ID   RMC1_MOUSE              Reviewed;         657 AA.
AC   Q8VC42; O35606;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Regulator of MON1-CCZ1 complex;
DE   AltName: Full=Colon cancer-associated protein Mic1;
DE            Short=Mic-1;
GN   Name=Rmc1; Synonyms=Mic1, Wdr98;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 353-657, AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=9211850; DOI=10.1126/science.277.5323.232;
RA   Loftus S.K., Morris J.A., Carstea E.D., Gu J.Z., Cummings C., Brown A.,
RA   Ellison J., Ohno K., Rosenfeld M.A., Tagle D.A., Pentchev P.G., Pavan W.J.;
RT   "Murine model of Niemann-Pick C disease: mutation in a cholesterol
RT   homeostasis gene.";
RL   Science 277:232-235(1997).
CC   -!- FUNCTION: Componement of the CCZ1-MON1 RAB7A guanine exchange factor
CC       (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary
CC       for endosomal/autophagic flux and efficient RAB7A localization.
CC       {ECO:0000250|UniProtKB:Q96DM3}.
CC   -!- SUBUNIT: Found in a complex with RMC1, CCZ1, MON1A and MON1B.
CC       {ECO:0000250|UniProtKB:Q96DM3}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96DM3}.
CC       Late endosome membrane {ECO:0000250|UniProtKB:Q96DM3}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart, brain, spleen, lung,
CC       liver, skeletal muscle, kidney and testis.
CC       {ECO:0000269|PubMed:9211850}.
CC   -!- SIMILARITY: Belongs to the RMC1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB63375.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC021846; AAH21846.1; -; mRNA.
DR   EMBL; AF003352; AAB63375.1; ALT_INIT; mRNA.
DR   CCDS; CCDS29063.1; -.
DR   RefSeq; NP_083899.1; NM_029623.2.
DR   AlphaFoldDB; Q8VC42; -.
DR   BioGRID; 218146; 10.
DR   IntAct; Q8VC42; 1.
DR   STRING; 10090.ENSMUSP00000025276; -.
DR   iPTMnet; Q8VC42; -.
DR   PhosphoSitePlus; Q8VC42; -.
DR   EPD; Q8VC42; -.
DR   MaxQB; Q8VC42; -.
DR   PaxDb; Q8VC42; -.
DR   PRIDE; Q8VC42; -.
DR   ProteomicsDB; 300408; -.
DR   Antibodypedia; 22041; 212 antibodies from 32 providers.
DR   DNASU; 76482; -.
DR   Ensembl; ENSMUST00000025276; ENSMUSP00000025276; ENSMUSG00000024410.
DR   GeneID; 76482; -.
DR   KEGG; mmu:76482; -.
DR   UCSC; uc008eca.1; mouse.
DR   CTD; 29919; -.
DR   MGI; MGI:1916528; Rmc1.
DR   VEuPathDB; HostDB:ENSMUSG00000024410; -.
DR   eggNOG; KOG2377; Eukaryota.
DR   GeneTree; ENSGT00390000009127; -.
DR   HOGENOM; CLU_022842_0_1_1; -.
DR   InParanoid; Q8VC42; -.
DR   OMA; VWVHNRE; -.
DR   OrthoDB; 440148at2759; -.
DR   PhylomeDB; Q8VC42; -.
DR   TreeFam; TF105850; -.
DR   BioGRID-ORCS; 76482; 6 hits in 73 CRISPR screens.
DR   ChiTaRS; Rmc1; mouse.
DR   PRO; PR:Q8VC42; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q8VC42; protein.
DR   Bgee; ENSMUSG00000024410; Expressed in granulocyte and 237 other tissues.
DR   ExpressionAtlas; Q8VC42; baseline and differential.
DR   Genevisible; Q8VC42; MM.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR040371; RMC1.
DR   InterPro; IPR009755; RMC1_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12897; PTHR12897; 1.
DR   Pfam; PF07035; Mic1; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endosome; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..657
FT                   /note="Regulator of MON1-CCZ1 complex"
FT                   /id="PRO_0000096482"
FT   DOMAIN          471..637
FT                   /note="Mic1"
SQ   SEQUENCE   657 AA;  74922 MW;  2F37B8288BD8E1FA CRC64;
     MGGEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG PDDRNPISFR
     MDDRGEVKCI KFSLENKILA VQRTAKAVDF CNFIPDNSQL EYTQECKTKN ANILGFCWTS
     STEIVFITDQ GIEFYQVMPE KRSLKLLKSH NINVNWYTYC PESAVILLST TVLENVLQPF
     HFRAGTMSKL PKFEIELPAA PKSTKLSLSE RDIAMATIYG QLYILFLRHH SRTSNSTGAE
     VVLYHLPREG ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI RLRGEFDGTV
     TFHHPVLPAR SIQPYEIPLA GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS ASQGYLWNLQ
     VKLQPIVNLL PDKGRLMDFL LQRKECKAVV LSVCSQMLSE SDRATLPVIA TVFDKLNHEY
     KKYLDADQSY TMAVEAGQSR SNPPLKRPVR TQAVVDQSDV YTQVLSPFVE NKEMPHKFVI
     AVLMEYIRSL NQFQIPVQHY LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL
     ESFYPPAHQL SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
     RQTDDVMLFY TIFRFFEQRN QRLRGNPNFT PGEHCEEHVA FFKQVFGEQA LMRPTTF