RMR4_ARATH
ID RMR4_ARATH Reviewed; 448 AA.
AC Q0WPW5; Q9M0N7;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Receptor homology region, transmembrane domain- and RING domain-containing protein 4;
DE Short=AtRMR4;
DE Flags: Precursor;
GN Name=RMR4; OrderedLocusNames=At4g09560; ORFNames=T15G18.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the trafficking of vacuolar proteins. May
CC function as a sorting receptor for protein trafficking to the protein
CC storage vacuole (PSV) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Prevacuolar compartment membrane {ECO:0000250}.
CC Protein storage vacuole membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB78079.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL161515; CAB78079.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82765.1; -; Genomic_DNA.
DR EMBL; AK228945; BAF00834.1; -; mRNA.
DR PIR; F85097; F85097.
DR RefSeq; NP_192694.2; NM_117024.4.
DR AlphaFoldDB; Q0WPW5; -.
DR SMR; Q0WPW5; -.
DR STRING; 3702.AT4G09560.1; -.
DR iPTMnet; Q0WPW5; -.
DR PaxDb; Q0WPW5; -.
DR PRIDE; Q0WPW5; -.
DR EnsemblPlants; AT4G09560.1; AT4G09560.1; AT4G09560.
DR GeneID; 826540; -.
DR Gramene; AT4G09560.1; AT4G09560.1; AT4G09560.
DR KEGG; ath:AT4G09560; -.
DR Araport; AT4G09560; -.
DR TAIR; locus:2133697; AT4G09560.
DR eggNOG; KOG4628; Eukaryota.
DR HOGENOM; CLU_035275_2_0_1; -.
DR InParanoid; Q0WPW5; -.
DR OMA; QETKVEM; -.
DR OrthoDB; 1487241at2759; -.
DR PhylomeDB; Q0WPW5; -.
DR PRO; PR:Q0WPW5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q0WPW5; baseline and differential.
DR Genevisible; Q0WPW5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032586; C:protein storage vacuole membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd02123; PA_C_RZF_like; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR044744; ZNRF4/RNF13/RNF167_PA.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Metal-binding; Protein transport;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport;
KW Vacuole; Zinc; Zinc-finger.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..448
FT /note="Receptor homology region, transmembrane domain- and
FT RING domain-containing protein 4"
FT /id="PRO_0000425118"
FT TOPO_DOM 21..165
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 74..146
FT /note="PA"
FT ZN_FING 234..276
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 281..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 62..89
FT /evidence="ECO:0000255"
SQ SEQUENCE 448 AA; 49723 MW; 7D1A0DAEB690DACD CRC64;
MIRSSIVILS LLLISHLVSA KVLLIGNSTS LSFDDVEATF TPMIKRSDQG GVLYVAEPLD
ACSDLVNTVN VKNGTTVSPP YVLIIRGGCS FEDKIRNAQK AGYKAAIVYD YEDFGFLVSM
AGNPSGVLIY GTFVSKATGE VLKEYAGRTD FEVWLMPSFE TSAWSIMAIS FISLLAMSAV
LATCFFVRRH RVRRRRILAL NGNDFHRMPK SMIIRMPTTI FNGICDEATT SILCCICLEN
YEKGDKLRIL PCHHKFHVAC VDLWLGQRKS FCPVCKRDAR SISTDKPPSE HTPFLSRTPS
MTPTSSFLLS SSSTTPLQSS HELPISIRVD PSLPSTSMQP HTVPMYLSHS RSHTSFQNGS
NRFSRPIPVS RSSADLRNAV SQRSYNSPHQ VSLPRFLHSR YTHILGPGNA SRSQVVGLLT
SQREHSLHQN DSRRSFIHFA SASSLPGW
