RN223_HUMAN
ID RN223_HUMAN Reviewed; 249 AA.
AC E7ERA6; B4DKI4;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=RING finger protein 223;
GN Name=RNF223;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK296576; BAG59196.1; -; mRNA.
DR EMBL; AL390719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53257.1; -.
DR RefSeq; NP_001192181.1; NM_001205252.1.
DR AlphaFoldDB; E7ERA6; -.
DR IntAct; E7ERA6; 1.
DR STRING; 9606.ENSP00000410533; -.
DR iPTMnet; E7ERA6; -.
DR PhosphoSitePlus; E7ERA6; -.
DR BioMuta; RNF223; -.
DR jPOST; E7ERA6; -.
DR MassIVE; E7ERA6; -.
DR MaxQB; E7ERA6; -.
DR PaxDb; E7ERA6; -.
DR PeptideAtlas; E7ERA6; -.
DR PRIDE; E7ERA6; -.
DR ProteomicsDB; 17748; -.
DR Antibodypedia; 68913; 52 antibodies from 10 providers.
DR DNASU; 401934; -.
DR Ensembl; ENST00000453464.3; ENSP00000410533.1; ENSG00000237330.3.
DR GeneID; 401934; -.
DR KEGG; hsa:401934; -.
DR MANE-Select; ENST00000453464.3; ENSP00000410533.1; NM_001205252.2; NP_001192181.1.
DR UCSC; uc021oen.2; human.
DR CTD; 401934; -.
DR GeneCards; RNF223; -.
DR HGNC; HGNC:40020; RNF223.
DR HPA; ENSG00000237330; Tissue enhanced (esophagus, vagina).
DR neXtProt; NX_E7ERA6; -.
DR OpenTargets; ENSG00000237330; -.
DR VEuPathDB; HostDB:ENSG00000237330; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163259; -.
DR HOGENOM; CLU_094432_0_0_1; -.
DR InParanoid; E7ERA6; -.
DR OMA; WHTAVPP; -.
DR OrthoDB; 1337075at2759; -.
DR PhylomeDB; E7ERA6; -.
DR TreeFam; TF337102; -.
DR PathwayCommons; E7ERA6; -.
DR BioGRID-ORCS; 401934; 17 hits in 1107 CRISPR screens.
DR GenomeRNAi; 401934; -.
DR Pharos; E7ERA6; Tdark.
DR PRO; PR:E7ERA6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; E7ERA6; protein.
DR Bgee; ENSG00000237330; Expressed in lower esophagus mucosa and 41 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..249
FT /note="RING finger protein 223"
FT /id="PRO_0000410919"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 51..102
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 242
FT /note="P -> H (in Ref. 1; BAG59196)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 26629 MW; 0AAD58B080694473 CRC64;
MSSGQQVWHT AVPPPRRSSS IASMPRSPSS AGSPRSPGTP GSERVASPLE CSICFSGYDN
IFKTPKELSC THVFCLECLA RLAAAQPVGR PGGEAVPCPF CRQPTAVPPA GAPALCTSRQ
LQARMPAHLR REEPVWLEGT KLCCQPLPTT PGREPGFVCV DVGLSKPAEP PAPARDPAPR
RGRLARCWAR CRDWRRMALV SALLLMLFCV ALWPVQCALK TGNLRCLPLP PRPPATSTAA
SPLGPLTDN
