ID   RN121_XENTR             Reviewed;         327 AA.
AC   Q6P360;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=RING finger protein 121;
GN   Name=rnf121;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RNF121 family. {ECO:0000305}.
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DR   EMBL; BC064173; AAH64173.1; -; mRNA.
DR   RefSeq; NP_989290.1; NM_203959.1.
DR   AlphaFoldDB; Q6P360; -.
DR   PaxDb; Q6P360; -.
DR   DNASU; 394908; -.
DR   Ensembl; ENSXETT00000051634; ENSXETP00000051634; ENSXETG00000023935.
DR   GeneID; 394908; -.
DR   KEGG; xtr:394908; -.
DR   CTD; 55298; -.
DR   Xenbase; XB-GENE-5888698; rnf121.
DR   eggNOG; KOG1734; Eukaryota.
DR   HOGENOM; CLU_055016_1_0_1; -.
DR   InParanoid; Q6P360; -.
DR   OMA; WFLFSIV; -.
DR   OrthoDB; 1167893at2759; -.
DR   PhylomeDB; Q6P360; -.
DR   TreeFam; TF314357; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023935; Expressed in neurula embryo and 14 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR040176; RNF121/RNF175.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13407; PTHR13407; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..327
FT                   /note="RING finger protein 121"
FT                   /id="PRO_0000261410"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         226..276
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   327 AA;  37915 MW;  DB936A0AEE364C39 CRC64;
     MAAVLEVEIG GEAVREAAGE EVDLSELAPE ERWRVEHARM HAKHRGHEAM HAEMVLILIA
     TLVVAQLLLV QWKQRHQRSY NMVTLFQMWI VPVYFTVKLH WWRFLGIWFL FSIVTAFVTY
     KATRKPLVQT TPRLVYKWFL LLYKMSYATG IVGYIAVMFT LFGLNLLFRI KPEDAMDFGI
     SLLFYGLYYG VLGRDFAEMC ADYMASTIGF YSASGMPTKH LSDSVCAVCG QQIFVDVNEE
     GIIENTYRLS CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
     DWLRYLVAWQ PVIIGLVQGI NYCLGLE