ID   RN121_XENLA             Reviewed;         327 AA.
AC   Q6DD32;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=RING finger protein 121;
GN   Name=rnf121;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RNF121 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC077797; AAH77797.1; -; mRNA.
DR   RefSeq; NP_001086939.1; NM_001093470.1.
DR   RefSeq; XP_018124218.1; XM_018268729.1.
DR   RefSeq; XP_018124219.1; XM_018268730.1.
DR   AlphaFoldDB; Q6DD32; -.
DR   DNASU; 446774; -.
DR   GeneID; 446774; -.
DR   KEGG; xla:446774; -.
DR   CTD; 446774; -.
DR   Xenbase; XB-GENE-17334924; rnf121.S.
DR   OMA; HQQHMDL; -.
DR   OrthoDB; 1167893at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 446774; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR040176; RNF121/RNF175.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13407; PTHR13407; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..327
FT                   /note="RING finger protein 121"
FT                   /id="PRO_0000261409"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         226..276
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   327 AA;  37939 MW;  05C0E70F8E490258 CRC64;
     MAAVLEVEIG GEAVREAAGE EMDLSELAPE ERWRVEHARM HAKHRGHEAM HAEMVLILIA
     TLVVAQLLLV QWKQRHQRSY NMVTLFQMWI VPVYFTVKLH WWRFLGIWIV FSIITAYITY
     KATRKPLLQT TPRLVYKWFL LLYKMSYATG IVGYIAVMFT LFGLNLLFRI KPEDAMDFGI
     SLLFYGLYYG VLGRDFAELC ADYMASTIGF YSASGMPTKH LSDSVCAVCG QQIFVDVNEE
     GIIENTYRLS CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
     DWLRYLVAWQ PVIIGLVQGI NYCLGLE