RMR5_ARATH
ID RMR5_ARATH Reviewed; 318 AA.
AC F4HZZ5; Q9LQG6;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Receptor homology region, transmembrane domain- and RING domain-containing protein 5;
DE Short=AtRMR5;
DE Flags: Precursor;
GN Name=RMR5; OrderedLocusNames=At1g35630; ORFNames=F15O4.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- FUNCTION: Involved in the trafficking of vacuolar proteins. May
CC function as a sorting receptor for protein trafficking to the protein
CC storage vacuole (PSV) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Prevacuolar compartment membrane {ECO:0000250}.
CC Protein storage vacuole membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79351.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BX818705; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AC007887; AAF79351.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31820.1; -; Genomic_DNA.
DR EMBL; BX818705; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; H86477; H86477.
DR RefSeq; NP_174800.2; NM_103264.3.
DR AlphaFoldDB; F4HZZ5; -.
DR SMR; F4HZZ5; -.
DR STRING; 3702.AT1G35630.1; -.
DR PaxDb; F4HZZ5; -.
DR PRIDE; F4HZZ5; -.
DR EnsemblPlants; AT1G35630.1; AT1G35630.1; AT1G35630.
DR GeneID; 840463; -.
DR Gramene; AT1G35630.1; AT1G35630.1; AT1G35630.
DR KEGG; ath:AT1G35630; -.
DR Araport; AT1G35630; -.
DR TAIR; locus:2014726; AT1G35630.
DR eggNOG; KOG4628; Eukaryota.
DR HOGENOM; CLU_035275_0_0_1; -.
DR InParanoid; F4HZZ5; -.
DR OMA; ICIDDYC; -.
DR OrthoDB; 1487241at2759; -.
DR PRO; PR:F4HZZ5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HZZ5; baseline and differential.
DR Genevisible; F4HZZ5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032586; C:protein storage vacuole membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd02123; PA_C_RZF_like; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR044744; ZNRF4/RNF13/RNF167_PA.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Metal-binding; Protein transport;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport;
KW Vacuole; Zinc; Zinc-finger.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..318
FT /note="Receptor homology region, transmembrane domain- and
FT RING domain-containing protein 5"
FT /id="PRO_0000425119"
FT TOPO_DOM 22..163
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 70..143
FT /note="PA"
FT ZN_FING 233..275
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 62..87
FT /evidence="ECO:0000255"
SQ SEQUENCE 318 AA; 34916 MW; 6117AFCFF23ABE27 CRC64;
MNYSWITIMS LLVICKLASA KVVLIGKNTI LSFDDVEATF TPIVRNSGEC GILYVAEPLE
ACSDITNMAE KRSKYRSSYV LIVLGGCSFE EKVRKAQKAG YKAAIVYNDG YDELLVPMAG
NSSGVDIHGL LVTRASGEVL KGYADQDEMK LWLIPGFGIS SWSIMGITFI SLLAMSAILA
TCFVVRRHQI RQSVRDLPHG GQGLSCMPRD LLQSMPTEVY SGVLEESSTS VTCAICIDDY
CVGEKLRILP CKHKYHAVCI DSWLGRCRSF CPVCKQNPRT GNDVPPASET TPLISPSPNS
ITSLQSFYDL PIVVRVYL
