ID   RN145_DANRE             Reviewed;         685 AA.
AC   Q7ZWF4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=RING finger protein 145;
GN   Name=rnf145; ORFNames=zgc:56435;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC049437; AAH49437.1; -; mRNA.
DR   RefSeq; NP_956057.1; NM_199763.1.
DR   AlphaFoldDB; Q7ZWF4; -.
DR   STRING; 7955.ENSDARP00000047514; -.
DR   PaxDb; Q7ZWF4; -.
DR   GeneID; 327056; -.
DR   KEGG; dre:327056; -.
DR   CTD; 327056; -.
DR   ZFIN; ZDB-GENE-030131-5264; rnf145b.
DR   eggNOG; KOG0802; Eukaryota.
DR   InParanoid; Q7ZWF4; -.
DR   OrthoDB; 897451at2759; -.
DR   PhylomeDB; Q7ZWF4; -.
DR   PRO; PR:Q7ZWF4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030097; P:hemopoiesis; IMP:ZFIN.
DR   GO; GO:0061515; P:myeloid cell development; IMP:ZFIN.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025754; TRC8_N_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR011016; Znf_RING-CH.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13705; TRC8_N; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00744; RINGv; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..685
FT                   /note="RING finger protein 145"
FT                   /id="PRO_0000294026"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         537..575
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          582..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..616
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  77649 MW;  D01D61037785D4BF CRC64;
     MAMKARLESV LNVGLRIPSI MLLEVLYRWD VSSFFQKIQR SSLNNNPVFQ YKYIALYLHY
     VGYILSLVLL TLPRQHLVQL YLYVLTALLL FAGHQLSRDY VRGELDSGYE GPLYLEPLSM
     NRFTTALIGQ VVVCTLCSCV MQTRQIWLFS AHLLPLVARL CLVPLETIVF INRFAMIFTG
     LEVLYFIASN LLVPYNLAKT AYRELVQVVE VYGLLALGMS LWNQLVLPVL FMCFWLVLFA
     LQIYTYFSTR DQPPSRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ
     GYRAFMNDNA MHRGMTEGIT LLILAVQTGL IELQVIHRAF LLSIILFIVV ASILQSMLEI
     ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPAYMAYMI CQFFRMDFWL LIIISSSILT
     SLQVLGTLLI YVLFMVEEFR KAPVENMDEV IYYVNGTYRL LEFLVAVCVV AYGVSETLFG
     EWTVMGSTII LVHSYYNVWL RAQLGWQSFL LRRDAVHKIQ SMPTASTLQL QQHNDICSIC
     FQDMKSAVIT PCSHFFHAAC LKKWLYVQET CPLCHGQLKS QLQPTSSPGT PTQGTPAANQ
     NPREVEQEQR QPQVELNTEE GIRAEEMKTS AEQKLGMDLL PGSLNTQPKE CDLVAEGSAG
     TASNLKGDDY YDDDDVSTSD VNCAS