RMD1_CAEEL
ID RMD1_CAEEL Reviewed; 226 AA.
AC P34560; H2FLF5; H2FLF6;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Regulator of microtubule dynamics protein 1;
GN Name=rmd-1; ORFNames=T05G5.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, INTERACTION WITH AIR-2, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=18070910; DOI=10.1083/jcb.200705108;
RA Oishi K., Okano H., Sawa H.;
RT "RMD-1, a novel microtubule-associated protein, functions in chromosome
RT segregation in Caenorhabditis elegans.";
RL J. Cell Biol. 179:1149-1162(2007).
CC -!- FUNCTION: Acts in chromosome segregation and organization during
CC mitosis. {ECO:0000269|PubMed:18070910}.
CC -!- SUBUNIT: Interacts with air-2. {ECO:0000269|PubMed:18070910}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000269|PubMed:18070910}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34560-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34560-2; Sequence=VSP_044212;
CC -!- DEVELOPMENTAL STAGE: Detected during metaphase and anaphase.
CC {ECO:0000269|PubMed:18070910}.
CC -!- DISRUPTION PHENOTYPE: Defects in cytokinesis, spindle orientation,
CC chromosome segregation, osmotic regulation and merotelic attachments of
CC microtubules to chromosomes. {ECO:0000269|PubMed:18070910}.
CC -!- SIMILARITY: Belongs to the FAM82/RMD family. {ECO:0000305}.
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DR EMBL; Z27079; CCF23359.1; -; Genomic_DNA.
DR EMBL; Z27079; CCF23360.1; -; Genomic_DNA.
DR PIR; S41007; S41007.
DR RefSeq; NP_001255029.1; NM_001268100.1. [P34560-1]
DR RefSeq; NP_001255030.1; NM_001268101.1. [P34560-2]
DR AlphaFoldDB; P34560; -.
DR SMR; P34560; -.
DR BioGRID; 41574; 15.
DR STRING; 6239.T05G5.7a; -.
DR EPD; P34560; -.
DR PaxDb; P34560; -.
DR PeptideAtlas; P34560; -.
DR EnsemblMetazoa; T05G5.7a.1; T05G5.7a.1; WBGene00011501. [P34560-1]
DR EnsemblMetazoa; T05G5.7b.1; T05G5.7b.1; WBGene00011501. [P34560-2]
DR GeneID; 176379; -.
DR KEGG; cel:CELE_T05G5.7; -.
DR CTD; 176379; -.
DR WormBase; T05G5.7a; CE46837; WBGene00011501; rmd-1. [P34560-1]
DR WormBase; T05G5.7b; CE46893; WBGene00011501; rmd-1. [P34560-2]
DR eggNOG; ENOG502QS2U; Eukaryota.
DR GeneTree; ENSGT00950000182992; -.
DR InParanoid; P34560; -.
DR OMA; QFVTECK; -.
DR OrthoDB; 1380644at2759; -.
DR PhylomeDB; P34560; -.
DR PRO; PR:P34560; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00011501; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0097431; C:mitotic spindle pole; IDA:WormBase.
DR GO; GO:0005876; C:spindle microtubule; IDA:WormBase.
DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IMP:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007052; P:mitotic spindle organization; IMP:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Chromosome partition;
KW Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Reference proteome.
FT CHAIN 1..226
FT /note="Regulator of microtubule dynamics protein 1"
FT /id="PRO_0000065446"
FT VAR_SEQ 1..31
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_044212"
SQ SEQUENCE 226 AA; 25893 MW; 92C398F603A8AA80 CRC64;
MESFATSDKL FESREFVKGL EELKKRREDG EMTCDLLWRM CRFCHELSTT MSGEQRRKML
IEGRDYGLEA MDLDPSSFLA AKWTAIMFGL VVDQLPTKEK INDGGRLKDM LDKALELDPT
DFALLHLRAR FSYTIANLSW LERKAASMLY SEVPKATIDD ALVDFKAAYN QNADWIENLL
FLSKCHLAKK EKQQAREMLN KAIVLPAASS NDAQFVTECK SLLQKC
