ID   RMI1_SCHPO              Reviewed;         235 AA.
AC   Q10160;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=RecQ-mediated genome instability protein 1;
GN   Name=rmi1; ORFNames=SPAC26A3.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=15889139; DOI=10.1038/sj.emboj.7600684;
RA   Chang M., Bellaoui M., Zhang C., Desai R., Morozov P., Delgado-Cruzata L.,
RA   Rothstein R., Freyer G.A., Boone C., Brown G.W.;
RT   "RMI1/NCE4, a suppressor of genome instability, encodes a member of the
RT   RecQ helicase/Topo III complex.";
RL   EMBO J. 24:2024-2033(2005).
CC   -!- FUNCTION: Structure-specific DNA-binding protein with a preference for
CC       cruciform structures. Also binds single-stranded DNA (ssDNA). Functions
CC       together with top3 to maintain genome integrity. Essential for proper
CC       meiotic cell division. Required for normal S-phase progression and DNA
CC       damage response. {ECO:0000269|PubMed:15889139}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RMI1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA93226.1; -; Genomic_DNA.
DR   PIR; T38391; T38391.
DR   RefSeq; NP_594146.1; NM_001019570.2.
DR   AlphaFoldDB; Q10160; -.
DR   SMR; Q10160; -.
DR   BioGRID; 279179; 13.
DR   STRING; 4896.SPAC26A3.03c.1; -.
DR   iPTMnet; Q10160; -.
DR   MaxQB; Q10160; -.
DR   PaxDb; Q10160; -.
DR   PRIDE; Q10160; -.
DR   EnsemblFungi; SPAC26A3.03c.1; SPAC26A3.03c.1:pep; SPAC26A3.03c.
DR   GeneID; 2542729; -.
DR   KEGG; spo:SPAC26A3.03c; -.
DR   PomBase; SPAC26A3.03c; rmi1.
DR   VEuPathDB; FungiDB:SPAC26A3.03c; -.
DR   eggNOG; KOG3683; Eukaryota.
DR   HOGENOM; CLU_1180806_0_0_1; -.
DR   InParanoid; Q10160; -.
DR   OMA; KPWREGR; -.
DR   PhylomeDB; Q10160; -.
DR   PRO; PR:Q10160; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; ISO:PomBase.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0031422; C:RecQ family helicase-topoisomerase III complex; IDA:PomBase.
DR   GO; GO:0000400; F:four-way junction DNA binding; ISO:PomBase.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; ISO:PomBase.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR   Gene3D; 2.40.50.770; -; 1.
DR   InterPro; IPR033472; DUF1767.
DR   InterPro; IPR039215; RMI1.
DR   InterPro; IPR013894; RMI1_N.
DR   InterPro; IPR042470; RMI1_N_C_sf.
DR   PANTHER; PTHR14790; PTHR14790; 1.
DR   Pfam; PF08585; RMI1_N; 1.
DR   SMART; SM01161; DUF1767; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; DNA damage; DNA-binding; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..235
FT                   /note="RecQ-mediated genome instability protein 1"
FT                   /id="PRO_0000116473"
SQ   SEQUENCE   235 AA;  26632 MW;  D8097F915563AE23 CRC64;
     MNQTTTLSTE LTELGVRVQN RWLQSLLDYL AKKHSTGANT TPQLVMQYLV ASDIRESTTS
     EGAAPYIVSE QHNVRIENTM LLQIVRVREI GISIVNQLEY LNDLEELKKL KGQKVIRLVH
     DESGDEEQND DDGLTEAQDA VQKGSELKKM CRLILEDSNG QRFWGLERKP IKGIQLSTKL
     GTKLLVKNVL VRRGVLMLDP NNTTILGGSI EEWDKDYFPK RLIEELKGEL SKTKA