ID   RMI1_CHICK              Reviewed;         627 AA.
AC   Q5ZHV8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=RecQ-mediated genome instability protein 1;
GN   Name=RMI1; ORFNames=RCJMB04_32l8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Essential component of the RMI complex, a complex that plays
CC       an important role in the processing of homologous recombination
CC       intermediates to limit DNA crossover formation in cells. Promotes TOP3A
CC       binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-
CC       mediated dissolution. Required for BLM phosphorylation during mitosis.
CC       Within the BLM complex, required for BLM and TOP3A stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RMI complex, containing at least TOP3A, RMI1
CC       and RMI2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RMI1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ721026; CAG32685.1; -; mRNA.
DR   RefSeq; NP_001026783.1; NM_001031612.2.
DR   AlphaFoldDB; Q5ZHV8; -.
DR   SMR; Q5ZHV8; -.
DR   BioGRID; 688989; 1.
DR   STRING; 9031.ENSGALP00000020535; -.
DR   PaxDb; Q5ZHV8; -.
DR   GeneID; 431669; -.
DR   KEGG; gga:431669; -.
DR   CTD; 80010; -.
DR   VEuPathDB; HostDB:geneid_431669; -.
DR   eggNOG; KOG3683; Eukaryota.
DR   InParanoid; Q5ZHV8; -.
DR   OrthoDB; 531291at2759; -.
DR   PhylomeDB; Q5ZHV8; -.
DR   PRO; PR:Q5ZHV8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0031422; C:RecQ family helicase-topoisomerase III complex; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR   Gene3D; 1.10.8.1020; -; 1.
DR   Gene3D; 2.40.50.770; -; 1.
DR   InterPro; IPR033472; DUF1767.
DR   InterPro; IPR032199; RMI1_C.
DR   InterPro; IPR013894; RMI1_N.
DR   InterPro; IPR042470; RMI1_N_C_sf.
DR   InterPro; IPR044881; RMI1_N_N_sf.
DR   Pfam; PF16099; RMI1_C; 1.
DR   Pfam; PF08585; RMI1_N; 1.
DR   SMART; SM01161; DUF1767; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..627
FT                   /note="RecQ-mediated genome instability protein 1"
FT                   /id="PRO_0000361550"
FT   REGION          362..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..471
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   627 AA;  69236 MW;  32E3B82F0871E55C CRC64;
     MSTPNVTARV ETWLSSTWHV KVPLTWLEAC INWIQEENGG GNLSQAQISR QVFEQWLLTD
     LRDLEYPILP DGILDAPKGE LSGFYSLQID SLLDVSQPAY SQLQKIRGKS TVNEEVTANT
     QAFQKPWEAK PTRMLMLQLT DGIHQIQGME YQPVPVLHSN LPPGTKITVH GNVAYRLGVL
     LLKPENVKLL GGEVDALLEE YSQERVLARL LGEAENPDSV RQPGHEQIVP GPVDELGQTL
     GPSDEELLAS LDENNDFILN NETSLESGYC SRSNNFSATS CSLTTYNENT TGFPLQQESV
     NLLPRSDEQT PPSVEYNDAF LNDFPLEDDI LLEEEIQREL EEVPSVARNG NVNLSTERIP
     HTYRSSCGSS LNETSEKDDG CGSEKPVEVT SKQKNLARTV STGDGTSTGG SLQCNSVSQA
     CSSAIVLLKN PHEERRNDLG PDESSCQSRH APDSRQLNKD PVSSSKTDPE ADQQAILCRP
     GNACDLDLDS PPFTYISLLL AKKPETITLV KVKCFIVTLT GNLTSSNGSW GIKAKVSDGS
     AYLEVDFADD ILTSLIGFSV PEMHTLRKDP ALQPKLKDGL ERCQKQLIDL CCLMTIEFNP
     FQSKATVLIL QDTDARHLEQ LKKRLNK