RN215_HUMAN
ID RN215_HUMAN Reviewed; 377 AA.
AC Q9Y6U7; A6NEL1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=RING finger protein 215;
GN Name=RNF215;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD43187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC004997; AAD43187.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS33633.1; -.
DR RefSeq; NP_001017981.1; NM_001017981.1.
DR AlphaFoldDB; Q9Y6U7; -.
DR SMR; Q9Y6U7; -.
DR BioGRID; 128317; 6.
DR IntAct; Q9Y6U7; 1.
DR STRING; 9606.ENSP00000371800; -.
DR GlyGen; Q9Y6U7; 1 site.
DR iPTMnet; Q9Y6U7; -.
DR PhosphoSitePlus; Q9Y6U7; -.
DR BioMuta; RNF215; -.
DR DMDM; 147732500; -.
DR MassIVE; Q9Y6U7; -.
DR PaxDb; Q9Y6U7; -.
DR PeptideAtlas; Q9Y6U7; -.
DR PRIDE; Q9Y6U7; -.
DR ProteomicsDB; 86792; -.
DR Antibodypedia; 24705; 108 antibodies from 15 providers.
DR DNASU; 200312; -.
DR Ensembl; ENST00000382363.8; ENSP00000371800.3; ENSG00000099999.15.
DR GeneID; 200312; -.
DR KEGG; hsa:200312; -.
DR MANE-Select; ENST00000382363.8; ENSP00000371800.3; NM_001017981.2; NP_001017981.1.
DR UCSC; uc003ahp.4; human.
DR CTD; 200312; -.
DR GeneCards; RNF215; -.
DR HGNC; HGNC:33434; RNF215.
DR HPA; ENSG00000099999; Low tissue specificity.
DR neXtProt; NX_Q9Y6U7; -.
DR PharmGKB; PA162401807; -.
DR VEuPathDB; HostDB:ENSG00000099999; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000159671; -.
DR HOGENOM; CLU_049329_0_0_1; -.
DR InParanoid; Q9Y6U7; -.
DR OMA; GAQAYPK; -.
DR OrthoDB; 1487241at2759; -.
DR PhylomeDB; Q9Y6U7; -.
DR TreeFam; TF317074; -.
DR PathwayCommons; Q9Y6U7; -.
DR SignaLink; Q9Y6U7; -.
DR BioGRID-ORCS; 200312; 9 hits in 1117 CRISPR screens.
DR GenomeRNAi; 200312; -.
DR Pharos; Q9Y6U7; Tdark.
DR PRO; PR:Q9Y6U7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9Y6U7; protein.
DR Bgee; ENSG00000099999; Expressed in right hemisphere of cerebellum and 105 other tissues.
DR ExpressionAtlas; Q9Y6U7; baseline and differential.
DR Genevisible; Q9Y6U7; HS.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..377
FT /note="RING finger protein 215"
FT /id="PRO_0000287534"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT ZN_FING 325..366
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 322
FT /note="A -> T (in dbSNP:rs5749088)"
FT /id="VAR_032319"
SQ SEQUENCE 377 AA; 41101 MW; 796870D29813AFB3 CRC64;
MGPAARPALR SPPPPPPPPP SPLLLLLPLL PLWLGLAGPG AAADGSEPAA GAGRGGARAV
RVDVRLPRQD ALVLEGVRIG SEADPAPLLG GRLLLMDIVD AEQEAPVEGW IAVAYVGKEQ
AAQFHQENKG SGPQAYPKAL VQQMRRALFL GASALLLLIL NHNVVRELDI SQLLLRPVIV
LHYSSNVTKL LDALLQRTQA TAEITSGESL SANIEWKLTL WTTCGLSKDG YGGWQDLVCL
GGSRAQEQKP LQQLWNAILL VAMLLCTGLV VQAQRQASRQ SQRELGGQVD LFKRRVVRRL
ASLKTRRCRL SRAAQGLPDP GAETCAVCLD YFCNKQWLRV LPCKHEFHRD CVDPWLMLQQ
TCPLCKFNVL GNRYSDD
