ID   RN224_HUMAN             Reviewed;         156 AA.
AC   P0DH78;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=RING finger protein 224;
GN   Name=RNF224;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
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DR   EMBL; BX255925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS55356.1; -.
DR   RefSeq; NP_001177157.1; NM_001190228.1.
DR   RefSeq; XP_011517216.1; XM_011518914.2.
DR   AlphaFoldDB; P0DH78; -.
DR   SMR; P0DH78; -.
DR   BioGRID; 568894; 1.
DR   BioMuta; RNF224; -.
DR   DMDM; 342179218; -.
DR   PaxDb; P0DH78; -.
DR   PeptideAtlas; P0DH78; -.
DR   PRIDE; P0DH78; -.
DR   Antibodypedia; 69700; 51 antibodies from 11 providers.
DR   DNASU; 643596; -.
DR   Ensembl; ENST00000445101.4; ENSP00000406665.3; ENSG00000233198.4.
DR   GeneID; 643596; -.
DR   KEGG; hsa:643596; -.
DR   MANE-Select; ENST00000445101.4; ENSP00000406665.3; NM_001190228.2; NP_001177157.1.
DR   UCSC; uc022bqe.2; human.
DR   CTD; 643596; -.
DR   GeneCards; RNF224; -.
DR   HGNC; HGNC:41912; RNF224.
DR   HPA; ENSG00000233198; Tissue enhanced (esophagus, pituitary gland).
DR   neXtProt; NX_P0DH78; -.
DR   OpenTargets; ENSG00000233198; -.
DR   VEuPathDB; HostDB:ENSG00000233198; -.
DR   eggNOG; ENOG502S2Y1; Eukaryota.
DR   GeneTree; ENSGT00510000050587; -.
DR   HOGENOM; CLU_132997_0_0_1; -.
DR   InParanoid; P0DH78; -.
DR   OMA; ANEQRWI; -.
DR   OrthoDB; 1337075at2759; -.
DR   PhylomeDB; P0DH78; -.
DR   TreeFam; TF331690; -.
DR   PathwayCommons; P0DH78; -.
DR   BioGRID-ORCS; 643596; 13 hits in 1052 CRISPR screens.
DR   GenomeRNAi; 643596; -.
DR   Pharos; P0DH78; Tdark.
DR   PRO; PR:P0DH78; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P0DH78; protein.
DR   Bgee; ENSG00000233198; Expressed in right uterine tube and 84 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..156
FT                   /note="RING finger protein 224"
FT                   /id="PRO_0000412182"
FT   ZN_FING         24..71
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   156 AA;  16549 MW;  82B7A9453211E941 CRC64;
     MQDAAAGGPP GLGGGGPPEE RTDCIICCSA YDLSGHLPRR LYCGHTFCQA CVRRLDTPAP
     EQRWIPCPQC RQSTPTPRGG VAMLDLDLAA FLAVKAEREP ARLEPLPLTS LKGSAITRQP
     AGLCPALGPQ PHFPQPRYCC WGCGSLCCPP LGSPEV