ID   RMI1_XENLA              Reviewed;         557 AA.
AC   Q6DDH2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=RecQ-mediated genome instability protein 1;
GN   Name=rmi1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the RMI complex, a complex that plays
CC       an important role in the processing of homologous recombination
CC       intermediates to limit DNA crossover formation in cells. Promotes TOP3A
CC       binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-
CC       mediated dissolution. Required for BLM phosphorylation during mitosis.
CC       Within the BLM complex, required for BLM and TOP3A stability (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RMI complex, containing at least TOP3A, RMI1
CC       and RMI2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RMI1 family. {ECO:0000305}.
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DR   EMBL; BC077592; AAH77592.1; -; mRNA.
DR   RefSeq; NP_001086875.1; NM_001093406.1.
DR   AlphaFoldDB; Q6DDH2; -.
DR   SMR; Q6DDH2; -.
DR   BioGRID; 103570; 1.
DR   IntAct; Q6DDH2; 1.
DR   MaxQB; Q6DDH2; -.
DR   DNASU; 446710; -.
DR   GeneID; 446710; -.
DR   KEGG; xla:446710; -.
DR   CTD; 446710; -.
DR   Xenbase; XB-GENE-952474; rmi1.L.
DR   OrthoDB; 531291at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 446710; Expressed in egg cell and 11 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.8.1020; -; 1.
DR   Gene3D; 2.40.50.770; -; 1.
DR   InterPro; IPR033472; DUF1767.
DR   InterPro; IPR032199; RMI1_C.
DR   InterPro; IPR013894; RMI1_N.
DR   InterPro; IPR042470; RMI1_N_C_sf.
DR   InterPro; IPR044881; RMI1_N_N_sf.
DR   Pfam; PF16099; RMI1_C; 1.
DR   Pfam; PF08585; RMI1_N; 1.
DR   SMART; SM01161; DUF1767; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..557
FT                   /note="RecQ-mediated genome instability protein 1"
FT                   /id="PRO_0000361552"
FT   REGION          259..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   557 AA;  61680 MW;  DB1A571799243287 CRC64;
     MMATSGIANR VKTWLISTWH VKVPDPWLEA CINWIQEENG SSLLQAEINK QVFEQWLLTD
     LRDLEFPVLP ANITDSLKCE LNGFHAVQMD SLVDISLPAY SQLQKLKGKD STNEQVTCTT
     QQSQKPWEAK PTRMLMLQLT DGTQHIQAME YRPIQALNAN LSPGTKMVLQ GTIVCRLGVL
     LLKPENVKVL GGEVEALVAE YTQTKVLSRL IGVEDNTVAQ HSNVQEHAAG VAAGELGQAL
     GPSDEDLLAS LEENEEFSIN NGVPSESGYY SRNENSSISS STQHQTQDSI VRCWVDDDIL
     EFSINNGVPS ESGYYSRNEN SSISSSTQHQ TQDSIVRQTS FPMLDQTVVH VNVANNHAIE
     EQFDIDDELF LEEEIQRELE EMSMSQAEVT HGSTDLPTTL SATSHASSAS CTSDQNNIDI
     PPYTYLSTIL ASKSRSITCV KLKSFIVTLN GNLSHSCGLW NIKAKISDGT GYLNVEFSDD
     VLTELIGFTV PEMKTLKKDP SQQSTLMEGL QKCQRMLTDF CGVMTVSYNP AKEEAVVLSL
     QDVTEEIMQS LQKLLRS