPR screens.
DR ChiTaRS; MRPL52; human.
DR GenomeRNAi; 122704; -.
DR Pharos; Q86TS9; Tdark.
DR PRO; PR:Q86TS9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q86TS9; protein.
DR Bgee; ENSG00000172590; Expressed in mucosa of transverse colon and 185 other tissues.
DR ExpressionAtlas; Q86TS9; baseline and differential.
DR Genevisible; Q86TS9; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISS:UniProtKB.
DR InterPro; IPR034596; MRPL52.
DR PANTHER; PTHR34090; PTHR34090; 1.
DR Pfam; PF18699; MRPL52; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..23
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 24..123
FT /note="39S ribosomal protein L52, mitochondrial"
FT /id="PRO_0000273093"
FT REGION 99..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044560"
FT VAR_SEQ 10..11
FT /note="TG -> S (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_045242"
FT VAR_SEQ 53..87
FT /note="DGRPAPPMKGQLRRKAERETFARRVVLLSQEMDAG -> ETSCTAVTGNGRW
FT ITSMAAQAAEVAGRTKEAGKCS (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_054094"
FT VAR_SEQ 88..123
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_054095"
FT VARIANT 5
FT /note="G -> V (in dbSNP:rs1135641)"
FT /id="VAR_030080"
FT VARIANT 19
FT /note="V -> A (in dbSNP:rs4982685)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_030081"
FT VARIANT 104
FT /note="K -> R (in dbSNP:rs11538931)"
FT /id="VAR_052044"
FT CONFLICT 49
FT /note="W -> C (in Ref. 5; AAH68070)"
FT /evidence="ECO:0000305"
FT HELIX 25..30
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 42..45
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 48..51
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 61..104
FT /evidence="ECO:0007829|PDB:7OF0"
SQ SEQUENCE 123 AA; 13664 MW; A67803930E27E4EE CRC64;
MAALGTVLFT GVRRLHCSVA AWAGGQWRLQ QGLAANPSGY GPLTELPDWS YADGRPAPPM
KGQLRRKAER ETFARRVVLL SQEMDAGLQA WQLRQQKLQE EQRKQENALK PKGASLKSPL
PSQ
