RN215_MOUSE
ID RN215_MOUSE Reviewed; 379 AA.
AC Q5SPX3; Q5SPX2; Q5SPX4; Q9DCW1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=RING finger protein 215;
GN Name=Rnf215;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI25741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI25743.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK002414; BAB22082.1; -; mRNA.
DR EMBL; AL807825; CAI25741.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL807825; CAI25742.1; -; Genomic_DNA.
DR EMBL; AL807825; CAI25743.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC103627; AAI03628.1; -; mRNA.
DR EMBL; BC115907; AAI15908.1; -; mRNA.
DR EMBL; BC115908; AAI15909.1; -; mRNA.
DR CCDS; CCDS24378.1; -.
DR RefSeq; NP_082135.2; NM_027859.2.
DR AlphaFoldDB; Q5SPX3; -.
DR SMR; Q5SPX3; -.
DR STRING; 10090.ENSMUSP00000003677; -.
DR GlyGen; Q5SPX3; 1 site.
DR PhosphoSitePlus; Q5SPX3; -.
DR PaxDb; Q5SPX3; -.
DR PRIDE; Q5SPX3; -.
DR Antibodypedia; 24705; 108 antibodies from 15 providers.
DR DNASU; 71673; -.
DR Ensembl; ENSMUST00000003677; ENSMUSP00000003677; ENSMUSG00000003581.
DR GeneID; 71673; -.
DR KEGG; mmu:71673; -.
DR UCSC; uc007hui.1; mouse.
DR CTD; 200312; -.
DR MGI; MGI:1918923; Rnf215.
DR VEuPathDB; HostDB:ENSMUSG00000003581; -.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000159671; -.
DR HOGENOM; CLU_049329_0_0_1; -.
DR InParanoid; Q5SPX3; -.
DR OMA; GAQAYPK; -.
DR OrthoDB; 1487241at2759; -.
DR PhylomeDB; Q5SPX3; -.
DR TreeFam; TF317074; -.
DR BioGRID-ORCS; 71673; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q5SPX3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SPX3; protein.
DR Bgee; ENSMUSG00000003581; Expressed in hypothalamus and 61 other tissues.
DR ExpressionAtlas; Q5SPX3; baseline and differential.
DR Genevisible; Q5SPX3; MM.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..379
FT /note="RING finger protein 215"
FT /id="PRO_0000287535"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT ZN_FING 327..368
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 60..61
FT /note="RS -> PL (in Ref. 1; BAB22082)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 379 AA; 41610 MW; 6C34B8E05C3E067D CRC64;
MGSADRPALR SPSLPPPPPS PPSPLLLLLP LLPLWLGLMG PGAAADGSEP ATGEGRGGAR
SVRVDVKLPR QDALVLEGVR IGPEDGPEPL LGGRLLLMDV VDAEQEIPVD GWIAVAYVGK
EQVAQFHQEN QGSSQKAYPK ALVQQMRRAL FLGASALLLL ILNHSVVREL DVSQLLLRPV
IVLHYSSNVT KLLEALLQRT QATAEISSGE SLSANIEWKL TLWTTCGLSK DGYGGWQDLV
CLGGAQAQEQ KPLQQLWNAI LLVAMLLCTG LVVQAQRQAS RQNQQEPGGQ EDLFKRRVVR
RLASLKTRRC RLSRAAHSLP EPGTETCAVC LDYFCNKQWL RVLPCKHEFH RDCVDPWLML
QQTCPLCKFN VLGNHYSDD
