RM55_MOUSE
ID RM55_MOUSE Reviewed; 127 AA.
AC Q9CZ83; Q8R030;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=39S ribosomal protein L55, mitochondrial;
DE Short=L55mt;
DE Short=MRP-L55;
DE Flags: Precursor;
GN Name=Mrpl55;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:P0C2B8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P0C2B8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CZ83-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CZ83-2; Sequence=VSP_022478;
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL55 family. {ECO:0000305}.
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DR EMBL; AK012885; BAB28535.1; -; mRNA.
DR EMBL; BC028538; AAH28538.1; -; mRNA.
DR CCDS; CCDS24763.1; -. [Q9CZ83-1]
DR CCDS; CCDS78955.1; -. [Q9CZ83-2]
DR RefSeq; NP_001289263.1; NM_001302334.1. [Q9CZ83-2]
DR RefSeq; NP_001289264.1; NM_001302335.1. [Q9CZ83-2]
DR RefSeq; NP_001289265.1; NM_001302336.1. [Q9CZ83-1]
DR RefSeq; NP_080311.1; NM_026035.3. [Q9CZ83-1]
DR RefSeq; XP_006534035.1; XM_006533972.2.
DR RefSeq; XP_006534037.1; XM_006533974.3. [Q9CZ83-2]
DR RefSeq; XP_006534038.1; XM_006533975.3. [Q9CZ83-2]
DR RefSeq; XP_006534039.1; XM_006533976.3. [Q9CZ83-2]
DR RefSeq; XP_006534041.1; XM_006533978.3.
DR AlphaFoldDB; Q9CZ83; -.
DR SMR; Q9CZ83; -.
DR BioGRID; 212020; 26.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000104413; -.
DR iPTMnet; Q9CZ83; -.
DR PhosphoSitePlus; Q9CZ83; -.
DR EPD; Q9CZ83; -.
DR MaxQB; Q9CZ83; -.
DR PaxDb; Q9CZ83; -.
DR PeptideAtlas; Q9CZ83; -.
DR PRIDE; Q9CZ83; -.
DR ProteomicsDB; 260983; -. [Q9CZ83-1]
DR ProteomicsDB; 260984; -. [Q9CZ83-2]
DR Antibodypedia; 34660; 82 antibodies from 19 providers.
DR Ensembl; ENSMUST00000045697; ENSMUSP00000048814; ENSMUSG00000036860. [Q9CZ83-1]
DR Ensembl; ENSMUST00000108784; ENSMUSP00000104412; ENSMUSG00000036860. [Q9CZ83-2]
DR Ensembl; ENSMUST00000108785; ENSMUSP00000104413; ENSMUSG00000036860. [Q9CZ83-1]
DR Ensembl; ENSMUST00000108786; ENSMUSP00000104414; ENSMUSG00000036860. [Q9CZ83-2]
DR Ensembl; ENSMUST00000108787; ENSMUSP00000104415; ENSMUSG00000036860. [Q9CZ83-2]
DR GeneID; 67212; -.
DR KEGG; mmu:67212; -.
DR UCSC; uc007jdi.2; mouse. [Q9CZ83-1]
DR UCSC; uc007jdk.2; mouse. [Q9CZ83-2]
DR CTD; 128308; -.
DR MGI; MGI:1914462; Mrpl55.
DR VEuPathDB; HostDB:ENSMUSG00000036860; -.
DR eggNOG; KOG4616; Eukaryota.
DR GeneTree; ENSGT00390000010309; -.
DR HOGENOM; CLU_139855_0_0_1; -.
DR InParanoid; Q9CZ83; -.
DR OMA; NNAWRAS; -.
DR OrthoDB; 1553019at2759; -.
DR PhylomeDB; Q9CZ83; -.
DR TreeFam; TF320422; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 67212; 20 hits in 74 CRISPR screens.
DR ChiTaRS; Mrpl55; mouse.
DR PRO; PR:Q9CZ83; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CZ83; protein.
DR Bgee; ENSMUSG00000036860; Expressed in heart right ventricle and 226 other tissues.
DR Genevisible; Q9CZ83; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISS:UniProtKB.
DR Gene3D; 6.20.130.20; -; 1.
DR InterPro; IPR018615; Ribosomal_L55_mit.
DR InterPro; IPR044884; Ribosomal_L55_sf.
DR PANTHER; PTHR34095; PTHR34095; 1.
DR Pfam; PF09776; Mitoc_L55; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Mitochondrion; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..32
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 33..127
FT /note="39S ribosomal protein L55, mitochondrial"
FT /id="PRO_0000273100"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 7
FT /note="L -> LSACTSVR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022478"
FT CONFLICT 18
FT /note="A -> P (in Ref. 2; AAH28538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 127 AA; 15122 MW; A4ED7AA477DD0605 CRC64;
MPLAILLSLL RHCGVRAALP TPRHLHTSPW RADCSRASLT RLRRQAYARL YPVLLVKQDG
STIHIRYREP RRMLAMPLDL DALSPEERRA RFRKREAQLQ QKREEEPEVV DSFDTERYKQ
FWTKTKK
