RME6_DROPS
ID RME6_DROPS Reviewed; 1774 AA.
AC Q29HW3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Receptor-mediated endocytosis protein 6 homolog;
GN ORFNames=GA14078;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Acts both as a GTPase-activating protein (GAP) and a guanine
CC nucleotide exchange factor (GEF), and participates in endocytosis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family. {ECO:0000305}.
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DR EMBL; CH379064; EAL31644.2; -; Genomic_DNA.
DR RefSeq; XP_001354590.2; XM_001354554.3.
DR AlphaFoldDB; Q29HW3; -.
DR SMR; Q29HW3; -.
DR STRING; 7237.FBpp0285879; -.
DR EnsemblMetazoa; FBtr0287441; FBpp0285879; FBgn0074109.
DR GeneID; 4814905; -.
DR KEGG; dpo:Dpse_GA14078; -.
DR eggNOG; KOG2319; Eukaryota.
DR HOGENOM; CLU_002165_1_0_1; -.
DR InParanoid; Q29HW3; -.
DR OMA; SCFLGKK; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0074109; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR GO; GO:0051223; P:regulation of protein transport; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.506.10; -; 1.
DR Gene3D; 1.20.1050.80; -; 1.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; PTHR23101; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF109993; SSF109993; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endocytosis; GTPase activation;
KW Guanine-nucleotide releasing factor; Membrane; Reference proteome.
FT CHAIN 1..1774
FT /note="Receptor-mediated endocytosis protein 6 homolog"
FT /id="PRO_0000324777"
FT DOMAIN 141..366
FT /note="Ras-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00167"
FT DOMAIN 1635..1774
FT /note="VPS9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00550"
FT REGION 444..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1516..1546
FT /evidence="ECO:0000255"
FT COMPBIAS 518..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..918
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1079
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1774 AA; 197267 MW; 9FA4F1CCADD365AA CRC64;
MEPTAAGNLL EIMDLARTLR QEQLFIQQEQ TAFGQLTGAL ETNAGTITKL AFVCAQQRQI
LNELLVARND HDPLLSCRRA SAYDSAQFMD AKQVLPYEHA LAYEDLFNYL YNTPYLLALS
LATADRLSLL SSGQLGQIIN TIATGLYGNA INTKDVELLL KLLRELIEIQ LLGSEQPRRL
LRTNSSSFAR LYQRLVESLF SARIFLTAAL HAPLMGVLSE HDVWLDLDPH KLMQSFSQKE
RERRFGQAGE GEHGEEYQRN VARFHAETLG KLHTHAQVFV KSLQQSWALF PSSLRWLLQT
LSQQLRQTHR HKEQEIRQLL TDLVFTHFIS PAIVSADLVG IIDVNVSERM RHNLNQIVQL
LQRLALNDEG SELVQLMELL MVGETGEDVV AILPQQTDFE RSQLAINQRE LSQFVEFFRL
LTSRDEYDVS AEERQRLQRI LGRIPKQQQQ QQSQSELPDA TANSPEKQQN NNNKKNNNRS
LMRLGKAKKK LANSMSFSNS NSNSNKNLQP AVEQLPPLAN GQANSSNISS ASNGDLEQCS
SHSGSNTSLS SCGAAPAAPT PAPTAVTNDH QYCARDEPVL MFSIYNASAK SKLKPLTEEE
VLKMNCIGQD GSNLLPAVAC TTGVVAPSSN NDDVSSLEAM RRPQDDASIG NSDNLEAISE
AAHSVASSLD LEEQQERDVH ENEDNLSDMV SANVSGRGTP NISGRDTPSS QVTDGDGGGG
DMAHHHGHHV RAANPQMQKM LLSKARSDID DKFCKFELKK FEVDENVSII SDTWSTDVLA
SDSENTLDAT GSERGGDRGD RGDRDRDRNF STPLIPSAVV LPGDNNFVVE ALARAGAGVI
SGPHMDASDQ RSESNWSTDV LASDSEKLAE IDTDDNASIT AKSDIGPGSG GGAGVPEAGG
GGGVVGDDDD EDEQTPGSSG DGEPDPDPDP DRERLRNGSE RSQEDSAFFD AVNSYEDAHH
LYHGASSLAR SSVRTSYHVM GGESSFQQQY KSSGAEGIGR KTTPLMGTSC MRRQTSAESS
ISNQSLNLEE PPPPPRALAK HHHHHQHRDR DRDRDRDRDH REHHHKSAAL KKKKHQEHKE
HQHRDLIDFS DCSEDKDEEE QPPGLVQQLL DMFNQEEQQQ QQQQQGCSSQ SSVEHRRISM
EQRSQCIDGR RNGILAGSMR RHQSLNYENH EIMLNSMLPK TDDDKQELLL CAQTQQQLQL
EERAAAAENS CSNRAGAGAG AGARGTSKPP SKATGAIPKS ISFDASADKE QQPYRDRERE
RDRERDRERD RDRERDRDRD RDRDRDREHH SAGIFNKLKQ GFFKHRRGGS SSSKNNAIAI
AAPSSINPNP SPSSATDPGG RSVSFDPSAG VCVSFGTHYC DSSEDILAKY RRKVSSSSEA
TNSDSTGNGA GGGAAAAAAA AAAHLHKHVN GGLLPGVAFG SVKQKLRTVL SKTDLHSGDF
RQTTPMRPLD ATTPLQIYLQ IQLAQCISLQ RLPQISHVAE ALRCLEQLER PQHGQLLVEL
QHDLQRRQSY LQYLMRHRQQ LLLRSEQLEQ LEVRLRSEAR SCQRCLMQSL VRLYLAWARQ
QDKLEQFQTE FGQLRASDER VELVEEFVEQ LLQQLITSAD LLDDWQVDAA REAIERMLLE
LMYQQVMFPN EDADVSRDTV LSAHIGKLQR FVHPAHPALC IAQEYLGEAP WTFAQQQLCH
MAAYKTPREK LQCIINCISS IMSLLRMSCG RVPAADDLLP VLIYVVIMAN PPYLLSTVEY
ISCFLGRKLD GENEFYWTLF GSVVKFIKTM DYLD
