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RME1_YEAST
ID   RME1_YEAST              Reviewed;         300 AA.
AC   P32338; D6VUI2; Q45TA6;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 163.
DE   RecName: Full=Zinc finger protein RME1;
GN   Name=RME1; OrderedLocusNames=YGR044C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1936989; DOI=10.1101/gad.5.11.1982;
RA   Covitz P.A., Herskowitz I., Mitchell A.P.;
RT   "The yeast RME1 gene encodes a putative zinc finger protein that is
RT   directly repressed by a1-alpha 2.";
RL   Genes Dev. 5:1982-1989(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 200060 / W303, ATCC 204508 / S288c,
RC   ATCC 204626 / S288c / A364A, ATCC 24657 / D273-10B, YJM 145, YJM 269, and
RC   YJM 270;
RA   Deutschbauer A.M., Davis R.W.;
RT   "Molecular genetic dissection of a quantitative trait in yeast.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   FUNCTION.
RX   PubMed=8339935; DOI=10.1101/gad.7.8.1598;
RA   Covitz P.A., Mitchell A.P.;
RT   "Repression by the yeast meiotic inhibitor RME1.";
RL   Genes Dev. 7:1598-1608(1993).
RN   [6]
RP   FUNCTION.
RX   PubMed=8846775; DOI=10.1002/j.1460-2075.1995.tb00270.x;
RA   Toone W.M., Johnson A.L., Banks G.R., Toyn J.H., Stuart D., Wittenberg C.,
RA   Johnston L.H.;
RT   "Rme1, a negative regulator of meiosis, is also a positive activator of G1
RT   cyclin gene expression.";
RL   EMBO J. 14:5824-5832(1995).
CC   -!- FUNCTION: Involved in the control of meiosis. Represses the
CC       transcription of the IME1 gene thereby inhibiting cells from entering
CC       meiosis. But also activates the CLN2 gene thus promoting mitosis.
CC       {ECO:0000269|PubMed:8339935, ECO:0000269|PubMed:8846775}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; M76447; AAA35238.1; -; Genomic_DNA.
DR   EMBL; DQ116799; AAZ29879.1; -; Genomic_DNA.
DR   EMBL; DQ116801; AAZ29881.1; -; Genomic_DNA.
DR   EMBL; DQ116802; AAZ29882.1; -; Genomic_DNA.
DR   EMBL; DQ116804; AAZ29884.1; -; Genomic_DNA.
DR   EMBL; DQ116805; AAZ29885.1; -; Genomic_DNA.
DR   EMBL; DQ116806; AAZ29886.1; -; Genomic_DNA.
DR   EMBL; DQ116807; AAZ29887.1; -; Genomic_DNA.
DR   EMBL; Z72829; CAA97043.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08143.1; -; Genomic_DNA.
DR   PIR; A41517; A41517.
DR   RefSeq; NP_011558.1; NM_001181173.1.
DR   AlphaFoldDB; P32338; -.
DR   BioGRID; 33291; 162.
DR   STRING; 4932.YGR044C; -.
DR   iPTMnet; P32338; -.
DR   MaxQB; P32338; -.
DR   PaxDb; P32338; -.
DR   PRIDE; P32338; -.
DR   EnsemblFungi; YGR044C_mRNA; YGR044C; YGR044C.
DR   GeneID; 852935; -.
DR   KEGG; sce:YGR044C; -.
DR   SGD; S000003276; RME1.
DR   VEuPathDB; FungiDB:YGR044C; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_943837_0_0_1; -.
DR   InParanoid; P32338; -.
DR   OMA; IADSTYC; -.
DR   BioCyc; YEAST:G3O-30763-MON; -.
DR   PRO; PR:P32338; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P32338; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IMP:SGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045835; P:negative regulation of meiotic nuclear division; IMP:SGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:SGD.
DR   GO; GO:0051038; P:negative regulation of transcription involved in meiotic cell cycle; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR   GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IDA:SGD.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   1: Evidence at protein level;
KW   Activator; Cell cycle; Cell division; DNA-binding; Meiosis; Metal-binding;
KW   Mitosis; Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..300
FT                   /note="Zinc finger protein RME1"
FT                   /id="PRO_0000046848"
FT   ZN_FING         178..199
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         206..234
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         256..281
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          80..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         183
FT                   /note="C->S: Inactivates RME1."
FT   MUTAGEN         213
FT                   /note="C->S: Inactivates RME1."
FT   MUTAGEN         263
FT                   /note="C->S: Inactivates RME1."
SQ   SEQUENCE   300 AA;  33904 MW;  CB4CEE2474A21104 CRC64;
     MSPCYGQNSA IAKGSWNREV LQEVQPIYHW HDFGQNMKEY SASPLEGDSS LPSSLPSSTE
     DCLLLSLENT ITVIAGNQRQ AYDSTSSTEE GTAPQLRPDE IADSTHCITS LVDPEFRDLI
     NYGRQKGANP VFIESNTTEQ SHSQCILGYP QKSHVAQLYH DPKVLSTISE GQTKRGSYHC
     SHCSEKFATL VEFAAHLDEF NLERPCKCPI EQCPWKILGF QQATGLRRHC ASQHIGELDI
     EMEKSLNLKV EKYPGLNCPF PICQKTFRRK DAYKRHVAMV HNNADSRFNK RLKKILNNTK
 
 
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