ID   RN145_XENLA             Reviewed;         695 AA.
AC   Q5BIY5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=RING finger protein 145;
GN   Name=rnf145;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC091708; AAH91708.1; -; mRNA.
DR   RefSeq; NP_001089304.1; NM_001095835.1.
DR   AlphaFoldDB; Q5BIY5; -.
DR   DNASU; 734353; -.
DR   GeneID; 734353; -.
DR   KEGG; xla:734353; -.
DR   CTD; 734353; -.
DR   Xenbase; XB-GENE-17334276; rnf145.S.
DR   OrthoDB; 897451at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 734353; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025754; TRC8_N_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR011016; Znf_RING-CH.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13705; TRC8_N; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00744; RINGv; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..695
FT                   /note="RING finger protein 145"
FT                   /id="PRO_0000294027"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         537..575
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          589..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  78494 MW;  FD9A5F6DFAFEFB66 CRC64;
     MGAKEKLEAM LNVALRVPSI MLLDVLYRWD VSSFFQQIQR SSLNKNPLFQ YKYLALNMHY
     VGYILSVVLL TLPRQHLAKL YLYFVAALLL FAGHQISRDY VRSELESGYE GPMHLEPLSM
     NRFITALVGQ LVVCTLCSCV MKTKQIWLFS AHMLPLLARL CLIPIETIVV INKFAMIFTG
     LEVLYFLASN LLVPFNLAKS AYRELAQVVE VYGLLALGMS LWNQLVVPVL FMVFWLVLFA
     LQIYTYFSTR DQPTSRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ
     GYRAFMNDPA MNRGMTEGVT LLILAVQTGL IELQVVHRAF LLSIILFIVV ASILQSMLEI
     ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPSYMAYMI CQFFHMDFWL LIIISSSILT
     SLQVLGTLFV YVLFMIEEFR KEPVENVDDA IYYVNGTYRL LEFLVALCVV AYGVSETVFG
     EWTVMGSMII FIHSYYNVWL RAQLGWKSFL LRRDAVNKIK SLPVSTKEQL EQHNDICSIC
     YQDMNSAVIT PCSHFFHPGC LKKWLYVQET CPLCHCQLKS LSQQAVAESG SSTNPVVEQS
     ANNPPQEPLS AVAATTETLG TVPTCSALEQ EPTMDIEPAE SLVERRGELE VHVSQEEANS
     NSNEVLQRIL TTGKVQPEDL NVKALPPESE VCAGI