RN151_HUMAN
ID RN151_HUMAN Reviewed; 245 AA.
AC Q2KHN1; Q8NHS5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=RING finger protein 151;
GN Name=RNF151;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in acrosome formation of spermatids.
CC -!- SUBUNIT: Interacts with DTNBP1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q2KHN1; Q9ULW3: ABT1; NbExp=3; IntAct=EBI-12002474, EBI-2602396;
CC Q2KHN1; Q5HYN5: CT45A1; NbExp=3; IntAct=EBI-12002474, EBI-12051833;
CC Q2KHN1; Q92997: DVL3; NbExp=3; IntAct=EBI-12002474, EBI-739789;
CC Q2KHN1; Q8N9E0: FAM133A; NbExp=3; IntAct=EBI-12002474, EBI-10268158;
CC Q2KHN1; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-12002474, EBI-8468186;
CC Q2KHN1; P61328-2: FGF12; NbExp=3; IntAct=EBI-12002474, EBI-10699759;
CC Q2KHN1; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-12002474, EBI-742459;
CC Q2KHN1; Q6ZUT1: NKAPD1; NbExp=6; IntAct=EBI-12002474, EBI-3920396;
CC Q2KHN1; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-12002474, EBI-14066006;
CC Q2KHN1; O43395: PRPF3; NbExp=3; IntAct=EBI-12002474, EBI-744322;
CC Q2KHN1; Q6ZMJ2-2: SCARA5; NbExp=3; IntAct=EBI-12002474, EBI-12823227;
CC Q2KHN1; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-12002474, EBI-10268630;
CC Q2KHN1; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-12002474, EBI-947459;
CC Q2KHN1; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-12002474, EBI-10180829;
CC Q2KHN1; Q9NQZ6: ZC4H2; NbExp=3; IntAct=EBI-12002474, EBI-747993;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; BC029501; AAH29501.2; -; mRNA.
DR EMBL; BC113014; AAI13015.1; -; mRNA.
DR CCDS; CCDS58405.1; -.
DR RefSeq; NP_001335640.1; NM_001348711.1.
DR RefSeq; NP_777563.2; NM_174903.5.
DR AlphaFoldDB; Q2KHN1; -.
DR SMR; Q2KHN1; -.
DR BioGRID; 126977; 131.
DR IntAct; Q2KHN1; 15.
DR STRING; 9606.ENSP00000456566; -.
DR iPTMnet; Q2KHN1; -.
DR PhosphoSitePlus; Q2KHN1; -.
DR BioMuta; RNF151; -.
DR DMDM; 119371030; -.
DR MassIVE; Q2KHN1; -.
DR PaxDb; Q2KHN1; -.
DR PeptideAtlas; Q2KHN1; -.
DR PRIDE; Q2KHN1; -.
DR Antibodypedia; 23363; 27 antibodies from 14 providers.
DR DNASU; 146310; -.
DR Ensembl; ENST00000569714.6; ENSP00000456566.1; ENSG00000179580.10.
DR GeneID; 146310; -.
DR KEGG; hsa:146310; -.
DR MANE-Select; ENST00000569714.6; ENSP00000456566.1; NM_174903.6; NP_777563.2.
DR UCSC; uc002cnt.1; human.
DR CTD; 146310; -.
DR GeneCards; RNF151; -.
DR HGNC; HGNC:23235; RNF151.
DR HPA; ENSG00000179580; Tissue enriched (testis).
DR neXtProt; NX_Q2KHN1; -.
DR OpenTargets; ENSG00000179580; -.
DR PharmGKB; PA134992556; -.
DR VEuPathDB; HostDB:ENSG00000179580; -.
DR eggNOG; KOG0297; Eukaryota.
DR GeneTree; ENSGT00530000063647; -.
DR InParanoid; Q2KHN1; -.
DR OMA; HNCYKQL; -.
DR OrthoDB; 918518at2759; -.
DR PhylomeDB; Q2KHN1; -.
DR TreeFam; TF351947; -.
DR PathwayCommons; Q2KHN1; -.
DR SignaLink; Q2KHN1; -.
DR BioGRID-ORCS; 146310; 13 hits in 1106 CRISPR screens.
DR GenomeRNAi; 146310; -.
DR Pharos; Q2KHN1; Tdark.
DR PRO; PR:Q2KHN1; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q2KHN1; protein.
DR Bgee; ENSG00000179580; Expressed in left testis and 90 other tissues.
DR ExpressionAtlas; Q2KHN1; baseline and differential.
DR Genevisible; Q2KHN1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR013010; Znf_SIAH.
DR InterPro; IPR001293; Znf_TRAF.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51081; ZF_SIAH; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Differentiation; Metal-binding; Nucleus; Reference proteome;
KW Spermatogenesis; Zinc; Zinc-finger.
FT CHAIN 1..245
FT /note="RING finger protein 151"
FT /id="PRO_0000255254"
FT ZN_FING 20..58
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 101..156
FT /note="TRAF-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 219..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 27412 MW; D96AF6A1B7DDD755 CRC64;
MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR QKTCPCCRKE
VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK GHQDSCPFEL TACPNEGCTS
QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL DPAERARHNC YRELHNAWSV RQERRRPLLL
SLLRRVRWLD QATSVVRREL AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA
NIPCK
