RMD1_MOUSE
ID RMD1_MOUSE Reviewed; 305 AA.
AC Q9DCV4; A2AGJ3; A9UN01; Q8C0Y9; Q8R166; Q9CWS6;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Regulator of microtubule dynamics protein 1;
DE Short=RMD-1;
DE Short=mRMD-1;
DE AltName: Full=Microtubule-associated protein;
DE AltName: Full=Protein FAM82B;
GN Name=Rmdn1; Synonyms=Fam82b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary gland, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=18070910; DOI=10.1083/jcb.200705108;
RA Oishi K., Okano H., Sawa H.;
RT "RMD-1, a novel microtubule-associated protein, functions in chromosome
RT segregation in Caenorhabditis elegans.";
RL J. Cell Biol. 179:1149-1162(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-160 AND LYS-245, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250}. Note=In interphase localizes in the cytoplasm, and
CC during mitosis localizes to the spindle microtubules and spindle poles.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RMDN family. {ECO:0000305}.
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DR EMBL; AK002442; BAB22104.1; -; mRNA.
DR EMBL; AK010421; BAB26924.2; -; mRNA.
DR EMBL; AK029446; BAC26453.1; -; mRNA.
DR EMBL; AL683894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025158; AAH25158.1; -; mRNA.
DR EMBL; BC096046; AAH96046.1; -; mRNA.
DR EMBL; BR000693; FAA00418.1; -; mRNA.
DR CCDS; CCDS17992.1; -.
DR RefSeq; NP_079752.3; NM_025476.6.
DR AlphaFoldDB; Q9DCV4; -.
DR SMR; Q9DCV4; -.
DR STRING; 10090.ENSMUSP00000029888; -.
DR iPTMnet; Q9DCV4; -.
DR PhosphoSitePlus; Q9DCV4; -.
DR SwissPalm; Q9DCV4; -.
DR EPD; Q9DCV4; -.
DR jPOST; Q9DCV4; -.
DR MaxQB; Q9DCV4; -.
DR PaxDb; Q9DCV4; -.
DR PeptideAtlas; Q9DCV4; -.
DR PRIDE; Q9DCV4; -.
DR ProteomicsDB; 299834; -.
DR Antibodypedia; 12639; 139 antibodies from 19 providers.
DR DNASU; 66302; -.
DR Ensembl; ENSMUST00000029888; ENSMUSP00000029888; ENSMUSG00000028229.
DR GeneID; 66302; -.
DR KEGG; mmu:66302; -.
DR UCSC; uc008sca.3; mouse.
DR CTD; 51115; -.
DR MGI; MGI:1913552; Rmdn1.
DR VEuPathDB; HostDB:ENSMUSG00000028229; -.
DR eggNOG; ENOG502QSJV; Eukaryota.
DR GeneTree; ENSGT00950000182992; -.
DR HOGENOM; CLU_046369_1_1_1; -.
DR InParanoid; Q9DCV4; -.
DR OMA; KDVEILW; -.
DR OrthoDB; 1380644at2759; -.
DR PhylomeDB; Q9DCV4; -.
DR TreeFam; TF315854; -.
DR BioGRID-ORCS; 66302; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9DCV4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9DCV4; protein.
DR Bgee; ENSMUSG00000028229; Expressed in interventricular septum and 238 other tissues.
DR ExpressionAtlas; Q9DCV4; baseline and differential.
DR Genevisible; Q9DCV4; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0097431; C:mitotic spindle pole; ISO:MGI.
DR GO; GO:0005876; C:spindle microtubule; ISO:MGI.
DR GO; GO:0008017; F:microtubule binding; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..305
FT /note="Regulator of microtubule dynamics protein 1"
FT /id="PRO_0000187183"
FT REPEAT 163..199
FT /note="TPR 1"
FT REPEAT 217..253
FT /note="TPR 2"
FT MOD_RES 160
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 245
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 24
FT /note="G -> S (in Ref. 2; AAH25158/AAH96046)"
FT /evidence="ECO:0000305"
FT CONFLICT 31
FT /note="A -> R (in Ref. 1; BAB26924)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="W -> R (in Ref. 1; BAB22104)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="K -> R (in Ref. 1; BAB22104)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 35000 MW; 692F349733A5FA8D CRC64;
MALSSRLWRR LPPLRVCQQT RTWGSRGRCG AWGVRACEVI GNTRPFKRGF LFSALSYLGF
ETYQIISQAA VVHATAKVEE ILAQADYLYE SGETEKLYQL LIQYKESEDG ELLWRLARAS
RDIAQLSKTS EEEKKVLVYE ALDYAKRALE KKESSSAAHK WYAICISDVG DYEGIKVKIA
NAYVIKEHFE KAIELNPKDA TSIHLMGIWC YTFAEMPWYQ RRIAKVLFAN PPSSTYEEAL
RYFHKAEEVD PNFYSKNLLL LGKTYLKLNN KKLAAFWLVK AKGYPAHTEE DKQIQTEAAQ
LLTGL
