ID   AB17C_XENTR             Reviewed;         310 AA.
AC   Q6GL10;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Alpha/beta hydrolase domain-containing protein 17C {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 17C {ECO:0000250|UniProtKB:Q6PCB6};
DE            EC=3.1.2.22 {ECO:0000250|UniProtKB:Q8VCV1};
GN   Name=abhd17c {ECO:0000250|UniProtKB:Q6PCB6};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in
CC       proteins. {ECO:0000250|UniProtKB:Q6PCB6}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC         hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC         Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:74151; EC=3.1.2.22;
CC         Evidence={ECO:0000250|UniProtKB:Q6PCB6};
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane
CC       {ECO:0000250|UniProtKB:B5DFK7}; Lipid-anchor
CC       {ECO:0000250|UniProtKB:B5DFK7}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:B5DFK7}. Cell projection, dendritic spine
CC       {ECO:0000250|UniProtKB:B5DFK7}. Postsynaptic density membrane
CC       {ECO:0000250|UniProtKB:B5DFK7}.
CC   -!- PTM: Palmitoylated on cysteine residues located in a cysteine cluster
CC       at the N-terminus which promotes membrane localization.
CC       {ECO:0000250|UniProtKB:Q7M759}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD17 family.
CC       {ECO:0000305}.
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DR   EMBL; BC074709; AAH74709.1; -; mRNA.
DR   RefSeq; NP_001004867.1; NM_001004867.1.
DR   AlphaFoldDB; Q6GL10; -.
DR   SMR; Q6GL10; -.
DR   STRING; 8364.ENSXETP00000049402; -.
DR   ESTHER; xentr-q6gl10; ABHD17-depalmitoylase.
DR   MEROPS; S09.053; -.
DR   PaxDb; Q6GL10; -.
DR   DNASU; 448170; -.
DR   GeneID; 448170; -.
DR   KEGG; xtr:448170; -.
DR   CTD; 58489; -.
DR   Xenbase; XB-GENE-6040893; abhd17c.
DR   eggNOG; KOG1552; Eukaryota.
DR   InParanoid; Q6GL10; -.
DR   OMA; FNERAEW; -.
DR   OrthoDB; 629316at2759; -.
DR   PhylomeDB; Q6GL10; -.
DR   TreeFam; TF314365; -.
DR   Reactome; R-XTR-9648002; RAS processing.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027627; Expressed in 2-cell stage embryo and 13 other tissues.
DR   ExpressionAtlas; Q6GL10; differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR   GO; GO:0002084; P:protein depalmitoylation; IBA:GO_Central.
DR   GO; GO:0099175; P:regulation of postsynapse organization; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022742; Hydrolase_4.
DR   Pfam; PF12146; Hydrolase_4; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Endosome; Hydrolase; Lipoprotein; Membrane;
KW   Palmitate; Postsynaptic cell membrane; Reference proteome; Synapse.
FT   CHAIN           1..310
FT                   /note="Alpha/beta hydrolase domain-containing protein 17C"
FT                   /id="PRO_0000297518"
FT   ACT_SITE        192
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GS6"
FT   ACT_SITE        257
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:O75608"
FT   ACT_SITE        286
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:O75608"
SQ   SEQUENCE   310 AA;  34531 MW;  27A13D9E1E8F1C3A CRC64;
     MPEQGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVREMEAP AGTAQPPREE
     GSGEPAACSL HLSERADWQY SQRELDAVEV FRWRTERGSC LGCMFVRCSP GSRYTVLFSH
     GNAVDLGQMC SFYIGLGTRI NCNIFSYDYS GYGVSSGKPS EKNLYADIEA AWHALRTRYG
     VTPENIILYG QSIGTVPTVD LASRYECAAV ILHSPLMSGL RVAFPDTRKT YCFDAFPSID
     KISKVTSPVL IIHGTEDEVI DFSHGLAMYE RCPRAVEPLW VEGAGHNDIE LYAQYLERLK
     QFISHELPNS