RMR1_YEAST
ID RMR1_YEAST Reviewed; 241 AA.
AC P53060; D6VV85;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Reduced meiotic recombination protein 1;
GN Name=RMR1; OrderedLocusNames=YGL250W; ORFNames=NRC245;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972578;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1555::aid-yea43>3.0.co;2-q;
RA Coissac E., Maillier E., Robineau S., Netter P.;
RT "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome
RT VII of Saccharomyces cerevisiae.";
RL Yeast 12:1555-1562(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP SUMOYLATION.
RX PubMed=15590687; DOI=10.1074/jbc.m413209200;
RA Hannich J.T., Lewis A., Kroetz M.B., Li S.J., Heide H., Emili A.,
RA Hochstrasser M.;
RT "Defining the SUMO-modified proteome by multiple approaches in
RT Saccharomyces cerevisiae.";
RL J. Biol. Chem. 280:4102-4110(2005).
RN [8]
RP FUNCTION.
RX PubMed=18069899; DOI=10.1371/journal.pgen.0030222;
RA Jordan P.W., Klein F., Leach D.R.;
RT "Novel roles for selected genes in meiotic DNA processing.";
RL PLoS Genet. 3:E222-E222(2007).
CC -!- FUNCTION: Required for normal levels of gene conversion events during
CC meiosis. {ECO:0000269|PubMed:18069899}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- PTM: Sumoylated. {ECO:0000269|PubMed:15590687}.
CC -!- MISCELLANEOUS: Present with 1820 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RMR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA64137.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA96970.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X94357; CAA64137.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z72772; CAA96970.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006941; DAA07869.1; -; Genomic_DNA.
DR PIR; S61611; S61611.
DR RefSeq; NP_011264.2; NM_001181116.1.
DR AlphaFoldDB; P53060; -.
DR BioGRID; 33029; 170.
DR DIP; DIP-4375N; -.
DR IntAct; P53060; 7.
DR MINT; P53060; -.
DR STRING; 4932.YGL250W; -.
DR MaxQB; P53060; -.
DR PaxDb; P53060; -.
DR PRIDE; P53060; -.
DR EnsemblFungi; YGL250W_mRNA; YGL250W; YGL250W.
DR GeneID; 852642; -.
DR KEGG; sce:YGL250W; -.
DR SGD; S000003219; RMR1.
DR VEuPathDB; FungiDB:YGL250W; -.
DR eggNOG; ENOG502RZ15; Eukaryota.
DR HOGENOM; CLU_065860_0_0_1; -.
DR InParanoid; P53060; -.
DR OMA; TRPRFVS; -.
DR BioCyc; YEAST:G3O-30720-MON; -.
DR PRO; PR:P53060; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53060; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0006311; P:meiotic gene conversion; IMP:SGD.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
DR InterPro; IPR018822; UPF0646.
DR Pfam; PF10336; DUF2420; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Nucleus; Reference proteome; Ubl conjugation.
FT CHAIN 1..241
FT /note="Reduced meiotic recombination protein 1"
FT /id="PRO_0000202705"
SQ SEQUENCE 241 AA; 27709 MW; E77D9C8D241CA99A CRC64;
MSEEEAHKTV EVDDVGVQLD EGDEEDLLEY DDELVEEQPS DARIRNVAET LMKSELPKVT
VEYKDTTFLL FTSDDKNESN NPIICENAAL YQRPMGEFME SIRKFMGNRF GRLAFATKEL
VLQLKSLDLT LFEDNVYNNH ISFSDVYTIF KILKERSESN FETDIPTHLA IELSTRPRFV
SRYNALVELT ESSATLKNIK PFSNDETHPL IVDDNDQYTH QNTSEVIVMD IDDDVGEDSE
D
