ID   RMLCL_STRP6             Reviewed;         197 AA.
AC   Q5XCG7; P82566;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Protein RmlC homolog {ECO:0000305};
DE            EC=5.1.3.- {ECO:0000305};
GN   Name=rfbC; OrderedLocusNames=M6_Spy0761;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 17-29; 45-53; 60-68; 101-117 AND 182-195, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=JRS4 / Serotype M6 {ECO:0000269|Ref.2};
RA   Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J.,
RA   VanBogelen R.A.;
RT   "Two-dimensional gel electrophoresis map of Streptococcus pyogenes
RT   proteins.";
RL   Submitted (MAY-2000) to UniProtKB.
CC   -!- FUNCTION: Could catalyze a 3,5-epimerization.
CC       {ECO:0000250|UniProtKB:P26394}.
CC   -!- MASS SPECTROMETRY: Mass=22437.47; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000003; AAT86896.1; -; Genomic_DNA.
DR   RefSeq; WP_002990099.1; NC_006086.1.
DR   AlphaFoldDB; Q5XCG7; -.
DR   SMR; Q5XCG7; -.
DR   EnsemblBacteria; AAT86896; AAT86896; M6_Spy0761.
DR   GeneID; 57852534; -.
DR   GeneID; 66901061; -.
DR   KEGG; spa:M6_Spy0761; -.
DR   HOGENOM; CLU_090940_2_0_9; -.
DR   OMA; RGVFLEW; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0008830; F:dTDP-4-dehydrorhamnose 3,5-epimerase activity; IEA:InterPro.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR000888; dTDP_sugar_isom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR21047; PTHR21047; 1.
DR   Pfam; PF00908; dTDP_sugar_isom; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Isomerase.
FT   CHAIN           1..197
FT                   /note="Protein RmlC homolog"
FT                   /id="PRO_0000259667"
FT   ACT_SITE        76
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HU21"
FT   ACT_SITE        140
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HU21"
SQ   SEQUENCE   197 AA;  22437 MW;  D4C926530934706F CRC64;
     MTETFFDKPL ACREIKEIPG LLEFDIPVRG DNRGWFKENF QKEKMLPIGF PERFFEEGKL
     QNNVSFSRQH VLRGLHAEPW DKYISVADDG KVLGAWVDLR EGETFGNVYQ TVIDASKGMF
     VPRGVANGFQ VLSETVSYSY LVNDYWALDL KPKYAFVNYA DPSLGITWEN LAAAEVSEAD
     KNHPLLSDVK PLKPKDL