RMC1_DICDI
ID RMC1_DICDI Reviewed; 978 AA.
AC Q54LC7;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Regulator of MON1-CCZ1 complex homolog;
DE AltName: Full=Mic1 domain-containing protein DDB_G0286707;
GN ORFNames=DDB_G0286707;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May have a role in autophagy. {ECO:0000250|UniProtKB:Q96DM3}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96DM3}.
CC Late endosome membrane {ECO:0000250|UniProtKB:Q96DM3}.
CC -!- SIMILARITY: Belongs to the RMC1 family. {ECO:0000305}.
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DR EMBL; AAFI02000089; EAL64109.1; -; Genomic_DNA.
DR RefSeq; XP_637634.1; XM_632542.1.
DR AlphaFoldDB; Q54LC7; -.
DR SMR; Q54LC7; -.
DR STRING; 44689.DDB0234052; -.
DR PaxDb; Q54LC7; -.
DR EnsemblProtists; EAL64109; EAL64109; DDB_G0286707.
DR GeneID; 8625775; -.
DR KEGG; ddi:DDB_G0286707; -.
DR dictyBase; DDB_G0286707; -.
DR eggNOG; KOG2377; Eukaryota.
DR HOGENOM; CLU_304106_0_0_1; -.
DR InParanoid; Q54LC7; -.
DR OMA; FNPIYEK; -.
DR PRO; PR:Q54LC7; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035658; C:Mon1-Ccz1 complex; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR InterPro; IPR040371; RMC1.
DR InterPro; IPR009755; RMC1_C.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12897; PTHR12897; 1.
DR Pfam; PF07035; Mic1; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Autophagy; Endosome; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..978
FT /note="Regulator of MON1-CCZ1 complex homolog"
FT /id="PRO_0000388259"
FT DOMAIN 735..908
FT /note="Mic1"
FT REGION 311..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 110802 MW; 60909624ECE838DC CRC64;
MSVEIVPLPL RINENESFLS YDDRLNRVVF KTSSGFGVVL LDDPEANRRY YSSDKPIIDA
KFSPDLKYSA IQFSDYDIEI LHLENGTRYI QTCKYKSSKA TILGYYWTTK ENILLVTNAS
LELYAMGLDG SCKLVKESKI KITNCVYSFN CNFGVLFLHS GGTSIQPYFF RTNSFDKLPK
FNIEGNGNGF NIKNLYVTKL HEKFFCVYGD QEYIYLYEMT LETIYKIKPI KILLSGPNSI
HFVDNLIIVH SELNISIVYD LKTIQRDRER GQTNKKEPEF PISAIPMTLS TINSNNLLYL
MNNATKTHST TSTPIINSIN NNNNNNNNPS SSSSPSSSNN SQSSSPTMIS SYEQRQIDQH
KEQQLQKPNV TLYSKNWRFI CPNYIFDPDS GIWYEVTLNF EKISNFLQFD SHKTIPFLQE
RTLLSAKFAL LSIIKTIIEF KTDTLDGIGK IYDDLNKVLF RTTNRQLTES LHKSINQPNN
NNNNNNNNNN NNNNNTAQTL NSTGNLSNSI SIGGMNTSTD NLTTTTTTSS SISSSPSNSF
IGNSKTNVNN LSYLNYKKQQ QQQMEKQQHM PNDDEDSFSL IGDGGSGGSG GSFYNTNTNT
TSTTNTTTSP SGKSNSNLKL SQSLNNTPNQ SPNSRSSLNN SSNNINNNNN NNNNNNNNNN
NNNHVVQNRQ SRSNQYILIN SHDMYDFVFN PIYEKLLIES QKEKEKENDN NNNNTNNNTN
NNNNNNIEEL NSNEKLELDS KYLIAVVIQY IKSLSFNHCT GISDKLYNLL ISLLIDNNMF
SRLHQFLQYY VITDSLSIAY KLLSIGEQYP PVLQLSLDMF KRLSMPNIII ETLLERGQVI
QAIRLLRSTK ETNEQAYQEL LTPTYPIQFL ASSSNQSNDT LFFSVFKFFE TNNLIIPSHP
SFDKYIKLFI EKFTEKSLSP LLLDILSNLN NNSTSGGDIT PKKNVGGSFL NQSLNNSSPT
LRSSNSLNSS PRLQYSNN
