RN208_HUMAN
ID RN208_HUMAN Reviewed; 261 AA.
AC Q9H0X6; A2BFA0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=RING finger protein 208;
GN Name=RNF208;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-261.
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 71-261.
RC TISSUE=Fetal brain;
RA Kang L., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.;
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-261.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- INTERACTION:
CC Q9H0X6; P07550: ADRB2; NbExp=3; IntAct=EBI-751555, EBI-491169;
CC Q9H0X6; Q86V38: ATN1; NbExp=3; IntAct=EBI-751555, EBI-11954292;
CC Q9H0X6; P28329-3: CHAT; NbExp=3; IntAct=EBI-751555, EBI-25837549;
CC Q9H0X6; Q02930-3: CREB5; NbExp=3; IntAct=EBI-751555, EBI-10192698;
CC Q9H0X6; Q15038: DAZAP2; NbExp=10; IntAct=EBI-751555, EBI-724310;
CC Q9H0X6; P22607: FGFR3; NbExp=3; IntAct=EBI-751555, EBI-348399;
CC Q9H0X6; P62993: GRB2; NbExp=3; IntAct=EBI-751555, EBI-401755;
CC Q9H0X6; Q14957: GRIN2C; NbExp=3; IntAct=EBI-751555, EBI-8285963;
CC Q9H0X6; P28799: GRN; NbExp=3; IntAct=EBI-751555, EBI-747754;
CC Q9H0X6; P49639: HOXA1; NbExp=3; IntAct=EBI-751555, EBI-740785;
CC Q9H0X6; O60333-2: KIF1B; NbExp=3; IntAct=EBI-751555, EBI-10975473;
CC Q9H0X6; Q92876: KLK6; NbExp=3; IntAct=EBI-751555, EBI-2432309;
CC Q9H0X6; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-751555, EBI-11992140;
CC Q9H0X6; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-751555, EBI-3957672;
CC Q9H0X6; Q99732: LITAF; NbExp=3; IntAct=EBI-751555, EBI-725647;
CC Q9H0X6; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-751555, EBI-12813389;
CC Q9H0X6; Q13526: PIN1; NbExp=3; IntAct=EBI-751555, EBI-714158;
CC Q9H0X6; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-751555, EBI-396669;
CC Q9H0X6; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-751555, EBI-2341200;
CC Q9H0X6; P49247: RPIA; NbExp=3; IntAct=EBI-751555, EBI-744831;
CC Q9H0X6; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-751555, EBI-5235340;
CC Q9H0X6; Q99469: STAC; NbExp=3; IntAct=EBI-751555, EBI-2652799;
CC Q9H0X6; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-751555, EBI-741480;
CC Q9H0X6; Q9UHD9: UBQLN2; NbExp=6; IntAct=EBI-751555, EBI-947187;
CC Q9H0X6; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-751555, EBI-11975223;
CC Q9H0X6; O76024: WFS1; NbExp=3; IntAct=EBI-751555, EBI-720609;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16958.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH16958.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=AAL16809.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAB66475.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX255925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136540; CAB66475.1; ALT_INIT; mRNA.
DR EMBL; AF416715; AAL16809.1; ALT_INIT; mRNA.
DR EMBL; BC016958; AAH16958.1; ALT_SEQ; mRNA.
DR CCDS; CCDS7037.2; -.
DR RefSeq; NP_112587.2; NM_031297.4.
DR AlphaFoldDB; Q9H0X6; -.
DR BioGRID; 608244; 74.
DR IntAct; Q9H0X6; 28.
DR MINT; Q9H0X6; -.
DR STRING; 9606.ENSP00000376572; -.
DR iPTMnet; Q9H0X6; -.
DR PhosphoSitePlus; Q9H0X6; -.
DR BioMuta; RNF208; -.
DR DMDM; 239938696; -.
DR jPOST; Q9H0X6; -.
DR MassIVE; Q9H0X6; -.
DR PaxDb; Q9H0X6; -.
DR PeptideAtlas; Q9H0X6; -.
DR PRIDE; Q9H0X6; -.
DR ProteomicsDB; 80341; -.
DR Antibodypedia; 32414; 81 antibodies from 16 providers.
DR DNASU; 727800; -.
DR Ensembl; ENST00000391553.3; ENSP00000375397.1; ENSG00000212864.4.
DR Ensembl; ENST00000392827.2; ENSP00000376572.1; ENSG00000212864.4.
DR GeneID; 727800; -.
DR KEGG; hsa:727800; -.
DR MANE-Select; ENST00000391553.3; ENSP00000375397.1; NM_031297.7; NP_112587.2.
DR UCSC; uc004clz.2; human.
DR CTD; 727800; -.
DR GeneCards; RNF208; -.
DR HGNC; HGNC:25420; RNF208.
DR HPA; ENSG00000212864; Tissue enhanced (brain).
DR MIM; 618993; gene.
DR neXtProt; NX_Q9H0X6; -.
DR OpenTargets; ENSG00000212864; -.
DR PharmGKB; PA162401649; -.
DR VEuPathDB; HostDB:ENSG00000212864; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00680000100126; -.
DR HOGENOM; CLU_061185_0_0_1; -.
DR InParanoid; Q9H0X6; -.
DR OMA; EVCFHRQ; -.
DR OrthoDB; 489543at2759; -.
DR PhylomeDB; Q9H0X6; -.
DR TreeFam; TF331869; -.
DR PathwayCommons; Q9H0X6; -.
DR SignaLink; Q9H0X6; -.
DR BioGRID-ORCS; 727800; 8 hits in 1113 CRISPR screens.
DR ChiTaRS; RNF208; human.
DR GenomeRNAi; 727800; -.
DR Pharos; Q9H0X6; Tbio.
DR PRO; PR:Q9H0X6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9H0X6; protein.
DR Bgee; ENSG00000212864; Expressed in right frontal lobe and 98 other tissues.
DR Genevisible; Q9H0X6; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:FlyBase.
DR GO; GO:0051865; P:protein autoubiquitination; IDA:FlyBase.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd16559; RING-HC_RNF208; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR040101; RNF208.
DR InterPro; IPR040100; RNF208_RING-HC.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22791:SF3; PTHR22791:SF3; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..261
FT /note="RING finger protein 208"
FT /id="PRO_0000274613"
FT ZN_FING 143..190
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 83..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 102
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
SQ SEQUENCE 261 AA; 27964 MW; 5289AF5931E872E5 CRC64;
MPSDPGPEAG SGWPGLLMSC LKGPHVILKM EAMKIVHPEK FPELPAAPCF PPAPRPTPTL
APKRAWPSDT EIIVNQACGG DMPALEGAPH TPPLPRRPRK GSSELGFPRV APEDEVIVNQ
YVIRPGPSAS AASSAAAGEP LECPTCGHSY NVTQRRPRVL SCLHSVCEQC LQILYESCPK
YKFISCPTCR RETVLFTDYG LAALAVNTSI LSRLPPEALT APSGGQWGAE PEGSCYQTFR
QYCGAACTCH VRNPLSACSI M
