RN122_HUMAN
ID RN122_HUMAN Reviewed; 155 AA.
AC Q9H9V4; Q52LK3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=RING finger protein 122;
GN Name=RNF122;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16778963;
RA Wang L., Shi T.P., Wang L., Yu C.F., Zeng L.E., Wang J., Wang L.;
RT "Cloning, expression and subcellular localization of a novel human gene
RT -- RNF122.";
RL Beijing Da Xue Xue Bao 38:239-243(2006).
RN [4]
RP FUNCTION.
RX PubMed=16751333; DOI=10.1177/1087057106286654;
RA Wang L., Gao X., Gao P., Deng W., Yu P., Ma J., Guo J., Wang X., Cheng H.,
RA Zhang C., Yu C., Ma X., Lv B., Lu Y., Shi T., Ma D.;
RT "Cell-based screening and validation of human novel genes associated with
RT cell viability.";
RL J. Biomol. Screen. 11:369-376(2006).
CC -!- FUNCTION: May induce necrosis and apoptosis. May play a role in cell
CC viability. {ECO:0000269|PubMed:16751333}.
CC -!- INTERACTION:
CC Q9H9V4; P29972: AQP1; NbExp=3; IntAct=EBI-2129998, EBI-745213;
CC Q9H9V4; O95674: CDS2; NbExp=3; IntAct=EBI-2129998, EBI-3913685;
CC Q9H9V4; O60883: GPR37L1; NbExp=3; IntAct=EBI-2129998, EBI-2927498;
CC Q9H9V4; Q9Y342: PLLP; NbExp=3; IntAct=EBI-2129998, EBI-3919291;
CC Q9H9V4; Q59EV6: PPGB; NbExp=3; IntAct=EBI-2129998, EBI-14210385;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16778963}.
CC Endoplasmic reticulum {ECO:0000269|PubMed:16778963}. Membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed in several tissues and cell lines.
CC {ECO:0000269|PubMed:16778963}.
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DR EMBL; AK022588; BAB14115.1; -; mRNA.
DR EMBL; BC093884; AAH93884.1; -; mRNA.
DR EMBL; BC101573; AAI01574.1; -; mRNA.
DR CCDS; CCDS6091.1; -.
DR RefSeq; NP_079063.2; NM_024787.3.
DR AlphaFoldDB; Q9H9V4; -.
DR SMR; Q9H9V4; -.
DR BioGRID; 122936; 15.
DR IntAct; Q9H9V4; 10.
DR STRING; 9606.ENSP00000256257; -.
DR iPTMnet; Q9H9V4; -.
DR PhosphoSitePlus; Q9H9V4; -.
DR BioMuta; RNF122; -.
DR DMDM; 110816410; -.
DR jPOST; Q9H9V4; -.
DR MassIVE; Q9H9V4; -.
DR MaxQB; Q9H9V4; -.
DR PaxDb; Q9H9V4; -.
DR PeptideAtlas; Q9H9V4; -.
DR PRIDE; Q9H9V4; -.
DR ProteomicsDB; 81364; -.
DR Antibodypedia; 1235; 176 antibodies from 24 providers.
DR DNASU; 79845; -.
DR Ensembl; ENST00000256257.2; ENSP00000256257.1; ENSG00000133874.2.
DR GeneID; 79845; -.
DR KEGG; hsa:79845; -.
DR MANE-Select; ENST00000256257.2; ENSP00000256257.1; NM_024787.3; NP_079063.2.
DR UCSC; uc003xjo.3; human.
DR CTD; 79845; -.
DR DisGeNET; 79845; -.
DR GeneCards; RNF122; -.
DR HGNC; HGNC:21147; RNF122.
DR HPA; ENSG00000133874; Low tissue specificity.
DR neXtProt; NX_Q9H9V4; -.
DR OpenTargets; ENSG00000133874; -.
DR PharmGKB; PA134892945; -.
DR VEuPathDB; HostDB:ENSG00000133874; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000159152; -.
DR HOGENOM; CLU_142341_0_0_1; -.
DR InParanoid; Q9H9V4; -.
DR OMA; ANKSCTM; -.
DR OrthoDB; 1625209at2759; -.
DR PhylomeDB; Q9H9V4; -.
DR PathwayCommons; Q9H9V4; -.
DR SignaLink; Q9H9V4; -.
DR BioGRID-ORCS; 79845; 9 hits in 1118 CRISPR screens.
DR ChiTaRS; RNF122; human.
DR GeneWiki; RNF122; -.
DR GenomeRNAi; 79845; -.
DR Pharos; Q9H9V4; Tdark.
DR PRO; PR:Q9H9V4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9H9V4; protein.
DR Bgee; ENSG00000133874; Expressed in left uterine tube and 116 other tissues.
DR Genevisible; Q9H9V4; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IMP:UniProtKB.
DR GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; IDA:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
DR GO; GO:0051865; P:protein autoubiquitination; IMP:UniProtKB.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..155
FT /note="RING finger protein 122"
FT /id="PRO_0000247852"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 93..134
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CONFLICT 70
FT /note="E -> D (in Ref. 1; BAB14115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 155 AA; 17475 MW; E86B8E6F4954457B CRC64;
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM LSLIFCCYFI
SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF KGKDELGVLP CQHAFHRKCL
VKWLEVRCVC PMCNKPIASP SEATQNIGIL LDELV
