RN175_HUMAN
ID RN175_HUMAN Reviewed; 328 AA.
AC Q8N4F7; C9JL66; Q8NB61;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=RING finger protein 175;
GN Name=RNF175;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-322.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N4F7; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10265447, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4F7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4F7-2; Sequence=VSP_055433, VSP_055434, VSP_055435,
CC VSP_055436;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK091509; BAC03680.1; -; mRNA.
DR EMBL; AC020703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC106865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471056; EAX04951.1; -; Genomic_DNA.
DR EMBL; BC034385; AAH34385.1; -; mRNA.
DR CCDS; CCDS47149.1; -. [Q8N4F7-1]
DR RefSeq; NP_775933.1; NM_173662.2. [Q8N4F7-1]
DR AlphaFoldDB; Q8N4F7; -.
DR BioGRID; 130136; 5.
DR IntAct; Q8N4F7; 1.
DR STRING; 9606.ENSP00000340979; -.
DR GlyGen; Q8N4F7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N4F7; -.
DR PhosphoSitePlus; Q8N4F7; -.
DR BioMuta; RNF175; -.
DR DMDM; 296452878; -.
DR EPD; Q8N4F7; -.
DR jPOST; Q8N4F7; -.
DR MassIVE; Q8N4F7; -.
DR MaxQB; Q8N4F7; -.
DR PaxDb; Q8N4F7; -.
DR PeptideAtlas; Q8N4F7; -.
DR PRIDE; Q8N4F7; -.
DR Antibodypedia; 27903; 82 antibodies from 17 providers.
DR DNASU; 285533; -.
DR Ensembl; ENST00000347063.9; ENSP00000340979.4; ENSG00000145428.15. [Q8N4F7-1]
DR GeneID; 285533; -.
DR KEGG; hsa:285533; -.
DR MANE-Select; ENST00000347063.9; ENSP00000340979.4; NM_173662.4; NP_775933.2.
DR UCSC; uc003int.4; human. [Q8N4F7-1]
DR CTD; 285533; -.
DR DisGeNET; 285533; -.
DR GeneCards; RNF175; -.
DR HGNC; HGNC:27735; RNF175.
DR HPA; ENSG00000145428; Tissue enhanced (brain, choroid plexus).
DR neXtProt; NX_Q8N4F7; -.
DR OpenTargets; ENSG00000145428; -.
DR PharmGKB; PA134909663; -.
DR VEuPathDB; HostDB:ENSG00000145428; -.
DR eggNOG; KOG1734; Eukaryota.
DR GeneTree; ENSGT00390000013075; -.
DR HOGENOM; CLU_055016_1_0_1; -.
DR InParanoid; Q8N4F7; -.
DR OMA; AIVFTMC; -.
DR OrthoDB; 1167893at2759; -.
DR PhylomeDB; Q8N4F7; -.
DR TreeFam; TF314357; -.
DR PathwayCommons; Q8N4F7; -.
DR SignaLink; Q8N4F7; -.
DR BioGRID-ORCS; 285533; 10 hits in 1108 CRISPR screens.
DR ChiTaRS; RNF175; human.
DR GenomeRNAi; 285533; -.
DR Pharos; Q8N4F7; Tdark.
DR PRO; PR:Q8N4F7; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N4F7; protein.
DR Bgee; ENSG00000145428; Expressed in middle temporal gyrus and 136 other tissues.
DR ExpressionAtlas; Q8N4F7; baseline and differential.
DR Genevisible; Q8N4F7; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR040176; RNF121/RNF175.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13407; PTHR13407; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Metal-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..328
FT /note="RING finger protein 175"
FT /id="PRO_0000245599"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 227..277
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT VAR_SEQ 1..6
FT /note="MAAGTA -> MADPTI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055433"
FT VAR_SEQ 7..134
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055434"
FT VAR_SEQ 256..309
FT /note="FHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQILDWLRYL
FT VA -> YPFQRKLFGLHQASFFPPSPPPPPVPISSILLTFHAQTPVLYPPAQSSLPVCP
FT C (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055435"
FT VAR_SEQ 310..328
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055436"
FT VARIANT 159
FT /note="M -> V (in dbSNP:rs10517577)"
FT /id="VAR_026998"
FT VARIANT 307
FT /note="L -> F (in dbSNP:rs1337)"
FT /id="VAR_026999"
FT VARIANT 315
FT /note="I -> M (in dbSNP:rs1339)"
FT /id="VAR_027000"
FT VARIANT 322
FT /note="I -> N (in dbSNP:rs2405432)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027001"
SQ SEQUENCE 328 AA; 38266 MW; A9EAAE7B4A75B524 CRC64;
MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL
CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL
FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG
IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE
EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI
LDWLRYLVAW QPVVIGIVQG IIYSLGLE
