ID   RN121_CAEEL             Reviewed;         409 AA.
AC   Q09251;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=RING finger protein 121;
GN   Name=rnf-121; ORFNames=C16C10.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=22285439; DOI=10.1016/j.mod.2012.01.003;
RA   Kovacevic I., Ho R., Cram E.J.;
RT   "CCDC-55 is required for larval development and distal tip cell migration
RT   in Caenorhabditis elegans.";
RL   Mech. Dev. 128:548-559(2012).
CC   -!- FUNCTION: Required for the cessation of distal tip cell migration at
CC       the end of larval morphogenesis. {ECO:0000269|PubMed:22285439}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RNF121 family. {ECO:0000305}.
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DR   EMBL; Z46787; CAA86743.1; -; Genomic_DNA.
DR   PIR; T19326; T19326.
DR   RefSeq; NP_497832.2; NM_065431.5.
DR   AlphaFoldDB; Q09251; -.
DR   BioGRID; 47529; 2.
DR   STRING; 6239.C16C10.5; -.
DR   EPD; Q09251; -.
DR   PaxDb; Q09251; -.
DR   PeptideAtlas; Q09251; -.
DR   EnsemblMetazoa; C16C10.5.1; C16C10.5.1; WBGene00007626.
DR   GeneID; 182681; -.
DR   KEGG; cel:CELE_C16C10.5; -.
DR   CTD; 182681; -.
DR   WormBase; C16C10.5; CE49432; WBGene00007626; rnf-121.
DR   eggNOG; KOG1734; Eukaryota.
DR   GeneTree; ENSGT00390000013075; -.
DR   HOGENOM; CLU_055016_1_0_1; -.
DR   InParanoid; Q09251; -.
DR   OrthoDB; 1167893at2759; -.
DR   PhylomeDB; Q09251; -.
DR   PRO; PR:Q09251; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007626; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:WormBase.
DR   GO; GO:0000139; C:Golgi membrane; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IDA:WormBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:WormBase.
DR   GO; GO:0040039; P:inductive cell migration; IMP:WormBase.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IMP:WormBase.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR040176; RNF121/RNF175.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13407; PTHR13407; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..409
FT                   /note="RING finger protein 121"
FT                   /id="PRO_0000056322"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         296..358
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   409 AA;  47627 MW;  6AB33FC9D026C461 CRC64;
     MTFSYFISIF TANLSPTFPC RKVNQLNYFY QLLNLKCFFR SIFKIGHFPR GSPLYLLEKS
     ITFSKIISIF SGHRMGQHGA IRLQNEVQEG MPPPHELTEE EQWAEEHRKM HEKHKGHEAM
     HMEMMVIFMI SVIVGQIFLV TWKRKHFKSY QMCTLIGMLT IPVYVCFNRS WYRFLATWLV
     FCIFSAFIWL KASAQHISGG TPRFVYKWFL FLHKLSYVLG VVGYLIMMGA LLGFHVLFGV
     SQPTLMDAGI LFMFYGVYYG VLGRDFAHIC TARMASRIGY YTPEGLPKKH LEDGVCAVCG
     GRLDDSEHVH DADAVVTTKM VEDEDEKLYK LSCGHVFHEF CIRGWVVVGK LQTCPYCKER
     VDLQRMFKNP WEKPHLFYGK LLDWIRYLVC WQPLIVTAVQ GLTTWMGLE