RN148_HUMAN
ID RN148_HUMAN Reviewed; 305 AA.
AC Q8N7C7; A4D0X4; Q8N308;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=RING finger protein 148;
DE Flags: Precursor;
GN Name=RNF148;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=24089095; DOI=10.4238/2013.september.27.7;
RA Liu Y.Q., Tao D.C., Liao S.Y., Yang Y., Ma Y.X., Zhang S.Z.;
RT "Identification of a novel human testicular interstitial gene, RNF148, and
RT its expression regulated by histone deacetylases.";
RL Genet. Mol. Res. 12:4060-4069(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in testis and slightly in
CC pancreas. Mainly present in the interstitial cells of testicular
CC tissues. {ECO:0000269|PubMed:24089095}.
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DR EMBL; AK098654; BAC05367.1; -; mRNA.
DR EMBL; AL133414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236947; EAL24340.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83579.1; -; Genomic_DNA.
DR EMBL; BC029264; AAH29264.1; -; mRNA.
DR CCDS; CCDS47692.1; -.
DR RefSeq; NP_932351.1; NM_198085.1.
DR AlphaFoldDB; Q8N7C7; -.
DR SMR; Q8N7C7; -.
DR BioGRID; 132076; 4.
DR STRING; 9606.ENSP00000388207; -.
DR GlyGen; Q8N7C7; 1 site.
DR iPTMnet; Q8N7C7; -.
DR PhosphoSitePlus; Q8N7C7; -.
DR BioMuta; RNF148; -.
DR DMDM; 269849640; -.
DR MassIVE; Q8N7C7; -.
DR PaxDb; Q8N7C7; -.
DR PeptideAtlas; Q8N7C7; -.
DR PRIDE; Q8N7C7; -.
DR Antibodypedia; 31742; 142 antibodies from 19 providers.
DR DNASU; 378925; -.
DR Ensembl; ENST00000434824.2; ENSP00000388207.1; ENSG00000235631.2.
DR GeneID; 378925; -.
DR KEGG; hsa:378925; -.
DR MANE-Select; ENST00000434824.2; ENSP00000388207.1; NM_198085.2; NP_932351.1.
DR UCSC; uc003vkk.2; human.
DR CTD; 378925; -.
DR GeneCards; RNF148; -.
DR HGNC; HGNC:22411; RNF148.
DR HPA; ENSG00000235631; Tissue enriched (testis).
DR neXtProt; NX_Q8N7C7; -.
DR OpenTargets; ENSG00000235631; -.
DR PharmGKB; PA134918676; -.
DR VEuPathDB; HostDB:ENSG00000235631; -.
DR eggNOG; KOG4628; Eukaryota.
DR GeneTree; ENSGT00940000163382; -.
DR HOGENOM; CLU_049885_1_2_1; -.
DR InParanoid; Q8N7C7; -.
DR OMA; LAHRTCP; -.
DR OrthoDB; 1487241at2759; -.
DR PhylomeDB; Q8N7C7; -.
DR TreeFam; TF317486; -.
DR PathwayCommons; Q8N7C7; -.
DR BioGRID-ORCS; 378925; 9 hits in 1106 CRISPR screens.
DR GenomeRNAi; 378925; -.
DR Pharos; Q8N7C7; Tdark.
DR PRO; PR:Q8N7C7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N7C7; protein.
DR Bgee; ENSG00000235631; Expressed in sperm and 83 other tissues.
DR ExpressionAtlas; Q8N7C7; baseline and differential.
DR Genevisible; Q8N7C7; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..305
FT /note="RING finger protein 148"
FT /id="PRO_0000255252"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 65..167
FT /note="PA"
FT ZN_FING 258..299
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 221
FT /note="F -> L (in dbSNP:rs7790381)"
FT /id="VAR_028855"
FT CONFLICT 294
FT /note="T -> A (in Ref. 1; BAC05367)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34397 MW; D44B02D1EBDDBE03 CRC64;
MSFLRITPST HSSVSSGLLR LSIFLLLSFP DSNGKAIWTA HLNITFQVGN EITSELGESG
VFGNHSPLER VSGVVALPEG WNQNACHPLT NFSRPKQADS WLALIERGGC TFTHKINVAA
EKGANGVIIY NYQGTGSKVF PMSHQGTENI VAVMISNLKG MEILHSIQKG VYVTVIIEVG
RMHMQWVSHY IMYLFTFLAA TIAYFYLDCV WRLTPRVPNS FTRRRSQIKT DVKKAIDQLQ
LRVLKEGDEE LDLNEDNCVV CFDTYKPQDV VRILTCKHFF HKACIDPWLL AHRTCPMCKC
DILKT
