ID   RMI1_DANRE              Reviewed;         519 AA.
AC   Q7ZVM9;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=RecQ-mediated genome instability protein 1;
GN   Name=rmi1; ORFNames=zgc:55882;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the RMI complex, a complex that plays
CC       an important role in the processing of homologous recombination
CC       intermediates to limit DNA crossover formation in cells. Promotes TOP3A
CC       binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-
CC       mediated dissolution. Required for BLM phosphorylation during mitosis.
CC       Within the BLM complex, required for BLM and TOP3A stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RMI complex, containing at least TOP3A, RMI1
CC       and RMI2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RMI1 family. {ECO:0000305}.
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DR   EMBL; BC045482; AAH45482.1; -; mRNA.
DR   RefSeq; NP_956474.1; NM_200180.1.
DR   AlphaFoldDB; Q7ZVM9; -.
DR   SMR; Q7ZVM9; -.
DR   STRING; 7955.ENSDARP00000060656; -.
DR   PaxDb; Q7ZVM9; -.
DR   GeneID; 393149; -.
DR   KEGG; dre:393149; -.
DR   CTD; 80010; -.
DR   ZFIN; ZDB-GENE-040426-829; rmi1.
DR   eggNOG; KOG3683; Eukaryota.
DR   InParanoid; Q7ZVM9; -.
DR   PhylomeDB; Q7ZVM9; -.
DR   Reactome; R-DRE-5685938; HDR through Single Strand Annealing (SSA).
DR   Reactome; R-DRE-5685942; HDR through Homologous Recombination (HRR).
DR   Reactome; R-DRE-5693568; Resolution of D-loop Structures through Holliday Junction Intermediates.
DR   Reactome; R-DRE-5693579; Homologous DNA Pairing and Strand Exchange.
DR   Reactome; R-DRE-5693607; Processing of DNA double-strand break ends.
DR   Reactome; R-DRE-5693616; Presynaptic phase of homologous DNA pairing and strand exchange.
DR   Reactome; R-DRE-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-DRE-69473; G2/M DNA damage checkpoint.
DR   PRO; PR:Q7ZVM9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0031422; C:RecQ family helicase-topoisomerase III complex; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR   Gene3D; 1.10.8.1020; -; 1.
DR   Gene3D; 2.40.50.770; -; 1.
DR   InterPro; IPR033472; DUF1767.
DR   InterPro; IPR032199; RMI1_C.
DR   InterPro; IPR013894; RMI1_N.
DR   InterPro; IPR042470; RMI1_N_C_sf.
DR   InterPro; IPR044881; RMI1_N_N_sf.
DR   Pfam; PF16099; RMI1_C; 1.
DR   Pfam; PF08585; RMI1_N; 1.
DR   SMART; SM01161; DUF1767; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..519
FT                   /note="RecQ-mediated genome instability protein 1"
FT                   /id="PRO_0000361551"
FT   REGION          238..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..332
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..353
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   519 AA;  57581 MW;  7C15029D6B64E525 CRC64;
     MSVGEVQVIQ AWLRSEWHIQ VPPAWLDACV NWIKEEADRA SIPQSQLNQR VLEQWLLTDL
     RDLAHPVLPE RISEAQKTVL SNRCCVQMDS LLDVSQPAYN QLQRIRGTDC SNDQVSAVTQ
     ETQRPWEAKP TRMLMLQLTD GVQNLEGMEY RPIPALNANL PPGTKLQLVG PIAVRLGVLL
     LKAENIKVLG GEVEQLLEIH SQSRVLCGTL GLPEETHPQQ EPDGLVASVA DSGYSSLASE
     ASLRHPQSQP LPQISRQDDW DMDEIPDDDF RSIPDHFDDL PQNNNPLEDV PEDFDDIPLD
     ELDNVMCPID VEVSAGTLED PERNKHDSSL LNGSKPEEVS FPSRSRLGNT YQSRTLNKVP
     NTSLASCSTS TLDSSACKET PMYLCSLQAG CWPPKSPQVF RLQAFIVTLV GNLRISGGVW
     KLGATISDGS GYLDVDLSDN MLSELIGFSA AETRVLRKDL ARRGEVDSGI QHCQRELVDM
     CCMMSVQVDL TGRGVVLSAS PISDRECSEM QKRVKEARR