RM55_DROME
ID RM55_DROME Reviewed; 107 AA.
AC Q9VE04;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=39S ribosomal protein L55, mitochondrial;
DE Short=L55mt;
DE Short=MRP-L55;
DE Flags: Precursor;
GN Name=mRpL55; ORFNames=CG14283;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=15894314; DOI=10.1016/j.yexcr.2005.03.037;
RA Tselykh T.V., Roos C., Heino T.I.;
RT "The mitochondrial ribosome-specific MrpL55 protein is essential in
RT Drosophila and dynamically required during development.";
RL Exp. Cell Res. 307:354-366(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Involved in mitochondrial biogenesis and G2/M phase cell
CC cycle progression. {ECO:0000269|PubMed:15894314}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15894314}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed (at protein level).
CC {ECO:0000269|PubMed:15894314}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed throughout embryogenesis. {ECO:0000269|PubMed:15894314}.
CC -!- DISRUPTION PHENOTYPE: Flies do not grow after hatching, moved slowly
CC and died as first instar larvae. {ECO:0000269|PubMed:15894314}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL55 family. {ECO:0000305}.
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DR EMBL; AJ278709; CAB99479.1; -; mRNA.
DR EMBL; AE014297; AAF55632.1; -; Genomic_DNA.
DR EMBL; AY071686; AAL49308.1; -; mRNA.
DR RefSeq; NP_650780.1; NM_142523.4.
DR AlphaFoldDB; Q9VE04; -.
DR SMR; Q9VE04; -.
DR BioGRID; 67288; 1.
DR IntAct; Q9VE04; 1.
DR STRING; 7227.FBpp0083168; -.
DR PaxDb; Q9VE04; -.
DR PRIDE; Q9VE04; -.
DR DNASU; 42290; -.
DR EnsemblMetazoa; FBtr0083754; FBpp0083168; FBgn0038678.
DR GeneID; 42290; -.
DR KEGG; dme:Dmel_CG14283; -.
DR CTD; 128308; -.
DR FlyBase; FBgn0038678; mRpL55.
DR VEuPathDB; VectorBase:FBgn0038678; -.
DR eggNOG; KOG4616; Eukaryota.
DR GeneTree; ENSGT00940000169038; -.
DR HOGENOM; CLU_139855_1_0_1; -.
DR InParanoid; Q9VE04; -.
DR OMA; INVRYHE; -.
DR OrthoDB; 1553019at2759; -.
DR PhylomeDB; Q9VE04; -.
DR Reactome; R-DME-5389840; Mitochondrial translation elongation.
DR Reactome; R-DME-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 42290; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 42290; -.
DR PRO; PR:Q9VE04; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038678; Expressed in Malpighian tubule and 16 other tissues.
DR ExpressionAtlas; Q9VE04; baseline and differential.
DR Genevisible; Q9VE04; DM.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; TAS:FlyBase.
DR GO; GO:0006412; P:translation; ISS:UniProtKB.
DR Gene3D; 6.20.130.20; -; 1.
DR InterPro; IPR018615; Ribosomal_L55_mit.
DR InterPro; IPR044884; Ribosomal_L55_sf.
DR PANTHER; PTHR34095; PTHR34095; 1.
DR Pfam; PF09776; Mitoc_L55; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..16
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 17..107
FT /note="39S ribosomal protein L55, mitochondrial"
FT /id="PRO_0000273101"
SQ SEQUENCE 107 AA; 12568 MW; 6E93D5DE48BCB853 CRC64;
MLLKQLPQAV QQIRCISSAT TAVTRLHRSV YCRLYPTVVV QPDGSTINIR YHEPRKIIKL
PLDLSTLTDA ERRARLEARK PRKKVKIMEE VEDNFNAKKY MKYIKKK
