RMD1_HUMAN
ID RMD1_HUMAN Reviewed; 314 AA.
AC Q96DB5; A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; Q9Y398;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Regulator of microtubule dynamics protein 1;
DE Short=RMD-1;
DE Short=hRMD-1;
DE AltName: Full=Protein FAM82B;
GN Name=RMDN1; Synonyms=FAM82B; ORFNames=CGI-90;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-52.
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP ASN-52.
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, INTERACTION WITH MICROTUBULES, AND SUBCELLULAR LOCATION.
RX PubMed=18070910; DOI=10.1083/jcb.200705108;
RA Oishi K., Okano H., Sawa H.;
RT "RMD-1, a novel microtubule-associated protein, functions in chromosome
RT segregation in Caenorhabditis elegans.";
RL J. Cell Biol. 179:1149-1162(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000269|PubMed:18070910}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18070910}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}.
CC Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}.
CC Note=In interphase localizes in the cytoplasm, and during mitosis
CC localizes to the spindle microtubules and spindle poles.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96DB5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96DB5-2; Sequence=VSP_054647;
CC Name=3;
CC IsoId=Q96DB5-3; Sequence=VSP_054647, VSP_055727;
CC -!- SIMILARITY: Belongs to the RMDN family. {ECO:0000305}.
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DR EMBL; AF151848; AAD34085.1; -; mRNA.
DR EMBL; AK297896; BAG60217.1; -; mRNA.
DR EMBL; AK303122; BAG64228.1; -; mRNA.
DR EMBL; AC103817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009671; AAH09671.1; -; mRNA.
DR EMBL; BR000690; FAA00415.1; -; mRNA.
DR CCDS; CCDS34918.1; -. [Q96DB5-1]
DR CCDS; CCDS69509.1; -. [Q96DB5-3]
DR CCDS; CCDS69510.1; -. [Q96DB5-2]
DR RefSeq; NP_001273636.1; NM_001286707.1. [Q96DB5-3]
DR RefSeq; NP_001273648.1; NM_001286719.1. [Q96DB5-2]
DR RefSeq; NP_001304736.1; NM_001317807.1.
DR RefSeq; NP_057117.2; NM_016033.2. [Q96DB5-1]
DR AlphaFoldDB; Q96DB5; -.
DR SMR; Q96DB5; -.
DR BioGRID; 119303; 48.
DR IntAct; Q96DB5; 10.
DR MINT; Q96DB5; -.
DR STRING; 9606.ENSP00000385927; -.
DR GlyGen; Q96DB5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96DB5; -.
DR PhosphoSitePlus; Q96DB5; -.
DR SwissPalm; Q96DB5; -.
DR BioMuta; RMDN1; -.
DR EPD; Q96DB5; -.
DR jPOST; Q96DB5; -.
DR MassIVE; Q96DB5; -.
DR MaxQB; Q96DB5; -.
DR PaxDb; Q96DB5; -.
DR PeptideAtlas; Q96DB5; -.
DR PRIDE; Q96DB5; -.
DR ProteomicsDB; 18645; -.
DR ProteomicsDB; 5630; -.
DR ProteomicsDB; 76269; -. [Q96DB5-1]
DR TopDownProteomics; Q96DB5-1; -. [Q96DB5-1]
DR Antibodypedia; 12639; 139 antibodies from 19 providers.
DR DNASU; 51115; -.
DR Ensembl; ENST00000406452.8; ENSP00000385927.3; ENSG00000176623.12. [Q96DB5-1]
DR Ensembl; ENST00000430676.6; ENSP00000409661.2; ENSG00000176623.12. [Q96DB5-2]
DR Ensembl; ENST00000519966.5; ENSP00000428661.1; ENSG00000176623.12. [Q96DB5-3]
DR GeneID; 51115; -.
DR KEGG; hsa:51115; -.
DR MANE-Select; ENST00000406452.8; ENSP00000385927.3; NM_016033.3; NP_057117.2.
DR UCSC; uc003ydu.4; human. [Q96DB5-1]
DR CTD; 51115; -.
DR DisGeNET; 51115; -.
DR GeneCards; RMDN1; -.
DR HGNC; HGNC:24285; RMDN1.
DR HPA; ENSG00000176623; Low tissue specificity.
DR MIM; 611871; gene.
DR neXtProt; NX_Q96DB5; -.
DR OpenTargets; ENSG00000176623; -.
DR PharmGKB; PA142671849; -.
DR VEuPathDB; HostDB:ENSG00000176623; -.
DR eggNOG; ENOG502QSJV; Eukaryota.
DR GeneTree; ENSGT00950000182992; -.
DR InParanoid; Q96DB5; -.
DR OMA; KDVEILW; -.
DR OrthoDB; 1380644at2759; -.
DR PhylomeDB; Q96DB5; -.
DR TreeFam; TF315854; -.
DR PathwayCommons; Q96DB5; -.
DR SignaLink; Q96DB5; -.
DR BioGRID-ORCS; 51115; 6 hits in 1075 CRISPR screens.
DR ChiTaRS; RMDN1; human.
DR GenomeRNAi; 51115; -.
DR Pharos; Q96DB5; Tdark.
DR PRO; PR:Q96DB5; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96DB5; protein.
DR Bgee; ENSG00000176623; Expressed in calcaneal tendon and 193 other tissues.
DR ExpressionAtlas; Q96DB5; baseline and differential.
DR Genevisible; Q96DB5; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097431; C:mitotic spindle pole; IDA:UniProtKB.
DR GO; GO:0005876; C:spindle microtubule; IDA:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..314
FT /note="Regulator of microtubule dynamics protein 1"
FT /id="PRO_0000187181"
FT REPEAT 168..204
FT /note="TPR 1"
FT REPEAT 222..258
FT /note="TPR 2"
FT MOD_RES 165
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9DCV4"
FT VAR_SEQ 166..195
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054647"
FT VAR_SEQ 254..266
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055727"
FT VARIANT 52
FT /note="K -> N (in dbSNP:rs6980476)"
FT /evidence="ECO:0000269|PubMed:10810093,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_049028"
FT CONFLICT 27
FT /note="T -> P (in Ref. 1; AAD34085)"
FT /evidence="ECO:0000305"
FT CONFLICT 33..37
FT /note="HCGPC -> IAAPA (in Ref. 1; AAD34085)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35808 MW; 4976011FFDF3C389 CRC64;
MALAARLWRL LPFRRGAAPG SRLPAGTSGS RGHCGPCRFR GFEVMGNPGT FKRGLLLSAL
SYLGFETYQV ISQAAVVHAT AKVEEILEQA DYLYESGETE KLYQLLTQYK ESEDAELLWR
LARASRDVAQ LSRTSEEEKK LLVYEALEYA KRALEKNESS FASHKWYAIC LSDVGDYEGI
KAKIANAYII KEHFEKAIEL NPKDATSIHL MGIWCYTFAE MPWYQRRIAK MLFATPPSST
YEKALGYFHR AEQVDPNFYS KNLLLLGKTY LKLHNKKLAA FWLMKAKDYP AHTEEDKQIQ
TEAAQLLTSF SEKN
