RN122_MOUSE
ID RN122_MOUSE Reviewed; 155 AA.
AC Q8BP31; Q80VA7; Q8BGD3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=RING finger protein 122;
GN Name=Rnf122;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Egg, Forelimb, Kidney, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May induce necrosis and apoptosis. May play a role in cell
CC viability (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus. Endoplasmic reticulum
CC {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH50268.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK077856; BAC37035.1; -; mRNA.
DR EMBL; AK085376; BAC39436.1; -; mRNA.
DR EMBL; AK171823; BAE42682.1; -; mRNA.
DR EMBL; AK136206; BAE22874.1; -; mRNA.
DR EMBL; BC038399; AAH38399.1; -; mRNA.
DR EMBL; BC050268; AAH50268.1; ALT_INIT; mRNA.
DR CCDS; CCDS90381.1; -.
DR RefSeq; NP_780345.1; NM_175136.2.
DR RefSeq; XP_006509253.1; XM_006509190.3.
DR AlphaFoldDB; Q8BP31; -.
DR SMR; Q8BP31; -.
DR STRING; 10090.ENSMUSP00000040478; -.
DR iPTMnet; Q8BP31; -.
DR PhosphoSitePlus; Q8BP31; -.
DR PaxDb; Q8BP31; -.
DR PRIDE; Q8BP31; -.
DR Antibodypedia; 1235; 176 antibodies from 24 providers.
DR DNASU; 68867; -.
DR Ensembl; ENSMUST00000217278; ENSMUSP00000150893; ENSMUSG00000039328.
DR GeneID; 68867; -.
DR KEGG; mmu:68867; -.
DR UCSC; uc009ljd.1; mouse.
DR CTD; 79845; -.
DR MGI; MGI:1916117; Rnf122.
DR VEuPathDB; HostDB:ENSMUSG00000039328; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000159152; -.
DR InParanoid; Q8BP31; -.
DR OMA; ANKSCTM; -.
DR OrthoDB; 1625209at2759; -.
DR PhylomeDB; Q8BP31; -.
DR BioGRID-ORCS; 68867; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BP31; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BP31; protein.
DR Bgee; ENSMUSG00000039328; Expressed in animal zygote and 162 other tissues.
DR ExpressionAtlas; Q8BP31; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISS:UniProtKB.
DR GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..155
FT /note="RING finger protein 122"
FT /id="PRO_0000247853"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 93..134
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CONFLICT 91
FT /note="Missing (in Ref. 1; BAC39436 and 2; AAH38399)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 155 AA; 17448 MW; F2AB6769825543A0 CRC64;
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM LSLIFCCYFI
SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF KGKDELGVLP CQHAFHRKCL
VKWLEVRCVC PMCNKPIAGP TETSQSIGIL LDELV
