RMD1_YEAST
ID RMD1_YEAST Reviewed; 430 AA.
AC Q03441; D6VRY7; Q05210;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Sporulation protein RMD1;
DE AltName: Full=Required for meiotic nuclear division protein 1;
GN Name=RMD1; OrderedLocusNames=YDL001W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 281-430.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=3537685; DOI=10.1128/mcb.6.1.241-245.1986;
RA Mann C., Davis R.W.;
RT "Structure and sequence of the centromeric DNA of chromosome 4 in
RT Saccharomyces cerevisiae.";
RL Mol. Cell. Biol. 6:241-245(1986).
RN [4]
RP SEQUENCE REVISION.
RA Sapolsky R.;
RL Submitted (JUN-1987) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RX PubMed=12586695; DOI=10.1093/genetics/163.1.47;
RA Enyenihi A.H., Saunders W.S.;
RT "Large-scale functional genomic analysis of sporulation and meiosis in
RT Saccharomyces cerevisiae.";
RL Genetics 163:47-54(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Required for sporulation where it is believed to have a role
CC in meiotic nuclear division. {ECO:0000269|PubMed:12586695}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 952 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RMD1/sif2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA66895.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Z48008; CAA88060.1; -; Genomic_DNA.
DR EMBL; M13000; AAA66895.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006938; DAA11847.1; -; Genomic_DNA.
DR PIR; S50981; S50981.
DR RefSeq; NP_010283.3; NM_001180060.3.
DR AlphaFoldDB; Q03441; -.
DR BioGRID; 32053; 153.
DR DIP; DIP-857N; -.
DR IntAct; Q03441; 4.
DR MINT; Q03441; -.
DR STRING; 4932.YDL001W; -.
DR iPTMnet; Q03441; -.
DR MaxQB; Q03441; -.
DR PaxDb; Q03441; -.
DR PRIDE; Q03441; -.
DR EnsemblFungi; YDL001W_mRNA; YDL001W; YDL001W.
DR GeneID; 851563; -.
DR KEGG; sce:YDL001W; -.
DR SGD; S000002159; RMD1.
DR VEuPathDB; FungiDB:YDL001W; -.
DR eggNOG; KOG2861; Eukaryota.
DR GeneTree; ENSGT00390000013337; -.
DR HOGENOM; CLU_011220_1_2_1; -.
DR InParanoid; Q03441; -.
DR OMA; VYSQVNR; -.
DR BioCyc; YEAST:G3O-29432-MON; -.
DR PRO; PR:Q03441; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03441; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR003734; DUF155.
DR Pfam; PF02582; DUF155; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Reference proteome; Sporulation.
FT CHAIN 1..430
FT /note="Sporulation protein RMD1"
FT /id="PRO_0000097360"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 49932 MW; 880CFCAAE220D467 CRC64;
MVDSNDDQPE RHALLHNDIQ TSNNSRPSLV QKKYLPTPQD TRKSRASYTG SAMINPTSKQ
SRTGSGAQRT SRTAQKLKLL PEEPFQRDSE RLTDLKNQEV YSQVNRIKDK PARRDAEKLG
KAHRHLLPRS TAYCTASSYN MKELVRWLKD CRKLHHTHPK LFDECLYTPF IYNDWRGDKR
FEDEDVIRLD DEGGEIIVSD KHPDLFIFEY GVVVMWGFTE REEKAFLNDI EKFEKEKLAE
EDIQVEEFNY YVTKSYQPRI YNDFITLRDG SNYMVKLSIS HAIAQSVKIS LFEELVDNTI
EDTQDIPQEI AYSGKVSMSK EDIMKSIGEL FILRININLH GSVLDSPEIM WSEPQLEPIY
QATRGYLEIN QRVSLLNQRL EVISDLLQML KEQLGHSHEE YLEFIVILLV GVEVLISVIN
IVVDMLASQH
