RN148_MOUSE
ID RN148_MOUSE Reviewed; 316 AA.
AC G3X9R7; Q8CGR1; Q9D3V4;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=RING finger protein 148;
DE AltName: Full=Goliath-related E3 ubiquitin-protein ligase 3;
DE Flags: Precursor;
GN Name=Rnf148; Synonyms=Greul3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RX PubMed=12435366; DOI=10.1006/dbio.2002.0814;
RA Borchers A.G.M., Hufton A.L., Eldridge A.G., Jackson P.K., Harland R.M.,
RA Baker J.C.;
RT "The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus
RT development.";
RL Dev. Biol. 251:395-408(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AY155440; AAN75221.1; -; mRNA.
DR EMBL; AK017027; BAB30557.1; -; mRNA.
DR EMBL; AC155850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466533; EDL13833.1; -; Genomic_DNA.
DR CCDS; CCDS51726.1; -.
DR RefSeq; NP_082030.1; NM_027754.1.
DR AlphaFoldDB; G3X9R7; -.
DR SMR; G3X9R7; -.
DR STRING; 10090.ENSMUSP00000100592; -.
DR GlyGen; G3X9R7; 1 site.
DR PaxDb; G3X9R7; -.
DR PRIDE; G3X9R7; -.
DR ProteomicsDB; 300490; -.
DR Antibodypedia; 31742; 142 antibodies from 19 providers.
DR Ensembl; ENSMUST00000104979; ENSMUSP00000100592; ENSMUSG00000078179.
DR GeneID; 71300; -.
DR KEGG; mmu:71300; -.
DR UCSC; uc009bbl.2; mouse.
DR CTD; 378925; -.
DR MGI; MGI:1918550; Rnf148.
DR VEuPathDB; HostDB:ENSMUSG00000078179; -.
DR eggNOG; KOG4628; Eukaryota.
DR GeneTree; ENSGT00940000163382; -.
DR HOGENOM; CLU_049885_1_0_1; -.
DR InParanoid; G3X9R7; -.
DR OMA; LAHRTCP; -.
DR OrthoDB; 1487241at2759; -.
DR PhylomeDB; G3X9R7; -.
DR TreeFam; TF317486; -.
DR BioGRID-ORCS; 71300; 3 hits in 73 CRISPR screens.
DR PRO; PR:G3X9R7; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; G3X9R7; protein.
DR Bgee; ENSMUSG00000078179; Expressed in spermatid and 3 other tissues.
DR Genevisible; G3X9R7; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT SIGNAL 1..12
FT /evidence="ECO:0000255"
FT CHAIN 13..316
FT /note="RING finger protein 148"
FT /id="PRO_0000415818"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 84..178
FT /note="PA"
FT ZN_FING 269..310
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 42
FT /note="L -> F (in Ref. 1; AAN75221)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="G -> E (in Ref. 2; BAB30557)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 35463 MW; 153154D78A355B91 CRC64;
MLLCVSCLSV NGEMNPLGPT PSVHRSVSFW LLRLSVFLLL SLRDSKGKAI WTAHLNITFQ
VGNRIISELG ESGVFGNHSP LERVSGAVVL PEGWNQNACS PLTNFSRPDQ TDTWLALIER
GGCTFTHKIN LAAEKGANGV IIYNYPGTGN KVFPMSHQGT ENIVAVMIGN LKGMELLHLI
QQGVYVTIII EVGRMHMPWL SHYVMSLFTF LAATVTYLFL YCAWRPRVSN SSTRRQRQLK
ADVKKAIGQL QLRVLQDGDK ELDPNEDSCV VCFDMYKAQD VIRILTCKHF FHKTCIDPWL
LAHRTCPMCK CDILKP
