ID   RN222_MOUSE             Reviewed;         211 AA.
AC   Q8CEF8; B1ARA2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=RING finger protein 222;
GN   Name=Rnf222;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AK028294; BAC25864.1; -; mRNA.
DR   EMBL; AL603662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS24871.1; -.
DR   RefSeq; NP_796034.2; NM_177060.3.
DR   RefSeq; XP_006533603.1; XM_006533540.2.
DR   RefSeq; XP_006533605.1; XM_006533542.3.
DR   RefSeq; XP_006533606.1; XM_006533543.2.
DR   RefSeq; XP_017170097.1; XM_017314608.1.
DR   AlphaFoldDB; Q8CEF8; -.
DR   BioGRID; 235719; 1.
DR   STRING; 10090.ENSMUSP00000067364; -.
DR   PhosphoSitePlus; Q8CEF8; -.
DR   PaxDb; Q8CEF8; -.
DR   PRIDE; Q8CEF8; -.
DR   ProteomicsDB; 300425; -.
DR   Antibodypedia; 62437; 5 antibodies from 5 providers.
DR   DNASU; 320040; -.
DR   Ensembl; ENSMUST00000065213; ENSMUSP00000067364; ENSMUSG00000046490.
DR   GeneID; 320040; -.
DR   KEGG; mmu:320040; -.
DR   UCSC; uc007jog.1; mouse.
DR   CTD; 643904; -.
DR   MGI; MGI:2443227; Rnf222.
DR   VEuPathDB; HostDB:ENSMUSG00000046490; -.
DR   eggNOG; ENOG502S4BM; Eukaryota.
DR   GeneTree; ENSGT00390000002856; -.
DR   HOGENOM; CLU_1242627_0_0_1; -.
DR   InParanoid; Q8CEF8; -.
DR   OMA; TRSFCCR; -.
DR   OrthoDB; 1313828at2759; -.
DR   PhylomeDB; Q8CEF8; -.
DR   TreeFam; TF333220; -.
DR   BioGRID-ORCS; 320040; 3 hits in 72 CRISPR screens.
DR   ChiTaRS; Rnf222; mouse.
DR   PRO; PR:Q8CEF8; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8CEF8; protein.
DR   Bgee; ENSMUSG00000046490; Expressed in lip and 14 other tissues.
DR   Genevisible; Q8CEF8; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR042973; RNF222.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR47095; PTHR47095; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..211
FT                   /note="RING finger protein 222"
FT                   /id="PRO_0000329086"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         14..65
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   CONFLICT        16
FT                   /note="V -> M (in Ref. 1; BAC25864)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   211 AA;  23003 MW;  D1F6B87AB8E84C50 CRC64;
     MSEGGSKDSS GSECPVCYEK FRDLDGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTIV
     CPICRYVTFL SKKSSRWPSM LDKSSQTLTV PVGLPSTPSP DRGGHTNPLV ISHQVWRQSS
     SQGSQVPLDL LPSLPRESQI FIISRHGMPL GEQDSVLPRR SLAEISEASP APSATRSFCC
     RSRALLLITL IAVVAVVAAI LPWVLLVRKQ A