RMXL3_HUMAN
ID RMXL3_HUMAN Reviewed; 1067 AA.
AC Q8N7X1; B4DXC0;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=RNA-binding motif protein, X-linked-like-3;
GN Name=RBMXL3; Synonyms=CXorf55;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- CAUTION: Encoded in intron of the LRCH2 gene. {ECO:0000305}.
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DR EMBL; AK301904; BAG63332.1; -; mRNA.
DR EMBL; AK097568; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL589786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55478.1; -.
DR RefSeq; NP_001138818.1; NM_001145346.1.
DR AlphaFoldDB; Q8N7X1; -.
DR SMR; Q8N7X1; -.
DR BioGRID; 126588; 13.
DR IntAct; Q8N7X1; 2.
DR STRING; 9606.ENSP00000417451; -.
DR iPTMnet; Q8N7X1; -.
DR PhosphoSitePlus; Q8N7X1; -.
DR BioMuta; RBMXL3; -.
DR DMDM; 229485971; -.
DR jPOST; Q8N7X1; -.
DR MassIVE; Q8N7X1; -.
DR MaxQB; Q8N7X1; -.
DR PaxDb; Q8N7X1; -.
DR PeptideAtlas; Q8N7X1; -.
DR PRIDE; Q8N7X1; -.
DR ProteomicsDB; 72340; -.
DR DNASU; 139804; -.
DR Ensembl; ENST00000424776.5; ENSP00000417451.3; ENSG00000175718.10.
DR GeneID; 139804; -.
DR KEGG; hsa:139804; -.
DR MANE-Select; ENST00000424776.5; ENSP00000417451.3; NM_001145346.2; NP_001138818.1.
DR UCSC; uc011mte.2; human.
DR CTD; 139804; -.
DR GeneCards; RBMXL3; -.
DR HGNC; HGNC:26859; RBMXL3.
DR HPA; ENSG00000175718; Tissue enriched (testis).
DR neXtProt; NX_Q8N7X1; -.
DR OpenTargets; ENSG00000175718; -.
DR PharmGKB; PA164725338; -.
DR VEuPathDB; HostDB:ENSG00000175718; -.
DR eggNOG; ENOG502SBHG; Eukaryota.
DR GeneTree; ENSGT00940000162929; -.
DR HOGENOM; CLU_308338_0_0_1; -.
DR InParanoid; Q8N7X1; -.
DR OMA; YEEYRGR; -.
DR OrthoDB; 1248417at2759; -.
DR PhylomeDB; Q8N7X1; -.
DR TreeFam; TF331833; -.
DR PathwayCommons; Q8N7X1; -.
DR SignaLink; Q8N7X1; -.
DR BioGRID-ORCS; 139804; 7 hits in 691 CRISPR screens.
DR GenomeRNAi; 139804; -.
DR Pharos; Q8N7X1; Tdark.
DR PRO; PR:Q8N7X1; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N7X1; protein.
DR Bgee; ENSG00000175718; Expressed in right testis and 1 other tissue.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA-binding.
FT CHAIN 1..1067
FT /note="RNA-binding motif protein, X-linked-like-3"
FT /id="PRO_0000261176"
FT DOMAIN 8..86
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 90..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 394
FT /note="G -> GRSPNAHSGG (in Ref. 1; BAG63332/AK097568)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="G -> S (in Ref. 1; AK097568)"
FT /evidence="ECO:0000305"
FT CONFLICT 640
FT /note="A -> D (in Ref. 1; AK097568)"
FT /evidence="ECO:0000305"
FT CONFLICT 711
FT /note="Y -> C (in Ref. 1; BAG63332)"
FT /evidence="ECO:0000305"
FT CONFLICT 723
FT /note="R -> C (in Ref. 1; BAG63332/AK097568)"
FT /evidence="ECO:0000305"
FT CONFLICT 778
FT /note="R -> H (in Ref. 1; BAG63332)"
FT /evidence="ECO:0000305"
FT CONFLICT 794
FT /note="R -> H (in Ref. 1; AK097568)"
FT /evidence="ECO:0000305"
FT CONFLICT 921
FT /note="P -> S (in Ref. 1; BAG63332)"
FT /evidence="ECO:0000305"
FT CONFLICT 1049
FT /note="R -> G (in Ref. 1; BAG63332)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1067 AA; 114938 MW; CC8D0384670A38C5 CRC64;
MMEADRPEKL FIGGLNLKTD EKALKAEFGK YGHIIKVFLM KDRKTNKSRG FAFVTFESPA
DAKAAARDMN GKYLDGKAIM VAQTIKPAFK SSRWVPPTPG SGSRSRFSHR TRGGGSSPQR
PPSQGRPDDG RGYAGYFDLW PYRAPMPRKR GPPPRHWASP PHKRATPSSL AHSVGCGMRG
KAPTVSGQDG YSGLQPRRWA GPPHKRAVPR SSLARIGGSG MPGKAPAVWG QDGYSGPRVR
EPLPPCRDPG DFVPALRDYS RRYYGHSSVP DYRPLRGDGN QNGYRGRDHE YTDHPSKGSY
REPLKSYGGP CGAAPVWGTP PSYGGGCRYE EYQGNSPDAC SEGRSSEALP VVLPDAYSRD
HSPKAYSGGR SSSSNGYSRS DRYGEEGCYE EYRGRSPDAH SGGRNSSSNS YGQSHHYGGE
GRYEEYRGRS HEARSGGRST DAHSRGRSDD AYSGGHDSSS WSDCCGGGGR YEEYQGRSLD
ANSGGCSPEA YSGGHDNSSW SDRYGVGGHY EENRGHSLDA NSGGRSPDTH SGGHSSSSNS
YGQSHRYGGE GRYEYRGRSH DAHSGGCSAD AYSGGHDSSS QSNRYGGGGC YEEYRGRSLD
ANSGGRSPNA YSGGHDSSSW SHRYGGGGRY EEYRGRSLDA NSGGRSPDAY SGGHDSSGQS
NCYGGGGRYE EYRGRLLDAN SGGRSPDAYS GGHDSSSQSN RYGGGGRYEE YRGHSLDANS
GGRSPDTYSR GHDSSSQSDH YGGGGRSLDA NSSGRLPDAY SGGHDSSSRS HRYGGGGRYE
EYRGRSLDAN SGGRSPNAYS GGHNSSSRND PCRGGGRYEE NRGHSLDANS GGHSPNAYSG
GRDSSSNSYD RSHRYGGGGH YEEYRGRSHD THSRGRSPDA HSGDHYTEAY SRGRDSFSNS
YGRSDHYGRG GCYEEYQGRS PNAYGGGRGL NSSNNSHGRS HRYGGGGRYE EYRGPSPDAH
SGGRDSSIKS YGLSDRYGGG GHYEEYQGSL PDAYSGDHDR SSNSYGRSDR YSRGRDRVGR
PDRGLPLPME TGSPPLHDSY SRSGCRVPRG GGRQGGRFER GEGRSRY
