RMND1_MOUSE
ID RMND1_MOUSE Reviewed; 450 AA.
AC Q8CI78; Q3TQK1; Q8BW19; Q8R2S0; Q8VCK4; Q9CV49; Q9CVN0;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Required for meiotic nuclear division protein 1 homolog;
DE Flags: Precursor;
GN Name=Rmnd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Kidney, Pancreas, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for mitochondrial translation, possibly by
CC coordinating the assembly or maintenance of the mitochondrial ribosome.
CC {ECO:0000250|UniProtKB:Q9NWS8}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250|UniProtKB:Q9NWS8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NWS8}.
CC Note=May be localized in mitochondrial RNA granules.
CC {ECO:0000250|UniProtKB:Q9NWS8}.
CC -!- SIMILARITY: Belongs to the RMD1/sif2 family. {ECO:0000305}.
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DR EMBL; AK007323; BAB24958.1; -; mRNA.
DR EMBL; AK009625; BAB26398.1; -; mRNA.
DR EMBL; AK075603; BAC35851.1; -; mRNA.
DR EMBL; AK163523; BAE37381.1; -; mRNA.
DR EMBL; BC019572; AAH19572.1; -; mRNA.
DR EMBL; BC027299; AAH27299.1; -; mRNA.
DR EMBL; BC036150; AAH36150.1; -; mRNA.
DR CCDS; CCDS56675.1; -.
DR RefSeq; NP_079619.4; NM_025343.5.
DR RefSeq; XP_006512540.1; XM_006512477.3.
DR RefSeq; XP_006512541.1; XM_006512478.3.
DR RefSeq; XP_017169542.1; XM_017314053.1.
DR RefSeq; XP_017169543.1; XM_017314054.1.
DR RefSeq; XP_017169544.1; XM_017314055.1.
DR AlphaFoldDB; Q8CI78; -.
DR STRING; 10090.ENSMUSP00000043355; -.
DR PhosphoSitePlus; Q8CI78; -.
DR SwissPalm; Q8CI78; -.
DR EPD; Q8CI78; -.
DR jPOST; Q8CI78; -.
DR MaxQB; Q8CI78; -.
DR PaxDb; Q8CI78; -.
DR PeptideAtlas; Q8CI78; -.
DR PRIDE; Q8CI78; -.
DR ProteomicsDB; 299838; -.
DR Antibodypedia; 33335; 97 antibodies from 18 providers.
DR Ensembl; ENSMUST00000042251; ENSMUSP00000043355; ENSMUSG00000019763.
DR GeneID; 66084; -.
DR KEGG; mmu:66084; -.
DR UCSC; uc007ehd.2; mouse.
DR CTD; 55005; -.
DR MGI; MGI:1913334; Rmnd1.
DR VEuPathDB; HostDB:ENSMUSG00000019763; -.
DR eggNOG; KOG2861; Eukaryota.
DR GeneTree; ENSGT00390000013337; -.
DR HOGENOM; CLU_011220_4_2_1; -.
DR InParanoid; Q8CI78; -.
DR OMA; QVIHVQT; -.
DR OrthoDB; 954411at2759; -.
DR PhylomeDB; Q8CI78; -.
DR TreeFam; TF105813; -.
DR BioGRID-ORCS; 66084; 0 hits in 69 CRISPR screens.
DR ChiTaRS; Rmnd1; mouse.
DR PRO; PR:Q8CI78; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CI78; protein.
DR Bgee; ENSMUSG00000019763; Expressed in spermatid and 162 other tissues.
DR ExpressionAtlas; Q8CI78; baseline and differential.
DR Genevisible; Q8CI78; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR InterPro; IPR003734; DUF155.
DR Pfam; PF02582; DUF155; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Protein biosynthesis; Reference proteome; Transit peptide.
FT TRANSIT 1..5
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 6..450
FT /note="Required for meiotic nuclear division protein 1
FT homolog"
FT /id="PRO_0000229734"
FT CONFLICT 41
FT /note="C -> S (in Ref. 1; BAC35851)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="I -> R (in Ref. 2; AAH27299)"
FT /evidence="ECO:0000305"
FT CONFLICT 74..76
FT /note="ITS -> VTW (in Ref. 2; AAH27299)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="S -> T (in Ref. 2; AAH27299)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 450 AA; 51843 MW; E085AE029FFA3822 CRC64;
MPSRLLHTLA SLHSISAKAH QCQRLTWLTL RPLRKSESTT CHNGLTIQQH LHSFFPSITA
DSLNKPEILE MSRITSDTSR LFPLNAVHWL DGKEHWPSMH PFGTHRSMTH KPNLLCSKWF
IKAVKRHHSS VSNEALVPKQ DLPQIKRPLK ASRTRQPSRT NLPDLSVNED LMQCTAFATA
DEYHLGSLSQ ELVSCGYVEV TSLPRDAANI LVMGVESSAK EGDPGTIFLF REGAAVFWNV
KEKTMKHVMQ VLERHETQPY EVALVHWENE ELNYIKTEGQ SKLHRGEIKL NSELDLDDAI
LEKFAFSNAL CLSVKLAIWE ATLDKFIESI QSIPEALKAG KKVKLSHKEV MQKMGELFAL
RHRINLSSDF LITPDFYWDR ANLEELYDKT CQFLSITRRV KVMNEKLQHC MELTDLMRNH
LNEKRALRLE WMIVILITIE VMFELGRVFF
