ID   RMD1_RAT                Reviewed;         310 AA.
AC   Q4G069;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Regulator of microtubule dynamics protein 1;
DE            Short=RMD-1;
DE   AltName: Full=Protein FAM82B;
GN   Name=Rmdn1; Synonyms=Fam82b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}. Note=In interphase localizes in the cytoplasm, and
CC       during mitosis localizes to the spindle microtubules and spindle poles.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RMDN family. {ECO:0000305}.
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DR   EMBL; BC098713; AAH98713.1; -; mRNA.
DR   RefSeq; NP_001026833.1; NM_001031663.1.
DR   AlphaFoldDB; Q4G069; -.
DR   SMR; Q4G069; -.
DR   BioGRID; 271727; 1.
DR   STRING; 10116.ENSRNOP00000030229; -.
DR   iPTMnet; Q4G069; -.
DR   PhosphoSitePlus; Q4G069; -.
DR   jPOST; Q4G069; -.
DR   PaxDb; Q4G069; -.
DR   PRIDE; Q4G069; -.
DR   Ensembl; ENSRNOT00000036050; ENSRNOP00000030229; ENSRNOG00000025145.
DR   GeneID; 500419; -.
DR   KEGG; rno:500419; -.
DR   UCSC; RGD:1563085; rat.
DR   CTD; 51115; -.
DR   RGD; 1563085; Rmdn1.
DR   eggNOG; ENOG502QSJV; Eukaryota.
DR   GeneTree; ENSGT00950000182992; -.
DR   HOGENOM; CLU_046369_1_1_1; -.
DR   InParanoid; Q4G069; -.
DR   OrthoDB; 1380644at2759; -.
DR   PhylomeDB; Q4G069; -.
DR   TreeFam; TF315854; -.
DR   PRO; PR:Q4G069; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000025145; Expressed in heart and 19 other tissues.
DR   ExpressionAtlas; Q4G069; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097431; C:mitotic spindle pole; ISO:RGD.
DR   GO; GO:0005876; C:spindle microtubule; ISO:RGD.
DR   GO; GO:0008017; F:microtubule binding; ISO:RGD.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW   TPR repeat.
FT   CHAIN           1..310
FT                   /note="Regulator of microtubule dynamics protein 1"
FT                   /id="PRO_0000346795"
FT   REPEAT          168..204
FT                   /note="TPR 1"
FT   REPEAT          222..258
FT                   /note="TPR 2"
FT   MOD_RES         165
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DCV4"
SQ   SEQUENCE   310 AA;  35401 MW;  698B25285FE00C4C CRC64;
     MALSSRLWRL LPLLRGAEQS VCQLARSWGS GGRCGTWGFR GSEVTGNTRA FKRGLLFSAL
     SYLGFETYQV ISQAAVVHAT AKVEEILEQA DYLYESGETE KLYQLLTQYK ESEDVELLWR
     LARASRDIAQ LCKTSEEEKK VLLYEALEYA KRALEKKGSS FAAHKWYAIC ISDVGDYEGI
     KVKIANAYVI KEHFEKAIEL NPKDATSIHL MGIWCYTFAE MPWYQRRIAE VLFANPPSST
     YEEALKYFHR AEEVDPNFYS KNLLLLGKTY LKLNNKKLAA FWLVKAKSYP AHTEEDKQIQ
     TEAAQLLTGL