RMI2_CHICK
ID RMI2_CHICK Reviewed; 137 AA.
AC Q5ZM20;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=RecQ-mediated genome instability protein 2;
GN Name=RMI2; ORFNames=RCJMB04_3g8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2]
RP FUNCTION.
RX PubMed=18923082; DOI=10.1101/gad.1708608;
RA Xu D., Guo R., Sobeck A., Bachrati C.Z., Yang J., Enomoto T., Brown G.W.,
RA Hoatlin M.E., Hickson I.D., Wang W.;
RT "RMI, a new OB-fold complex essential for Bloom syndrome protein to
RT maintain genome stability.";
RL Genes Dev. 22:2843-2855(2008).
CC -!- FUNCTION: Essential component of the RMI complex, a complex that plays
CC an important role in the processing of homologous recombination
CC intermediates. It is required to regulate sister chromatid segregation
CC and to limit DNA crossover. Essential for the stability, localization,
CC and function of BLM, TOP3A, and complexes containing BLM. In the RMI
CC complex, it is required to target BLM to chromatin and stress-induced
CC nuclear foci and mitotic phosphorylation of BLM.
CC {ECO:0000250|UniProtKB:Q96E14, ECO:0000269|PubMed:18923082}.
CC -!- SUBUNIT: Component of the RMI complex, containing at least TOP3A, RMI1
CC and RMI2. The RMI complex interacts with BLM (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RMI2 family. {ECO:0000305}.
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DR EMBL; AJ719564; CAG31223.1; -; mRNA.
DR RefSeq; NP_001006174.1; NM_001006174.1.
DR RefSeq; XP_015149718.1; XM_015294232.1.
DR AlphaFoldDB; Q5ZM20; -.
DR SMR; Q5ZM20; -.
DR STRING; 9031.ENSGALP00000011578; -.
DR PaxDb; Q5ZM20; -.
DR Ensembl; ENSGALT00000011592; ENSGALP00000011578; ENSGALG00000007155.
DR GeneID; 416628; -.
DR KEGG; gga:416628; -.
DR CTD; 116028; -.
DR VEuPathDB; HostDB:geneid_416628; -.
DR eggNOG; ENOG502S4AN; Eukaryota.
DR GeneTree; ENSGT00390000001653; -.
DR HOGENOM; CLU_147474_0_0_1; -.
DR InParanoid; Q5ZM20; -.
DR OMA; RVSLVWM; -.
DR OrthoDB; 1604165at2759; -.
DR PhylomeDB; Q5ZM20; -.
DR Reactome; R-GGA-5693568; Resolution of D-loop Structures through Holliday Junction Intermediates.
DR PRO; PR:Q5ZM20; -.
DR Proteomes; UP000000539; Chromosome 14.
DR Bgee; ENSGALG00000007155; Expressed in heart and 14 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0031422; C:RecQ family helicase-topoisomerase III complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0043007; P:maintenance of rDNA; IBA:GO_Central.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0033045; P:regulation of sister chromatid segregation; IBA:GO_Central.
DR GO; GO:0071139; P:resolution of recombination intermediates; IEA:Ensembl.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR032245; RMI2.
DR PANTHER; PTHR33962; PTHR33962; 1.
DR Pfam; PF16100; RMI2; 1.
PE 2: Evidence at transcript level;
KW DNA replication; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..137
FT /note="RecQ-mediated genome instability protein 2"
FT /id="PRO_0000297579"
FT DNA_BIND 45..115
FT /note="OB"
SQ SEQUENCE 137 AA; 14672 MW; FF4E7BBDB4D43FE6 CRC64;
MAGEAASPPL KVLAAQLRAA GRGAGGTWRL SRTETGRAPL CLRAVWMQGT VLQVERGGGG
SARLRDGSGH FTVLGVEDVP RGRPCLSAGK YVMVMGMVRA CSPEPVLRAI KMTDLSENPV
HEEMWGLEVE ELHRVIP
