ID   RN145_XENTR             Reviewed;         695 AA.
AC   Q0IJ20;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=RING finger protein 145;
GN   Name=rnf145;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC121248; AAI21249.1; -; mRNA.
DR   RefSeq; NP_001072260.1; NM_001078792.1.
DR   RefSeq; XP_012814664.1; XM_012959210.2.
DR   RefSeq; XP_012814666.1; XM_012959212.2.
DR   AlphaFoldDB; Q0IJ20; -.
DR   SMR; Q0IJ20; -.
DR   STRING; 8364.ENSXETP00000035727; -.
DR   PaxDb; Q0IJ20; -.
DR   GeneID; 779713; -.
DR   KEGG; xtr:779713; -.
DR   CTD; 153830; -.
DR   Xenbase; XB-GENE-979193; rnf145.
DR   eggNOG; KOG0802; Eukaryota.
DR   HOGENOM; CLU_016467_1_0_1; -.
DR   InParanoid; Q0IJ20; -.
DR   OMA; HKIQSMP; -.
DR   OrthoDB; 897451at2759; -.
DR   PhylomeDB; Q0IJ20; -.
DR   TreeFam; TF318635; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016361; Expressed in 4-cell stage embryo and 12 other tissues.
DR   ExpressionAtlas; Q0IJ20; baseline.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR025754; TRC8_N_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR011016; Znf_RING-CH.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13705; TRC8_N; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00744; RINGv; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..695
FT                   /note="RING finger protein 145"
FT                   /id="PRO_0000294028"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         537..575
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          585..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..606
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  78567 MW;  C7B7FF624F3313A9 CRC64;
     MGAKEKLEAM LNVALRVPSI MLLDVLYRWD VSSFFKQIQR SSLNNNPLFQ YKYLALNMHY
     VGYILSVVLL TLPRQHLAKL YLYFVAALLL YAGHQISRDY VRSELESGYE GPMHIEPLSM
     NRFITALVGQ LVVCTLCSCV MKTKQIWLFS AHMLPLLARL CLVPIETIVV INKFAMIFTG
     LEVLYFLASN LLVPFNLAKS AYRELAQVVE VYGLLALGMS LWNQLVVPVL FMVFWLVLFA
     LQIYTYFSTR DQPTSRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ
     GYRAFMNDPA MNRGMTEGVT LLILAVQTGL IELQVVHRAF LLSIILFIVV ASILQSMLEI
     ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPSYMAYMI CQFFHMDFWL LIIISSSILT
     SLQVLGTLFI YVLFMIEEFR KEPVENMDDV IYYVNGTYRL LEFLVALCVV AYGVSETVFG
     EWTVMGSMII FIHSYYNVWL RAQLGWKSFL LRRDAVNKIK SLPVATKEQL EQHNDICSIC
     YQDMNSAVIT PCSHFFHPGC LKKWLYVQET CPLCHCQLKS LSQQATGESG SSTNPVSEQS
     ATNPPLGPVS RAEVTTEPLA AVPTRSALEQ EPTMDIKVSG SVEKRIGELE AHFSQGEANL
     NSNEVLQRLQ AKGEANPEDL NVKALPPECE HCAEI