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RN185_CHICK
ID   RN185_CHICK             Reviewed;         194 AA.
AC   Q5ZIR9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=E3 ubiquitin-protein ligase RNF185;
DE            EC=2.3.2.27 {ECO:0000250|UniProtKB:Q96GF1};
DE   AltName: Full=RING finger protein 185;
GN   Name=RNF185; ORFNames=RCJMB04_23p11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: E3 ubiquitin-protein ligase that regulates selective
CC       mitochondrial autophagy by mediating 'Lys-63'-linked
CC       polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated
CC       degradation (ERAD) pathway, which targets misfolded proteins that
CC       accumulate in the endoplasmic reticulum (ER) for ubiquitination and
CC       subsequent proteasome-mediated degradation. Protects cells from ER
CC       stress-induced apoptosis. Responsible for the cotranslational
CC       ubiquitination and degradation of CFTR in the ERAD pathway. Also acts
CC       as a regulator of the innate antiviral response by catalyzing 'Lys-27'-
CC       linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-
CC       AMP synthase activity. Preferentially associates with the E2 enzymes
CC       UBE2J1 and UBE2J2 (By similarity). {ECO:0000250|UniProtKB:Q96GF1}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q96GF1};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q96GF1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q96GF1}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q96GF1}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q96GF1}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q96GF1}.
CC   -!- DOMAIN: The RING-type zinc finger domain is responsible for E3
CC       ubiquitin ligase activity. {ECO:0000250|UniProtKB:Q96GF1}.
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DR   EMBL; AJ720715; CAG32374.1; -; mRNA.
DR   RefSeq; NP_001007841.1; NM_001007840.1.
DR   RefSeq; XP_015130814.1; XM_015275328.1.
DR   RefSeq; XP_015130815.1; XM_015275329.1.
DR   AlphaFoldDB; Q5ZIR9; -.
DR   SMR; Q5ZIR9; -.
DR   STRING; 9031.ENSGALP00000011262; -.
DR   PaxDb; Q5ZIR9; -.
DR   Ensembl; ENSGALT00000011276; ENSGALP00000011262; ENSGALG00000006960.
DR   GeneID; 416965; -.
DR   KEGG; gga:416965; -.
DR   CTD; 6048; -.
DR   VEuPathDB; HostDB:geneid_416965; -.
DR   eggNOG; KOG0823; Eukaryota.
DR   GeneTree; ENSGT00390000014107; -.
DR   HOGENOM; CLU_055198_2_2_1; -.
DR   InParanoid; Q5ZIR9; -.
DR   OrthoDB; 1510545at2759; -.
DR   PhylomeDB; Q5ZIR9; -.
DR   TreeFam; TF317334; -.
DR   Reactome; R-GGA-382556; ABC-family proteins mediated transport.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5ZIR9; -.
DR   Proteomes; UP000000539; Chromosome 15.
DR   Bgee; ENSGALG00000006960; Expressed in testis and 13 other tissues.
DR   ExpressionAtlas; Q5ZIR9; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; ISS:UniProtKB.
DR   GO; GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0044314; P:protein K27-linked ubiquitination; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR045103; RNF5/RNF185-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12313; PTHR12313; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Immunity; Innate immunity; Membrane;
KW   Metal-binding; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix;
KW   Ubl conjugation pathway; Zinc; Zinc-finger.
FT   CHAIN           1..194
FT                   /note="E3 ubiquitin-protein ligase RNF185"
FT                   /id="PRO_0000247524"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         41..82
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          31..82
FT                   /note="Required for ubiquitin ligase activity and
FT                   protection against ER stress-induced cell death"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GF1"
FT   REGION          92..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  20828 MW;  1162DE994BC8D635 CRC64;
     MASKGPTTSA STKSSSTGGT SGSSSSNGAG DNTNQDNTFE CNICLDTAKD AVISLCGHLF
     CWPCLHQWLE TRPNRQVCPV CKAGISRDKV IPLYGRGSTG QQDPREKTPP RPQGQRPEPE
     NRGGFQGFGF GDGGFQMSFG IGAFPFGIFA TAFNINDGRP PPAVPGTPQY VDEQFLSRLF
     LFVALVIMFW LLIA
 
 
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